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- Antibody Data
- Antigen structure
- References [265]
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- Product number
- 23230-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MYD88 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MYD88 antibody (Cat. #23230-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hesperidin-Loaded Nanoparticles Attenuate Pathological Angiogenesis in Oxygen-Induced Retinopathy by Modulating the Retinal Immune Microenvironment.
SC2-3, a Marine Nutrient Glycopeptide from Nereis succinea: Alleviating Cyclophosphamide-Induced Immunocompromise in Mice via M1-Type Macrophage Polarization.
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity.
MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury.
Sprouty2 modulates NF-κB signaling by sequestering the phosphatase PP2Ac in LPS-stimulated macrophages.
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
The Mechanism of Ultrasonic Lysis of Enterococcus faecium F11.1G in Repairing LPS-Induced Inflammatory Damage in IECs via RNA-seq and LC-MS.
Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets.
Protective effects of Curcumin-Zinc complex on inflammatory damage of IPEC-J2 cells induced by bacterial lipopolysaccharide.
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis.
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats.
BMSC-derived exosomal ANTXR1 inhibits erythroid differentiation by suppressing the TLR4/MyD88/NF-κB signaling pathway.
tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.
BAP1 Represses Sequential Activation of IRAKs and NF-κB Signaling in Pancreatic Cancer.
Isodon lophanthoides alleviates liver fibrosis via modulation of purine metabolism and NF-κB signaling pathway: insights from multi-omics analysis.
A novel glucomannan from Bletilla striata ameliorates colitis: Restores intestinal barrier, alleviates inflammation, and modulates the gut flora.
Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota.
Umbilical cord blood-derived exosomes deliver miR-182-5p to Therapeutically target the MYD88/NF-κB signaling pathway in rat peri-implantitis.
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Bovine coronavirus Nsp14 protein promotes viral replication by degrading TRAF3 to inhibit interferon production.
Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'-(thiophen-2-yl)thiourea analogs for potential cancer immunotherapy.
Ginsenoside Rg1 alleviates ochratoxin A-induced liver inflammation in ducklings: Involvement of intestinal microbiota modulation and the TLR4/NF-κB pathway inhibition.
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling.
Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics.
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia.
Ginsenoside Rh2-Liposome Potentiate Vaccine Immunity through Enhanced MHC‑I Presentation.
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid in Escherichia coli-Induced Colitis.
Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-κB p65-mediated immune resistance and STAT3-mediated tissue resilience.
Spike protein-induced VSIR-ISX signaling disrupts metabolic homeostasis and promotes COVID-19-related immune dysfunction.
Polystyrene Nanoplastics Induce DNA Damage and Excitotoxicity in Whole-Brain Organoids: The Role of the TLR9/MyD88 Pathway.
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
Akkermansia muciniphila Akk11 Supplementation Attenuates MPTP-Induced Neurodegeneration by Inhibiting Microglial NLRP3 Inflammasome.
Antihyperuricemic, hepatoprotective and nephroprotective roles of Benincasae Exocarpium in hyperuricemia rats.
Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma.
Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.
Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy.
Atomic Artificial Enzyme for Acute and Chronic Pneumonia.
Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway.
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
Lipopolysaccharide Induces Resistance to CAR-T Cell Therapy of Colorectal Cancer Cells through TGF-β-Mediated Stemness Enhancement.
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Untargeted metabonomics and TLR4/ NF-κB signaling pathway analysis reveals potential mechanism of action of Dendrobium huoshanense polysaccharide in nonalcoholic fatty liver disease.
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development.
The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus.
Clinical Grade Fibroin Sutures with Bioactive Gold Clusters Enhance Surgical Wound Healing via Inflammation Modulation.
Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway.
Effect of Tricin on cardiomyocyte damage caused by diabetic cardiomyopathy (DCM).
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
Dietary Fiber-Derived Butyrate Alleviates Piglet Weaning Stress by Modulating the TLR4/MyD88/NF-κB Pathway.
Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury.
Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie.
SESN1 functions as a new tumor suppressor gene via Toll-like receptor signaling pathway in neuroblastoma.
Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway.
OR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression.
Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites.
Machine learning-based identification of a cell death-related signature associated with prognosis and immune infiltration in glioma.
Saccharomyces boulardii alleviates allergic asthma by restoring gut microbiota and metabolic homeostasis via up-regulation of METTL3 in an m6A-dependent manner.
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase.
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
Resveratrol alleviates heat-stress-induced impairment of the jejunal mucosa through TLR4/MAPK signaling pathway in black-boned chicken.
Gut microbiota regulates host melatonin production through epithelial cell MyD88.
Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway.
The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
Manganese@Albumin Nanocomplex and Its Assembled Nanowire Activate TLR4-Dependent Signaling Cascades of Macrophages.
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis.
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
MiR-525-5p modulates cell proliferation, cell cycle, and apoptosis in Burkitt's lymphoma by targeting MyD88 and regulating the NF-κB signaling pathway.
Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.
Exposure to toluene diisocyanate induces dysbiosis of gut-lung homeostasis: Involvement of gut microbiota.
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Pueraria lobata-Prunus mume Complex Alleviates Alcoholic Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation: A Transcriptome and Gut Microbiota Analysis.
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Exploration the mechanism of Shenling Baizhu San in the treatment of chronic obstructive pulmonary disease based on UPLC-Q-TOF-MS/MS, network pharmacology and in vitro experimental verification.
Huoxiang Zhengqi Oral Liquid Attenuates LPS-Induced Acute Lung Injury by Modulating Short-Chain Fatty Acid Levels and TLR4/NF-κB p65 Pathway.
Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema.
Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice.
Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation.
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis.
Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal injury.
Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-κB pathways.
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF-κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis.
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Artemether Attenuates Gut Barrier Dysfunction and Intestinal Flora Imbalance in High-Fat and High-Fructose Diet-Fed Mice.
Dendritic Cell-Derived Exosomes Stimulated by Treponema pallidum Induce Endothelial Cell Inflammatory Response through the TLR4/MyD88/NF-κB Signaling Pathway.
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice.
Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors.
Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
Therapeutic effect of Atractylenolide I on Aspergillus fumigatus keratitis by affecting MyD88/ NF-κB pathway and IL-1β, IL-10 expression.
Anti-glycation and anti-inflammatory activities of anthocyanins from purple vegetables.
Sulforaphane Ameliorates Nonalcoholic Fatty Liver Disease Induced by High-Fat and High-Fructose Diet via LPS/TLR4 in the Gut-Liver Axis.
Phenylalanine diminishes M1 macrophage inflammation.
Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway.
L-F001, a multifunctional fasudil-lipoic acid dimer, antagonizes hypoxic-ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway.
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
Porcine reproductive and respiratory syndrome virus regulates lipid droplet accumulation in lipid metabolic pathways to promote viral replication.
N protein of PEDV plays chess game with host proteins by selective autophagy.
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation.
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments.
Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist.
Baicalein Ameliorates Myocardial Ischemia Through Reduction of Oxidative Stress, Inflammation and Apoptosis via TLR4/MyD88/MAPK(S)/NF-κB Pathway and Regulation of Ca(2+) Homeostasis by L-type Ca(2+) Channels.
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus.
Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
The role of wheat embryo globulin nutrients in improving cognitive dysfunction in AD rats.
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.
In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides.
Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment.
Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice.
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly.
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
Effects of Artemisinin on Escherichia coli-Induced Mastitis in Bovine Mammary Epithelial Cells and Mice.
The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf.
A positive feed-forward loop between Fusobacterium nucleatum and ethanol metabolism reprogramming drives laryngeal cancer progression and metastasis.
Quercetin ameliorates memory impairment by inhibiting abnormal microglial activation in a mouse model of paradoxical sleep deprivation.
Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats.
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
Clostridium butyricum inhibits the progression of colorectal cancer and alleviates intestinal inflammation via the myeloid differentiation factor 88 (MyD88)-nuclear factor-kappa B (NF-κB) signaling pathway.
Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway.
Gut Microbiota Disorders Promote Inflammation and Aggravate Spinal Cord Injury Through the TLR4/MyD88 Signaling Pathway.
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway.
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38-/- Sepsis Mice.
