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- Antigen structure
- References [16]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 18120-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18120-1-AP, RRID:AB_2250726
- Product name
- MSH6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MSH6 antibody (Cat. #18120-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability.
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer.
RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability.
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane.
TDP43 Interacts with MLH1 and MSH6 Proteins in A DNA Damage-Inducible Manner.
MRE11A: a novel negative regulator of human DNA mismatch repair.
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner.
EZH2 elicits CD8(+) T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.
The MSH2 c.793-1G>A variant disrupts normal splicing and is associated with Lynch syndrome.
Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.
Resolution of sequence divergence for repeat-mediated deletions shows a polarity that is mediated by MLH1.
Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer.
PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors.
Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma.
Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML
Nucleic acids research 2025 Sep 23;53(18)
Nucleic acids research 2025 Sep 23;53(18)
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer.
Duan J, Chen T, Li Q, Zhang Y, Lu T, Xue J, Sun Y, Gao L, Zhang Y
Journal for immunotherapy of cancer 2025 Mar 13;13(3)
Journal for immunotherapy of cancer 2025 Mar 13;13(3)
RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability.
Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML
bioRxiv : the preprint server for biology 2025 Jul 25;
bioRxiv : the preprint server for biology 2025 Jul 25;
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane.
Zhang X, Tan Y, Li T, Tan D, Fu B, Yang M, Chen Y, Cao M, Xuan C, Du Q, Hu R, Wang Q
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101112
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101112
TDP43 Interacts with MLH1 and MSH6 Proteins in A DNA Damage-Inducible Manner.
Provasek VE, Kodavati M, Kim B, Mitra J, Hegde ML
Research square 2024 May 21;
Research square 2024 May 21;
MRE11A: a novel negative regulator of human DNA mismatch repair.
Du D, Yang Y, Zhang Y, Wang G, Chen L, Guan X, Rasmussen LJ, Liu D
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Cellular & molecular biology letters 2024 Mar 14;29(1):37
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner.
Provasek VE, Kodavati M, Kim B, Mitra J, Hegde ML
Molecular brain 2024 Jun 5;17(1):32
Molecular brain 2024 Jun 5;17(1):32
EZH2 elicits CD8(+) T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.
Zhu CY, Zhai TT, Su M, Pan HC, Tang Q, Huang BH, Chi XR, Li N, Xie LH, Qiu SQ, Pan F, Huang GW
Communications biology 2024 Dec 19;7(1):1645
Communications biology 2024 Dec 19;7(1):1645
The MSH2 c.793-1G>A variant disrupts normal splicing and is associated with Lynch syndrome.
Li Y, Yu L, Cui J, Yin J, Wu W
Frontiers in oncology 2023;13:1131011
Frontiers in oncology 2023;13:1131011
Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.
Wang J, Mi Y, Sun X, Xue X, Zhao H, Zhang M, Hu B, Bukhari I, Zheng P
Aging 2023 Nov 27;15(22):13558-13578
Aging 2023 Nov 27;15(22):13558-13578
Resolution of sequence divergence for repeat-mediated deletions shows a polarity that is mediated by MLH1.
Trost H, Merkell A, Lopezcolorado FW, Stark JM
Nucleic acids research 2023 Jan 25;51(2):650-667
Nucleic acids research 2023 Jan 25;51(2):650-667
Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.
Ran X, Hu T, Li Z
Frontiers in oncology 2022;12:810631
Frontiers in oncology 2022;12:810631
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Shi Y, Jiang J, Cui Y, Chen Y, Dong T, An H, Liu P
DNA and cell biology 2021 Jan;40(1):93-100
DNA and cell biology 2021 Jan;40(1):93-100
CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer.
Zhang H, Xiao X, Wei W, Huang C, Wang M, Wang L, He Y, Sun J, Jiang Y, Jiang G, Zhang X
Molecular cancer 2021 Apr 19;20(1):70
Molecular cancer 2021 Apr 19;20(1):70
PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors.
Tateishi K, Nakamura T, Juratli TA, Williams EA, Matsushita Y, Miyake S, Nishi M, Miller JJ, Tummala SS, Fink AL, Lelic N, Koerner MVA, Miyake Y, Sasame J, Fujimoto K, Tanaka T, Minamimoto R, Matsunaga S, Mukaihara S, Shuto T, Taguchi H, Udaka N, Murata H, Ryo A, Yamanaka S, Curry WT, Dias-Santagata D, Yamamoto T, Ichimura K, Batchelor TT, Chi AS, Iafrate AJ, Wakimoto H, Cahill DP
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jul 15;25(14):4375-4387
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jul 15;25(14):4375-4387
Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma.
Yokota E, Yamatsuji T, Takaoka M, Haisa M, Takigawa N, Miyake N, Ikeda T, Mori T, Ohno S, Sera T, Fukazawa T, Naomoto Y
Oncotarget 2017 Nov 28;8(61):103063-103076
Oncotarget 2017 Nov 28;8(61):103063-103076
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 18120-1-AP(MSH6 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using MSH6 antibody 18120-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 18120-1-AP(MSH6 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 18120-1-AP(MSH6 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