Zanthoxylum bungeanum Seed Oil Attenuates LPS-Induced BEAS-2B Cell Activation and Inflammation by Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway.
Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model.
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis.
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway.
Intestinal Microbiota Play an Important Role in the Treatment of Type I Diabetes in Mice With BefA Protein.
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell-cell interactions.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats.
The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy.
Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats.
Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets.
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Dietary Ursolic Acid Prevents Alcohol-Induced Liver Injury via Gut-Liver Axis Homeostasis Modulation: The Key Role of Microbiome Manipulation.
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain.
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Astragaloside IV Improves High-Fat Diet-Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.
Pyrroloquinoline Quinone Alleviates Jejunal Mucosal Barrier Function Damage and Regulates Colonic Microbiota in Piglets Challenged With Enterotoxigenic Escherichia coli.
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.
Tumor-derived HMGB1 induces CD62L(dim) neutrophil polarization and promotes lung metastasis in triple-negative breast cancer.
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Targeting Toll-like receptor 4 with CLI-095 (TAK-242) enhances the antimetastatic effect of the estrogen receptor antagonist fulvestrant on non-small cell lung cancer.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model.
Estrogen promotes the metastasis of non‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway.
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation.
Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop.
Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages.
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105.
Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD.
Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway.
Neuroprotective effects of rhynchophylline against ischemic brain injury via regulation of the Akt/mTOR and TLRs signaling pathways.
Wang M, Wang M, Dong C, Chen Y, Liu H, Yao H, Qiming Y, Ran H, Liu D, Zhou X
ACS biomaterials science & engineering 2026 Mar 9;12(3):1826-1847
ACS biomaterials science & engineering 2026 Mar 9;12(3):1826-1847
SC2-3, a Marine Nutrient Glycopeptide from Nereis succinea: Alleviating Cyclophosphamide-Induced Immunocompromise in Mice via M1-Type Macrophage Polarization.
Liu Y, Huang Y, Li J, Zhang Y, Wang P
Foods (Basel, Switzerland) 2026 Mar 4;15(5)
Foods (Basel, Switzerland) 2026 Mar 4;15(5)
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity.
Xu J, Wang W, Zhou Y, Zhang H, Shang Z, Zhang Z, Li B, Bai Y, Zhang J
Microorganisms 2026 Mar 23;14(3)
Microorganisms 2026 Mar 23;14(3)
MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury.
Siddique R, Guo P, Wang Q, Su Q, Qi L, Mazhar M, Aaqib M, Zhang X, Khan S, Yong VW, Xue M
Journal of advanced research 2026 Mar 23;
Journal of advanced research 2026 Mar 23;
Sprouty2 modulates NF-κB signaling by sequestering the phosphatase PP2Ac in LPS-stimulated macrophages.
Sripada A, Varma R, Sirohi K, Sahu A, Verma M, Alam R
Journal of immunology (Baltimore, Md. : 1950) 2026 Mar 17;215(3)
Journal of immunology (Baltimore, Md. : 1950) 2026 Mar 17;215(3)
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Zhang Y, Luo X, Wu S, Qin Y, Xue Q, Ye W, Hou S, Liu B, Huang D, Yuan W, Ao H, Tong G, Liao M
Journal of ethnopharmacology 2026 Jun 28;365:121585
Journal of ethnopharmacology 2026 Jun 28;365:121585
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
Liu X, Wang S, Kuang C, Deng Y, Yuan S, Zou J
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
The Mechanism of Ultrasonic Lysis of Enterococcus faecium F11.1G in Repairing LPS-Induced Inflammatory Damage in IECs via RNA-seq and LC-MS.
Bai T, Zhang Y, E G, Zhang M, Guo X, Liu J
Cells 2026 Jan 6;15(2)
Cells 2026 Jan 6;15(2)
Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets.
Zhang L, Wu Z, Shen H, Meng Y, Li H, Cai R, Tang D, Kang M, Yin Y, Tan B, Wang J
Microbiome 2026 Jan 6;14(1):55
Microbiome 2026 Jan 6;14(1):55
Protective effects of Curcumin-Zinc complex on inflammatory damage of IPEC-J2 cells induced by bacterial lipopolysaccharide.
Tang X, Zeng Y, Li M
AMB Express 2026 Jan 3;16(1):13
AMB Express 2026 Jan 3;16(1):13
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Ma Y, Zhang J, Gong J, Yang W, Huang J, Sun Y
Journal of ethnopharmacology 2026 Jan 10;354:120580
Journal of ethnopharmacology 2026 Jan 10;354:120580
Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis.
Hu Z, Liu H, Wu W, Ali T, Junka A, Sharopov FS, Zou X, Fang S, Sun Y
Pharmaceuticals (Basel, Switzerland) 2026 Feb 6;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 6;19(2)
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
Cao D, Jia J, Yin Y, Lu W
International journal of molecular sciences 2026 Feb 26;27(5)
International journal of molecular sciences 2026 Feb 26;27(5)
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
Zhu Y, Chen L, Lin J, Chen M, Wu W, Chen Y, Xuan L
Journal of ethnopharmacology 2026 Feb 10;356:120656
Journal of ethnopharmacology 2026 Feb 10;356:120656
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats.
Zhao WP, Zhu SQ, Yin ZH, Ommati MM, Zhang YW, Zhao J, Zhou BH, Wang HW
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127503
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127503
BMSC-derived exosomal ANTXR1 inhibits erythroid differentiation by suppressing the TLR4/MyD88/NF-κB signaling pathway.
Chen D, Lin L, Wu Y, Huang K, Zhang H, Chen Q
Scientific reports 2026 Apr 16;
Scientific reports 2026 Apr 16;
tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.
Wang C, Yu B, Zhou H, Li H, Li S, Li X, Wang W, Feng Y, Yu T
Research (Washington, D.C.) 2025;8:0574
Research (Washington, D.C.) 2025;8:0574
BAP1 Represses Sequential Activation of IRAKs and NF-κB Signaling in Pancreatic Cancer.
Zhao Y, Liang X, Wei R, Guo F, Qin G, Yu H, Liu J, Xia W, Gou S, Wu H, Zhou Y
International journal of biological sciences 2025;21(5):1949-1965
International journal of biological sciences 2025;21(5):1949-1965
Isodon lophanthoides alleviates liver fibrosis via modulation of purine metabolism and NF-κB signaling pathway: insights from multi-omics analysis.
Chen K, Liang J, Tan Y, Li Y, Pan X, Guo Z, Zhang W, Sun Z
Frontiers in pharmacology 2025;16:1630927
Frontiers in pharmacology 2025;16:1630927
A novel glucomannan from Bletilla striata ameliorates colitis: Restores intestinal barrier, alleviates inflammation, and modulates the gut flora.
Sun X, Zhang T, Zhao Y, Yang H, Li Y, Sun X, Bian X
International journal of biological macromolecules 2025 Sep;321(Pt 3):146421
International journal of biological macromolecules 2025 Sep;321(Pt 3):146421
Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota.
Yang L, Ni H, Gou X, Zhong B, Wen K, Zhang Y, Zhang S, Wang Y
Food science & nutrition 2025 Sep;13(9):e70989
Food science & nutrition 2025 Sep;13(9):e70989
Umbilical cord blood-derived exosomes deliver miR-182-5p to Therapeutically target the MYD88/NF-κB signaling pathway in rat peri-implantitis.
Liu H, Zhu D, Lang L, Liu M, Yang Z, Zhang Z, Shen Z
Materials today. Bio 2025 Oct;34:102246
Materials today. Bio 2025 Oct;34:102246
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Gan H, Gong M, Wang L, Huang X, Chen Y, Hu Z, Li X, Zeng Q
Food science & nutrition 2025 Oct;13(10):e71064
Food science & nutrition 2025 Oct;13(10):e71064
Bovine coronavirus Nsp14 protein promotes viral replication by degrading TRAF3 to inhibit interferon production.
Sun H, Liu Y, Yang X, Qin W, Lu X, Wang Y, Tong W, Yu H, Zheng H, Tong G, Shan T, Kong N
Veterinary microbiology 2025 Nov;310:110708
Veterinary microbiology 2025 Nov;310:110708
Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'-(thiophen-2-yl)thiourea analogs for potential cancer immunotherapy.
Zeng X, Fu Q, Liao R, Mei H, Huang L, Zhu Z, Cheng K, Chen Z
European journal of medicinal chemistry 2025 Nov 5;297:117968
European journal of medicinal chemistry 2025 Nov 5;297:117968
Ginsenoside Rg1 alleviates ochratoxin A-induced liver inflammation in ducklings: Involvement of intestinal microbiota modulation and the TLR4/NF-κB pathway inhibition.
Zhai S, Peng X, Liu C, Zhang R, Jin C, Jiang X, Feng P, Liang Y, Yuan X, Zhang J, Yang Y
Ecotoxicology and environmental safety 2025 May;296:118186
Ecotoxicology and environmental safety 2025 May;296:118186
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Wang Y, Ma Y, Tuo P, Naeem A, Tang Y, Su Q, Li H, Gao X, Wang X
Phytotherapy research : PTR 2025 May 8;
Phytotherapy research : PTR 2025 May 8;
Multi-Omics Unveils Inflammatory Regulation of Fermented Sini Decoction Dregs in Broilers Infected with Avian Pathogenic Escherichia coli.
Mo S, Fang X, Xiao W, Huang B, Li C, Yang H, Wu Y, Wang Y, Ma H
Veterinary sciences 2025 May 15;12(5)
Veterinary sciences 2025 May 15;12(5)
Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling.
Liu P, Deng J, Yang Y, Bai W, Dong S, Zhang Z
iScience 2025 Mar 21;28(3):112107
iScience 2025 Mar 21;28(3):112107
Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics.
Zhang X, Zhang J, Xun G, Gao Y, Zhao J, Fu Y, Su S, Kong D, Wang Q, Wang X
Journal of ethnopharmacology 2025 Mar 13;343:119485
Journal of ethnopharmacology 2025 Mar 13;343:119485
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Wang K, Shi G, Li Y, Liu Q, Zhang Q, Wu C, Jiao Y, Ma Y, Qi A, Huang M
Environmental toxicology and pharmacology 2025 Jun;116:104706
Environmental toxicology and pharmacology 2025 Jun;116:104706
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
Cao J, Yao M, Wang K, Qin L, Zhang Q, Zhang H, Wei J, Qu C, Xue C, Miao J
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia.
Lei X, Ran X, Wang J, Li L, Wu N, Ru X, Wang P, Li X, Li W, Huang Y
Life sciences 2025 Jun 1;370:123571
Life sciences 2025 Jun 1;370:123571
Ginsenoside Rh2-Liposome Potentiate Vaccine Immunity through Enhanced MHC‑I Presentation.
Nie Q, Chen Z, Gong W, Cao W, Wang X, Liu Y, Zhang S, Yang Y, Meng Z
ACS omega 2025 Jul 29;10(29):31940-31953
ACS omega 2025 Jul 29;10(29):31940-31953
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
Li D, Li H, Wang Z, Huang Y, Zhao C, Zhang H, Zhao Y, Zhu N, Tang X, Jin Y, Zhou D
Veterinary research 2025 Jul 21;56(1):155
Veterinary research 2025 Jul 21;56(1):155
Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.
Yang L, Hua M, Li D, Li F, He Y, Miao X, Sun M, Niu H, An F, Wang J, Yang M, Lu J, Xu H, Wang J
Journal of microbiology and biotechnology 2025 Jul 14;35:e2502013
Journal of microbiology and biotechnology 2025 Jul 14;35:e2502013
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Ling F, Chen Y, Li J, Xu M, Song G, Tu L, Wang H, Li S, Zhu L
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
Gao H, Sun M, Gao H, Sun Y, Chen W, Dong N
International immunopharmacology 2025 Jan 3;145:113781
International immunopharmacology 2025 Jan 3;145:113781
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
Li B, Liu M, Du W, Wang S, Xu Z, Zhang X, Zhang Y, Hua S
BMC veterinary research 2025 Jan 29;21(1):39
BMC veterinary research 2025 Jan 29;21(1):39
The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid in Escherichia coli-Induced Colitis.
Wang K, Hu Y, Wu Y, Xu J, Zhao Y, Yang J, Li X
International journal of molecular sciences 2025 Feb 25;26(5)
International journal of molecular sciences 2025 Feb 25;26(5)
Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-κB p65-mediated immune resistance and STAT3-mediated tissue resilience.
Xu Z, Wang K, Hu H, Hu Y, Huang J, Luo Z
International immunopharmacology 2025 Feb 20;148:114101
International immunopharmacology 2025 Feb 20;148:114101
Spike protein-induced VSIR-ISX signaling disrupts metabolic homeostasis and promotes COVID-19-related immune dysfunction.
Wang LT, Wang SN, Chiou SS, Chai CY, Hsu SH
Cell biology and toxicology 2025 Dec 19;42(1):2
Cell biology and toxicology 2025 Dec 19;42(1):2
Polystyrene Nanoplastics Induce DNA Damage and Excitotoxicity in Whole-Brain Organoids: The Role of the TLR9/MyD88 Pathway.
Wei Y, Cao G, Ma J, Mi Y, Zhao Y, Zhang L, Wang B, Liu H, Li K, Shi Y, Lai W, Tian L, Lin B
Toxics 2025 Dec 19;14(1)
Toxics 2025 Dec 19;14(1)
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
Yan J, Cai J, Pan X, Li S, Fenton CG, Fenton KA, Kantarci A, Xue Y, Xue Y, Xing Z
Biomedicines 2025 Dec 10;13(12)
Biomedicines 2025 Dec 10;13(12)
Akkermansia muciniphila Akk11 Supplementation Attenuates MPTP-Induced Neurodegeneration by Inhibiting Microglial NLRP3 Inflammasome.
Wang W, Shi S, Su M, Li Y, Yao X, Jiang J, Yao W, Qin X, Wang Z, Tang C
Probiotics and antimicrobial proteins 2025 Aug;17(4):2348-2361
Probiotics and antimicrobial proteins 2025 Aug;17(4):2348-2361
Antihyperuricemic, hepatoprotective and nephroprotective roles of Benincasae Exocarpium in hyperuricemia rats.
Tong R, Ding B, Chen S, Yang W, Yi Y, He W, Zhou R, Wang Y, Li W, Qin S
Journal of ethnopharmacology 2025 Aug 29;352:120185
Journal of ethnopharmacology 2025 Aug 29;352:120185
Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma.
Li G, Zhao Y, He Y, Qian Z, Liu Y, Li X, Li L, Liu Z
Scientific reports 2025 Aug 19;15(1):30417
Scientific reports 2025 Aug 19;15(1):30417
Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.
You M, Zhang Y, Gao M, Zhao W, Wei L, Ruan XZ, Chen Y
Free radical biology & medicine 2025 Aug 16;236:144-159
Free radical biology & medicine 2025 Aug 16;236:144-159
Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy.
Chen S, Yin W, Zhi H, Zhang X, An L, Yang Z, Li R, Cai Y, You C, Li Y, Li Y, Dong H
Journal of controlled release : official journal of the Controlled Release Society 2025 Aug 10;384:113956
Journal of controlled release : official journal of the Controlled Release Society 2025 Aug 10;384:113956
Atomic Artificial Enzyme for Acute and Chronic Pneumonia.
Liu W, Liu D, Cui T, Wang Y, Zhou S, Tian F, Yang K, Wang W, Bi L, Fan K, Li L, Wang H, Zhang XD
Advanced healthcare materials 2025 Apr;14(9):e2402364
Advanced healthcare materials 2025 Apr;14(9):e2402364
Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway.
Mao Z, Lin X, Hu Y, Liu Y, Yu S, Zhou T, Zhang J, Yang X, Tian S, Miao M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156496
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156496
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
An Y, Tu Z, Wang A, Gou W, Yu H, Wang X, Xu F, Li Y, Wang C, Li J, Zhang M, Xiao M, Di Y, Hou W, Cui Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
Lipopolysaccharide Induces Resistance to CAR-T Cell Therapy of Colorectal Cancer Cells through TGF-β-Mediated Stemness Enhancement.
Tao M, Xue M, Zhou D, Zhang L, Hou X, Zhu X, Feng S, Yan H, Qian X, Wei L, Zong C, Yang X, Zhang L
Molecular pharmaceutics 2025 Apr 7;22(4):1790-1803
Molecular pharmaceutics 2025 Apr 7;22(4):1790-1803
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Nie X, Miao S, Hou Y, Ma Y, Li M, Liu Y, Yang Y, Xu J, Wang Y
International immunopharmacology 2025 Apr 16;152:114346
International immunopharmacology 2025 Apr 16;152:114346
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
Untargeted metabonomics and TLR4/ NF-κB signaling pathway analysis reveals potential mechanism of action of Dendrobium huoshanense polysaccharide in nonalcoholic fatty liver disease.
Deng GH, Zhao CC, Cai X, Zhang XQ, Ma MZ, Lv JH, Jiang WL, Peng DY, Wang YY, Xing LH, Yu NJ
Frontiers in pharmacology 2024;15:1374158
Frontiers in pharmacology 2024;15:1374158
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
Zhu J, Zhao H, Aierken A, Zhou T, Menggen M, Gao H, He R, Aimulajiang K, Wen H
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Yuan K, Yang Y, Lin Y, Zhou F, Huang K, Yang S, Kong W, Li F, Kan T, Wang Y, Cheng C, Liang Y, Chang H, Huang J, Ao H, Yu Z, Li H, Liu Y, Tang T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Ma X, Xie J, Li B, Shan H, Jia Z, Liu W, Dong Y, Han S, Jin Q
International immunopharmacology 2024 Oct 25;140:112761
International immunopharmacology 2024 Oct 25;140:112761
Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development.
Shen J, Ji Xz, Han L, Yao J, Liang Y, Yuan M, Xu S, Li Z
mSystems 2024 Oct 22;9(10):e0089324
mSystems 2024 Oct 22;9(10):e0089324
The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus.
Li Z, Zhang L, Liu Y, Li H, Gong L, Tan X, Tian J, Pi H, Wang B, Zhao Y, Liu D
iScience 2024 Oct 18;27(10):111038
iScience 2024 Oct 18;27(10):111038
Clinical Grade Fibroin Sutures with Bioactive Gold Clusters Enhance Surgical Wound Healing via Inflammation Modulation.
Tian F, Zhang S, Wang M, Yan Y, Cao Y, Wang Y, Fan K, Wang H, Zhang J, Zhang XD
ACS applied materials & interfaces 2024 Oct 16;16(41):55097-55106
ACS applied materials & interfaces 2024 Oct 16;16(41):55097-55106
Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway.
Qu L, Huang Y, Wu Y, He L, Liu Y, Chen Z, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24387-24399
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24387-24399
Effect of Tricin on cardiomyocyte damage caused by diabetic cardiomyopathy (DCM).
Yu R, Zhang Y, Wang T, Duan J, Li X
BMC cardiovascular disorders 2024 Nov 23;24(1):668
BMC cardiovascular disorders 2024 Nov 23;24(1):668
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
He J, He Z, Wang H, Zhang C, Pei T, Yan S, Yan Y, Wang F, Chen Y, Yuan N, Wang M, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
Dietary Fiber-Derived Butyrate Alleviates Piglet Weaning Stress by Modulating the TLR4/MyD88/NF-κB Pathway.
Huangfu W, Ma J, Zhang Y, Liu M, Liu B, Zhao J, Wang Z, Shi Y
Nutrients 2024 May 30;16(11)
Nutrients 2024 May 30;16(11)
Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury.
Xu X, Sun K, Chang H, Shen C, Li X, Ni Y, Zhu Y, Wang H, Xiong R, Padde JR, Xu Z, Chen L, Chen L, Hou M, Pu L, Ji M
Journal of biomedical research 2024 May 29;39(1):61-75
Journal of biomedical research 2024 May 29;39(1):61-75
Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie.
Tian M, Sun W, Mao Y, Zhang Y, Liu H, Tang Y
Briefings in bioinformatics 2024 May 23;25(4)
Briefings in bioinformatics 2024 May 23;25(4)
SESN1 functions as a new tumor suppressor gene via Toll-like receptor signaling pathway in neuroblastoma.
Hua Z, Chen B, Gong B, Lin M, Ma Y, Li Z
CNS neuroscience & therapeutics 2024 Mar;30(3):e14664
CNS neuroscience & therapeutics 2024 Mar;30(3):e14664
Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.
Zhang X, Gao M, Zhao X, Qi Y, Xu L, Yin L, Peng J
International journal of biological macromolecules 2024 Mar;260(Pt 1):129455
International journal of biological macromolecules 2024 Mar;260(Pt 1):129455
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
Peng Z, Li XJ, Zhou Y, Zhang JT, Zhu Q, Sun JQ, Hang CH, Li W, Zhang QR, Zhuang Z
Free radical biology & medicine 2024 Mar;215:79-93
Free radical biology & medicine 2024 Mar;215:79-93
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway.
Lu D, Liu W, Yang H, Zong Y, Sun J, Sun X, Song S, Liu M, Kan J, Che C
Cytokine 2024 Mar;175:156483
Cytokine 2024 Mar;175:156483
OR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression.
Li X, Wang G, Wang X, Li W, Li N, Liu X, Fan W, He S, Han Y, Su G, Cao Q, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306563
Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites.
He X, Liang J, Li X, Wang Y, Zhang X, Chen D, Wu L, Wang S
Journal of ethnopharmacology 2024 Mar 1;321:117402
Journal of ethnopharmacology 2024 Mar 1;321:117402
Machine learning-based identification of a cell death-related signature associated with prognosis and immune infiltration in glioma.
Zhou Q, Wu F, Zhang W, Guo Y, Jiang X, Yan X, Ke Y
Journal of cellular and molecular medicine 2024 Jun;28(11):e18463
Journal of cellular and molecular medicine 2024 Jun;28(11):e18463
Saccharomyces boulardii alleviates allergic asthma by restoring gut microbiota and metabolic homeostasis via up-regulation of METTL3 in an m6A-dependent manner.
Liu D, Hu L, Yang Y, Wang Y, Li Y, Su J, Wang G, Gong S
Immunology letters 2024 Jun;267:106853
Immunology letters 2024 Jun;267:106853
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Bai X, Deng J, Duan Z, Fu R, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
Zhao Q, Chen L, Zhang X, Yang H, Li Y, Li P
Chinese medicine 2024 Jun 15;19(1):86
Chinese medicine 2024 Jun 15;19(1):86
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase.
Lou Y, Li Z, Zheng H, Yuan Z, Li W, Zhang J, Shen W, Gao Y, Ran N, Kong X, Feng S
International immunopharmacology 2024 Jun 15;134:112190
International immunopharmacology 2024 Jun 15;134:112190
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
Li Y, Xu C, Han H, Pascual-Sabater S, Fillat C, Goel A
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
Resveratrol alleviates heat-stress-induced impairment of the jejunal mucosa through TLR4/MAPK signaling pathway in black-boned chicken.
Liu L, Gong X, Zhang X, Zhang D, Tang Y, Liu J, Li Y, Pan D
Poultry science 2024 Jan;103(1):103242
Poultry science 2024 Jan;103(1):103242
Gut microbiota regulates host melatonin production through epithelial cell MyD88.
Liu B, Fan L, Wang Y, Wang H, Yan Y, Chen S, Hung I, Liu C, Wei H, Ge L, Ren W
Gut microbes 2024 Jan-Dec;16(1):2313769
Gut microbes 2024 Jan-Dec;16(1):2313769
Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway.
Du Y, Yan T, Wu B, He B, Jia Y
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117190
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117190
The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.
Huang L, Xie S, Zhang Y, Du W, Liang X, Pan W, Yang F, Niu R, Chen H, Geng L, Xiang L, Gong S, Xu W
Life sciences 2024 Jan 15;337:122348
Life sciences 2024 Jan 15;337:122348
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
Huang H, Sun Z, Xu J, Wang L, Zhao J, Li J, Zhang S, Yuan F, Liu M, Fang Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
Manganese@Albumin Nanocomplex and Its Assembled Nanowire Activate TLR4-Dependent Signaling Cascades of Macrophages.
Huang S, Gao Y, Li H, Wang R, Zhang X, Wang X, Huang D, Zhang L, Santos HA, Yin Z, Xia B
Advanced materials (Deerfield Beach, Fla.) 2024 Feb;36(5):e2310979
Advanced materials (Deerfield Beach, Fla.) 2024 Feb;36(5):e2310979
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Wang G, Li R, Feng C, Li K, Liu S, Fu Q
Cell death discovery 2024 Feb 20;10(1):92
Cell death discovery 2024 Feb 20;10(1):92
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6
Molecular cell 2024 Feb 15;84(4):744-759.e6
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Wang JH, Mao HB, Hu JB, Cheng S, Su H
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis.
Liu Y, Li X, Guo Z, Li G, He L, Liu H, Cai S, Huo T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156216
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
Wu D, Lin Q, Wang Z, Huang H, Song X, Gao Y, Yang X, Wen K, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
MiR-525-5p modulates cell proliferation, cell cycle, and apoptosis in Burkitt's lymphoma by targeting MyD88 and regulating the NF-κB signaling pathway.
Chen Y, Gao B, Pan Y, Wang Q, Zhang Q
Annals of hematology 2024 Dec;103(12):5817-5833
Annals of hematology 2024 Dec;103(12):5817-5833
Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
Yang J, Cai JH, Wu TX, Gao ZQ, Zhou C, Wu Q, Ji MJ
Journal of ethnopharmacology 2024 Dec 5;335:118697
Journal of ethnopharmacology 2024 Dec 5;335:118697
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Liu L, Zheng C, Xu Z, Wang Z, Zhong Y, He Z, Zhang W, Zhang Y
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.
Xu Y, Cai Q, Zhao C, Zhang W, Xu X, Lin H, Lin Y, Chen D, Lin S, Jia P, Wang M, Zhang L, Lin W
Pharmaceuticals (Basel, Switzerland) 2024 Dec 25;18(1)
Pharmaceuticals (Basel, Switzerland) 2024 Dec 25;18(1)
Exposure to toluene diisocyanate induces dysbiosis of gut-lung homeostasis: Involvement of gut microbiota.
Gou Y, Lin F, Dan L, Zhang D
Environmental pollution (Barking, Essex : 1987) 2024 Dec 15;363(Pt 1):125119
Environmental pollution (Barking, Essex : 1987) 2024 Dec 15;363(Pt 1):125119
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis.
Guo Y, Du X, Wang F, Fu Y, Guo X, Meng R, Ge K, Zhang S
Ecotoxicology and environmental safety 2024 Aug;281:116629
Ecotoxicology and environmental safety 2024 Aug;281:116629
Pueraria lobata-Prunus mume Complex Alleviates Alcoholic Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation: A Transcriptome and Gut Microbiota Analysis.
Gao R, Huang Q, Zeng Y, Chen D, Jia Z, Han B, Huang X, Wang Q, Hu X, Liao M, Li J
Foods (Basel, Switzerland) 2024 Aug 1;13(15)
Foods (Basel, Switzerland) 2024 Aug 1;13(15)
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Zhang S, Zhao N, Song S, Wang Y, Wang Y, Sun C, Dong M, Huo M, Xu N, Liu W, Li G
Toxicology and applied pharmacology 2024 Apr;485:116890
Toxicology and applied pharmacology 2024 Apr;485:116890
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Wu J, Huang H, Gong L, Tian X, Peng Z, Zhu Y, Wang W
Biomolecules 2024 Apr 7;14(4)
Biomolecules 2024 Apr 7;14(4)
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Ullah H, Shi X, Taj A, Cheng L, Yan Q, Sha S, Ahmad, Kang J, Haris M, Ma X, Ma Y
Biology 2024 Apr 30;13(5)
Biology 2024 Apr 30;13(5)
Exploration the mechanism of Shenling Baizhu San in the treatment of chronic obstructive pulmonary disease based on UPLC-Q-TOF-MS/MS, network pharmacology and in vitro experimental verification.
Gao Z, Wang J, Lu G, Wu Q, Wang S, Wu X, Ou C, Wu Z, Yu H, Wang Y
Journal of ethnopharmacology 2024 Apr 24;324:117728
Journal of ethnopharmacology 2024 Apr 24;324:117728
Huoxiang Zhengqi Oral Liquid Attenuates LPS-Induced Acute Lung Injury by Modulating Short-Chain Fatty Acid Levels and TLR4/NF-κB p65 Pathway.
Tang R, Zhang J, Zhang R, Li X, Lv R, Nan H, Liu J, Zhao Z, He W, Wang L
BioMed research international 2023;2023:6183551
BioMed research international 2023;2023:6183551
Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema.
Cui Y, Hu J, Li Y, Au R, Fang Y, Cheng C, Xu F, Li W, Wu Y, Zhu L, Shen H
Drug design, development and therapy 2023;17:3453-3472
Drug design, development and therapy 2023;17:3453-3472
Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice.
Dong WR, Li YY, Liu TT, Zhou G, Chen YX
Frontiers in pharmacology 2023;14:1229772
Frontiers in pharmacology 2023;14:1229772
Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation.
Yang J, Pan Y, Zeng X, Liu S, Chen Z, Cheng K
Acta pharmaceutica Sinica. B 2023 Sep;13(9):3782-3801
Acta pharmaceutica Sinica. B 2023 Sep;13(9):3782-3801
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Wang Z, Zhu D, Zhang Y, Xia F, Zhu J, Dai J, Zhuge X
Microbial cell factories 2023 Sep 9;22(1):177
Microbial cell factories 2023 Sep 9;22(1):177
Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis.
Zhao Q, Hao Y, Yang X, Mao J, Tian F, Gao Y, Tian X, Yan X, Qiu Y
Journal of hazardous materials 2023 Sep 5;457:131816
Journal of hazardous materials 2023 Sep 5;457:131816
Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal injury.
Huang B, Gui M, An H, Shen J, Ye F, Ni Z, Zhan H, Che L, Lai Z, Zeng J, Peng J, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115387
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115387
Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-κB pathways.
Yin J, Hu T, Xu L, Zhang L, Zhu J, Ye Y, Pang Z
International immunopharmacology 2023 Oct;123:110763
International immunopharmacology 2023 Oct;123:110763
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
Sahanic S, Hilbe R, Dünser C, Tymoszuk P, Löffler-Ragg J, Rieder D, Trajanoski Z, Krogsdam A, Demetz E, Yurchenko M, Fischer C, Schirmer M, Theurl M, Lener D, Hirsch J, Holfeld J, Gollmann-Tepeköylü C, Zinner CP, Tzankov A, Zhang SY, Casanova JL, Posch W, Wilflingseder D, Weiss G, Tancevski I
Heliyon 2023 Nov;9(11):e21893
Heliyon 2023 Nov;9(11):e21893
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF-κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis.
Shi P, Zhu W, Fu J, Liang A, Zheng T, Wen Z, Wu X, Peng Y, Yuan S, Wu X
Journal of cellular and molecular medicine 2023 Nov;27(21):3326-3338
Journal of cellular and molecular medicine 2023 Nov;27(21):3326-3338
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Ma MH, Gao LL, Chen CB, Gu FL, Wu SQ, Li F, Han BX
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Artemether Attenuates Gut Barrier Dysfunction and Intestinal Flora Imbalance in High-Fat and High-Fructose Diet-Fed Mice.
Ren X, Xu J, Xu Y, Wang Q, Huang K, He X
Nutrients 2023 Nov 21;15(23)
Nutrients 2023 Nov 21;15(23)
Dendritic Cell-Derived Exosomes Stimulated by Treponema pallidum Induce Endothelial Cell Inflammatory Response through the TLR4/MyD88/NF-κB Signaling Pathway.
Zhang R, Lian T, Liu J, Du F, Chen Z, Zhang R, Wang Q
ACS infectious diseases 2023 Nov 10;9(11):2299-2305
ACS infectious diseases 2023 Nov 10;9(11):2299-2305
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Zhang Z, Guo L, Yang F, Peng S, Wang D, Lai X, Su B, Xie H
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L, Zhang L, Hou S
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice.
Farini A, Tripodi L, Villa C, Strati F, Facoetti A, Baselli G, Troisi J, Landolfi A, Lonati C, Molinaro D, Wintzinger M, Gatti S, Cassani B, Caprioli F, Facciotti F, Quattrocelli M, Torrente Y
EMBO molecular medicine 2023 Mar 8;15(3):e16244
EMBO molecular medicine 2023 Mar 8;15(3):e16244
Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors.
Zhao S, Hu S, Sun K, Luo L, Zeng L
Food & function 2023 Mar 6;14(5):2313-2325
Food & function 2023 Mar 6;14(5):2313-2325
Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway.
Wang SH, Huang SH, Hsieh MC, Lu IC, Chou PR, Tai MH, Wu SH
International journal of molecular sciences 2023 Mar 11;24(6)
International journal of molecular sciences 2023 Mar 11;24(6)
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
Cui Y, Zhang F, Xu W, Li Z, Zou J, Gao P, Hu J
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway.
Luo Y, Yang Y, Wang W, Gao Q, Gong T, Feng Y, Wu D, Zheng X, Zhang G, Wang H
Virology journal 2023 Jul 19;20(1):158
Virology journal 2023 Jul 19;20(1):158
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Zhang JW, Zhang D, Yin HS, Zhang H, Hong KQ, Yuan JP, Yu BP
Gut microbes 2023 Jan-Dec;15(1):2197836
Gut microbes 2023 Jan-Dec;15(1):2197836
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
Wang L, Yan H, Chen X, Han L, Liu G, Yang H, Lu D, Liu W, Che C
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
Therapeutic effect of Atractylenolide I on Aspergillus fumigatus keratitis by affecting MyD88/ NF-κB pathway and IL-1β, IL-10 expression.
Chen X, Lu D, Liu W, Xie J, Lu Z, Yang H, Yan H, Wang L, Che C
Cytokine 2023 Feb;162:156112
Cytokine 2023 Feb;162:156112
Anti-glycation and anti-inflammatory activities of anthocyanins from purple vegetables.
Gao Q, Ma R, Shi L, Wang S, Liang Y, Zhang Z
Food & function 2023 Feb 21;14(4):2034-2044
Food & function 2023 Feb 21;14(4):2034-2044
Sulforaphane Ameliorates Nonalcoholic Fatty Liver Disease Induced by High-Fat and High-Fructose Diet via LPS/TLR4 in the Gut-Liver Axis.
Xu Y, Huang X, Huangfu B, Hu Y, Xu J, Gao R, Huang K, He X
Nutrients 2023 Feb 1;15(3)
Nutrients 2023 Feb 1;15(3)
Phenylalanine diminishes M1 macrophage inflammation.
Zhang Q, Chen S, Guo Y, He F, Fu J, Ren W
Science China. Life sciences 2023 Dec;66(12):2862-2876
Science China. Life sciences 2023 Dec;66(12):2862-2876
Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway.
Du Y, He B, Wu B, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Dec;134:102349
Journal of chemical neuroanatomy 2023 Dec;134:102349
L-F001, a multifunctional fasudil-lipoic acid dimer, antagonizes hypoxic-ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway.
Zhou R, Wu L, Jin N, Sha S, Ouyang Y
Brain and behavior 2023 Dec;13(12):e3280
Brain and behavior 2023 Dec;13(12):e3280
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
He X, Liu J, Jiang K, Lian S, Shi Y, Fu S, Zhao P, Xiao J, Sun D, Guo D
Anaerobe 2023 Aug;82:102768
Anaerobe 2023 Aug;82:102768
Porcine reproductive and respiratory syndrome virus regulates lipid droplet accumulation in lipid metabolic pathways to promote viral replication.
Yang Y, Luo Y, Yi S, Gao Q, Gong T, Feng Y, Wu D, Zheng X, Wang H, Zhang G, Sun Y
Virus research 2023 Aug;333:199139
Virus research 2023 Aug;333:199139
N protein of PEDV plays chess game with host proteins by selective autophagy.
Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352
Autophagy 2023 Aug;19(8):2338-2352
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
Xu Z, Zhang G, Zhang X, Lei Y, Sun Y, He Y, Yang F, Nan W, Xing X, Li Y, Lin J
The international journal of biochemistry & cell biology 2023 Apr;157:106386
The international journal of biochemistry & cell biology 2023 Apr;157:106386
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Zhang X, Yang X, Zhang S, Wang J, Wang M, Ma T, Wan M, Lv X, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation.
Xie Z, Zhang G, Liu R, Wang Y, Tsapieva AN, Zhang L, Han J
Nutrients 2023 Apr 4;15(7)
Nutrients 2023 Apr 4;15(7)
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Zhang H, Zuo Y, Zhao H, Zhao H, Wang Y, Zhang X, Zhang J, Wang P, Sun L, Zhang H, Liang H
Frontiers in nutrition 2022;9:989311
Frontiers in nutrition 2022;9:989311
Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments.
Xu X, Li N, Wu Y, Yan K, Mi Y, Yi N, Tan X, Kuang G, Lu M
Frontiers in pharmacology 2022;13:951860
Frontiers in pharmacology 2022;13:951860
Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist.
Liu X, Yao JJ, Chen Z, Lei W, Duan R, Yao Z
Frontiers in immunology 2022;13:906357
Frontiers in immunology 2022;13:906357
Baicalein Ameliorates Myocardial Ischemia Through Reduction of Oxidative Stress, Inflammation and Apoptosis via TLR4/MyD88/MAPK(S)/NF-κB Pathway and Regulation of Ca(2+) Homeostasis by L-type Ca(2+) Channels.
Li J, Yang Y, Wang H, Ma D, Wang H, Chu L, Zhang Y, Gao Y
Frontiers in pharmacology 2022;13:842723
Frontiers in pharmacology 2022;13:842723
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137
Frontiers in pharmacology 2022;13:1096137
Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus.
Wen Z, Zhang Y, Feng J, Aimulajiang K, Aleem MT, Lu M, Xu L, Song X, Li X, Yan R
Frontiers in immunology 2022;13:1013159
Frontiers in immunology 2022;13:1013159
Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway.
Liu C, Liu Y, Wang C, Guo Y, Cheng Y, Qian H, Zhao Y
Foods (Basel, Switzerland) 2022 Sep 30;11(19)
Foods (Basel, Switzerland) 2022 Sep 30;11(19)
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.
Hu J, Tong Y, Shen Z, Li Y, Cheng C, Au R, Xu F, Liu Y, Zhu L, Shen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113571
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113571
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
Xiao S, Zhong N, Yang Q, Li A, Tong W, Zhang Y, Yao G, Wang S, Liu J, Liu Z
International immunopharmacology 2022 Oct;111:109163
International immunopharmacology 2022 Oct;111:109163
The role of wheat embryo globulin nutrients in improving cognitive dysfunction in AD rats.
Zheng S, Pan L, Hou J, Liao A, Hou Y, Yu G, Li X, Yuan Y, Dong Y, Zhao P, Zhang J, Hu Z, Hui M, Cao J, Huang JH
Food & function 2022 Oct 3;13(19):9856-9867
Food & function 2022 Oct 3;13(19):9856-9867
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.
Yuan X, Wang R, Han B, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Xu Z, Fu J, Wu J, Gu W, Chen Z, Fang X, Yang H, Su Z, Wu J, Li Q, Zhang M, Zhou Y, Zhang L, Ji G, Luo F
Nature communications 2022 Oct 26;13(1):6356
Nature communications 2022 Oct 26;13(1):6356
In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides.
Li L, Yang S, Chen D, Wu Z, Zhang M, Yang F, Qin L, Zhou X
Molecules (Basel, Switzerland) 2022 Nov 29;27(23)
Molecules (Basel, Switzerland) 2022 Nov 29;27(23)
Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment.
Tripodi L, Molinaro D, Fortunato F, Mella C, Cassani B, Torrente Y, Farini A
International journal of molecular sciences 2022 Nov 24;23(23)
International journal of molecular sciences 2022 Nov 24;23(23)
Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice.
Farini A, Tripodi L, Villa C, Napolitano F, Strati F, Molinaro D, Facciotti F, Cassani B, Torrente Y
Cell death & disease 2022 Nov 19;13(11):975
Cell death & disease 2022 Nov 19;13(11):975
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Chen WF, Shih YH, Liu HC, Cheng CI, Chang CI, Chen CY, Lin IP, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly.
Li L, Yang W, Ma X, Wu J, Qin X, Cao X, Zhou J, Jin L, He J, Zheng H, Liu X, Li D, Shang Y
Journal of virology 2022 May 25;96(10):e0030922
Journal of virology 2022 May 25;96(10):e0030922
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Dong S, Kong N, Zhang Y, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2022 May 25;96(10):e0007022
Journal of virology 2022 May 25;96(10):e0007022
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Hu S, Luo L, Bian X, Liu RH, Zhao S, Chen Y, Sun K, Jiang J, Liu Z, Zeng L
Journal of agricultural and food chemistry 2022 May 11;70(18):5610-5623
Journal of agricultural and food chemistry 2022 May 11;70(18):5610-5623
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Xiong T, Zheng X, Zhang K, Wu H, Dong Y, Zhou F, Cheng B, Li L, Xu W, Su J, Huang J, Jiang Z, Li B, Zhang B, Lv G, Chen S
Journal of ethnopharmacology 2022 May 10;289:115001
Journal of ethnopharmacology 2022 May 10;289:115001
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Mao J, Zhan H, Meng F, Wang G, Huang D, Liao Z, Chen M
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
Zheng X, Mi T, Wang R, Zhang Z, Li W, Zhao J, Yang P, Xia H, Mao Q
Glia 2022 Jul;70(7):1317-1336
Glia 2022 Jul;70(7):1317-1336
Effects of Artemisinin on Escherichia coli-Induced Mastitis in Bovine Mammary Epithelial Cells and Mice.
Li Z, Hu J, Wang X, Du Y, Yin J, Gao J, Han B, Cui S, Liu Y, Liu J
Veterinary sciences 2022 Jul 26;9(8)
Veterinary sciences 2022 Jul 26;9(8)
The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf.
Feng R, Adeniran SO, Huang F, Li Y, Ma M, Zheng P, Zhang G
Theriogenology 2022 Feb;179:103-116
Theriogenology 2022 Feb;179:103-116
A positive feed-forward loop between Fusobacterium nucleatum and ethanol metabolism reprogramming drives laryngeal cancer progression and metastasis.
Hsueh CY, Huang Q, Gong H, Shen Y, Sun J, Lau HC, Zhang D, Tang D, Wu C, Guo Y, Huang H, Cao P, Tao L, Zhang M, Zhou L
iScience 2022 Feb 18;25(2):103829
iScience 2022 Feb 18;25(2):103829
Quercetin ameliorates memory impairment by inhibiting abnormal microglial activation in a mouse model of paradoxical sleep deprivation.
Zhang Y, Xie Y, Cheng Z, Xi K, Huang X, Kuang F, Wang W, Liu T, Guo B, Wu S
Biochemical and biophysical research communications 2022 Dec 3;632:10-16
Biochemical and biophysical research communications 2022 Dec 3;632:10-16
Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats.
Li J, Liu X, Wu Y, Ji W, Tian Q, Li S
Biochemical and biophysical research communications 2022 Dec 17;634:75-82
Biochemical and biophysical research communications 2022 Dec 17;634:75-82
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
Ding Q, Chen K, Liu X, Ding C, Zhao Y, Sun S, Zhang Y, Zhang J, Liu S, Liu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
Clostridium butyricum inhibits the progression of colorectal cancer and alleviates intestinal inflammation via the myeloid differentiation factor 88 (MyD88)-nuclear factor-kappa B (NF-κB) signaling pathway.
Zhou M, Yuan W, Yang B, Pei W, Ma J, Feng Q
Annals of translational medicine 2022 Apr;10(8):478
Annals of translational medicine 2022 Apr;10(8):478
Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway.
Su HY, Tsai YC, Tsai HP, Lin CL
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Gut Microbiota Disorders Promote Inflammation and Aggravate Spinal Cord Injury Through the TLR4/MyD88 Signaling Pathway.
Rong Z, Huang Y, Cai H, Chen M, Wang H, Liu G, Zhang Z, Wu J
Frontiers in nutrition 2021;8:702659
Frontiers in nutrition 2021;8:702659
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M, Wang Y, Hong D, Li F, Wang B, Chen T, Fang X
Oxidative medicine and cellular longevity 2021;2021:9424582
Oxidative medicine and cellular longevity 2021;2021:9424582
EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway.
Wang P, Tian H, Zhang Z, Wang Z
Stem cells international 2021;2021:7625134
Stem cells international 2021;2021:7625134
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38-/- Sepsis Mice.
Zhang H, Du Y, Guo Y, Wang Z, Li H, Lv Z, Zeng L, Chen Y, Xie Z, Li R
Journal of immunology research 2021;2021:6687555
Journal of immunology research 2021;2021:6687555
Zanthoxylum bungeanum Seed Oil Attenuates LPS-Induced BEAS-2B Cell Activation and Inflammation by Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway.
Hou J, Wang J, Meng J, Zhang X, Niu Y, Gao J, Bai Y, Zhou J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2073296
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2073296
Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model.
Fang X, Yue M, Wei J, Wang Y, Hong D, Wang B, Zhou X, Chen T
Frontiers in immunology 2021;12:792746
Frontiers in immunology 2021;12:792746
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Xu Y, Xie L, Tang J, He X, Zhang Z, Chen Y, Zhou J, Gan B, Peng W
Frontiers in microbiology 2021;12:742033
Frontiers in microbiology 2021;12:742033
Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis.
Qu Y, Li X, Xu F, Zhao S, Wu X, Wang Y, Xie J
Frontiers in immunology 2021;12:679897
Frontiers in immunology 2021;12:679897
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway.
Xie X, Zhao J, Gao W, Chen J, Hu B, Cai X, Zheng Y
Theranostics 2021;11(7):3213-3228
Theranostics 2021;11(7):3213-3228
Intestinal Microbiota Play an Important Role in the Treatment of Type I Diabetes in Mice With BefA Protein.
Qin Q, Chen Y, Li Y, Wei J, Zhou X, Le F, Hu H, Chen T
Frontiers in cellular and infection microbiology 2021;11:719542
Frontiers in cellular and infection microbiology 2021;11:719542
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429
Annals of translational medicine 2021 Sep;9(18):1429
Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.
Li LC, Ning DS, Fu YX, Pan ZH
Fitoterapia 2021 Sep;153:104949
Fitoterapia 2021 Sep;153:104949
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell-cell interactions.
Dong L, Liu Y, Wang D, Zhu K, Zou Z, Zhang A
Environmental toxicology 2021 Oct;36(10):2073-2092
Environmental toxicology 2021 Oct;36(10):2073-2092
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
Du L, Qi R, Wang J, Liu Z, Wu Z
International journal of molecular sciences 2021 Nov 18;22(22)
International journal of molecular sciences 2021 Nov 18;22(22)
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
Hu S, Chen Y, Zhao S, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats.
Yue Y, Liu X, Li Y, Xia B, Yu W
Oral diseases 2021 May;27(4):1012-1021
Oral diseases 2021 May;27(4):1012-1021
The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy.
Zheng Z, Liang P, Hou B, Lu X, Ma Q, Yu X, Han S, Peng B, Chen T, Liu W, Yin J, He X
Journal of neuroinflammation 2021 May 11;18(1):112
Journal of neuroinflammation 2021 May 11;18(1):112
Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats.
Wang XY, Ma HJ, Xue M, Sun YL, Ren A, Li MQ, Huang ZH, Huang C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111215
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111215
Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets.
Fu J, Wang T, Xiao X, Cheng Y, Wang F, Jin M, Wang Y, Zong X
Cells 2021 Mar 2;10(3)
Cells 2021 Mar 2;10(3)
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, Wang F, Jin M, Min J, Wang F, Wang Y
Nucleic acids research 2021 Jun 4;49(10):5537-5552
Nucleic acids research 2021 Jun 4;49(10):5537-5552
Dietary Ursolic Acid Prevents Alcohol-Induced Liver Injury via Gut-Liver Axis Homeostasis Modulation: The Key Role of Microbiome Manipulation.
Yan X, Ren X, Liu X, Wang Y, Ma J, Song R, Wang X, Dong Y, Fan Q, Wei J, Yu A, She G
Journal of agricultural and food chemistry 2021 Jun 30;69(25):7074-7083
Journal of agricultural and food chemistry 2021 Jun 30;69(25):7074-7083
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
Zhao J, Wan S, Sun N, Sun P, Sun Y, Khan A, Guo J, Zheng X, Fan K, Yin W, Li H
Veterinary research 2021 Jun 23;52(1):93
Veterinary research 2021 Jun 23;52(1):93
Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.
Chen Z, Zhang L, Yang J, Zheng L, Hu F, Duan S, Nandakumar KS, Liu S, Yin H, Cheng K
Journal of medicinal chemistry 2021 Jun 10;64(11):7371-7389
Journal of medicinal chemistry 2021 Jun 10;64(11):7371-7389
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Fang M, Wan W, Li Q, Wan W, Long Y, Liu H, Yang X
Life sciences 2021 Jul 15;277:119567
Life sciences 2021 Jul 15;277:119567
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY
Inflammopharmacology 2021 Aug;29(4):1187-1200
Inflammopharmacology 2021 Aug;29(4):1187-1200
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Tian S, Liao L, Zhou Q, Huang X, Zheng P, Guo Y, Deng T, Tian X
Oncology letters 2021 Apr;21(4):286
Oncology letters 2021 Apr;21(4):286
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, Duan Y, Li K, Liu K, Peng C
BioMed research international 2020;2020:1860637
BioMed research international 2020;2020:1860637
Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain.
He M, Qian K, Zhang Y, Huang XF, Deng C, Zhang B, Gao G, Li J, Xie H, Sun T
Frontiers in neuroscience 2020;14:589650
Frontiers in neuroscience 2020;14:589650
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Wei A, Xiao H, Xu G, Yu X, Guo J, Jing Z, Shi S, Song Y
Frontiers in pharmacology 2020;11:762
Frontiers in pharmacology 2020;11:762
Astragaloside IV Improves High-Fat Diet-Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway.
Liu YL, Zhang QZ, Wang YR, Fu LN, Han JS, Zhang J, Wang BM
Frontiers in pharmacology 2020;11:605064
Frontiers in pharmacology 2020;11:605064
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.
Farini A, Villa C, Di Silvestre D, Bella P, Tripodi L, Rossi R, Sitzia C, Gatti S, Mauri P, Torrente Y
Frontiers in physiology 2020;11:403
Frontiers in physiology 2020;11:403
Pyrroloquinoline Quinone Alleviates Jejunal Mucosal Barrier Function Damage and Regulates Colonic Microbiota in Piglets Challenged With Enterotoxigenic Escherichia coli.
Huang C, Ming D, Wang W, Wang Z, Hu Y, Ma X, Wang F
Frontiers in microbiology 2020;11:1754
Frontiers in microbiology 2020;11:1754
Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.
Lv W, Graves DT, He L, Shi Y, Deng X, Zhao Y, Dong X, Ren Y, Liu X, Xiao E, Zhang Y
Theranostics 2020;10(14):6500-6516
Theranostics 2020;10(14):6500-6516
Tumor-derived HMGB1 induces CD62L(dim) neutrophil polarization and promotes lung metastasis in triple-negative breast cancer.
Wang Z, Yang C, Li L, Jin X, Zhang Z, Zheng H, Pan J, Shi L, Jiang Z, Su K, Li B, Shao X, Qiu F, Yan J, Huang J
Oncogenesis 2020 Sep 17;9(9):82
Oncogenesis 2020 Sep 17;9(9):82
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935
Life sciences 2020 Sep 1;256:117935
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
Targeting Toll-like receptor 4 with CLI-095 (TAK-242) enhances the antimetastatic effect of the estrogen receptor antagonist fulvestrant on non-small cell lung cancer.
Fan S, Liao Y, Qiu W, Li L, Li D, Cao X, Ai B
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Nov;22(11):2074-2086
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Nov;22(11):2074-2086
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Wang X, Zhou J, Yang J, Wang S, Yang L
Experimental and therapeutic medicine 2020 Nov;20(5):115
Experimental and therapeutic medicine 2020 Nov;20(5):115
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis.
Lin M, Huang J, Chen WC, Fan ZN, Qin X
Iranian journal of immunology : IJI 2020 Mar;17(1):52-63
Iranian journal of immunology : IJI 2020 Mar;17(1):52-63
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model.
Wei A, Song Y, Ni T, Xiao H, Wan Y, Ren X, Li H, Xu G
Life sciences 2020 Aug 1;254:117735
Life sciences 2020 Aug 1;254:117735
Estrogen promotes the metastasis of non‑small cell lung cancer via estrogen receptor β by upregulation of Toll‑like receptor 4 and activation of the myd88/NF‑κB/MMP2 pathway.
Fan S, Liao Y, Qiu W, Huang Q, Xiao H, Liu C, Li D, Cao X, Li L, Liang H, Ai B, Zhou S
Oncology reports 2020 Apr 2;
Oncology reports 2020 Apr 2;
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L
Oxidative medicine and cellular longevity 2019;2019:7850324
Oxidative medicine and cellular longevity 2019;2019:7850324
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:6565283
Oxidative medicine and cellular longevity 2019;2019:6565283
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X, Fu W
Oxidative medicine and cellular longevity 2019;2019:3765898
Oxidative medicine and cellular longevity 2019;2019:3765898
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, Yang Y, Liu B
International journal of medical sciences 2019;16(12):1593-1603
International journal of medical sciences 2019;16(12):1593-1603
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Xu W, Hu GQ, Da Costa C, Tang JH, Li QR, Du L, Pan YW, Lv SQ
OncoTargets and therapy 2019;12:3467-3480
OncoTargets and therapy 2019;12:3467-3480
Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation.
Wang D, Dong X, Wang B, Liu Y, Li S
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10079-10088
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10079-10088
Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop.
Liang S, Wang ZG, Zhang ZZ, Chen K, Lv ZT, Wang YT, Cheng P, Sun K, Yang Q, Chen AM
Aging 2019 Oct 11;11(19):8664-8680
Aging 2019 Oct 11;11(19):8664-8680
Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.
Bi J, Wang W, Du J, Chen K, Cheng K
European journal of medicinal chemistry 2019 Oct 1;179:233-245
European journal of medicinal chemistry 2019 Oct 1;179:233-245
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages.
Deng F, He S, Cui S, Shi Y, Tan Y, Li Z, Huang C, Liu D, Zhi F, Peng L
Journal of Crohn's & colitis 2019 Mar 30;13(4):482-494
Journal of Crohn's & colitis 2019 Mar 30;13(4):482-494
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Cheng Z, Zhang M, Ling C, Zhu Y, Ren H, Hong C, Qin J, Liu T, Wang J
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Molecules (Basel, Switzerland) 2019 Mar 20;24(6)
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.
Jin YH, Li ZT, Chen H, Jiang XQ, Zhang YY, Wu F
European review for medical and pharmacological sciences 2019 Jun;23(11):5020-5025
European review for medical and pharmacological sciences 2019 Jun;23(11):5020-5025
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Sun P, Sun N, Yin W, Sun Y, Fan K, Guo J, Khan A, He Y, Li H
Veterinary research 2019 Jul 12;50(1):53
Veterinary research 2019 Jul 12;50(1):53
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Xu B, Zang SC, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Brain, behavior, and immunity 2019 Feb;76:223-235
Brain, behavior, and immunity 2019 Feb;76:223-235
Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.
Wang Y, Xu X, Hu P, Jia N, Ji S, Yuan H
World neurosurgery 2019 Dec;132:e529-e534
World neurosurgery 2019 Dec;132:e529-e534
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Hu Y, Li Q, Pan Y, Xu L
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105.
Yang Y, Yang J, Liu XW, Ding JW, Li S, Guo X, Yang CJ, Fan ZX, Wang HB, Li Q, Wang HM, Yang J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(3):1049-1063
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(3):1049-1063
Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD.
He S, Guo W, Deng F, Chen K, Jiang Y, Dong M, Peng L, Chen X
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):217-228
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):217-228
Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
Liu M, Li C, Zhao GQ, Lin J, Che CY, Xu Q, Wang Q, Xu R, Niu YW
International journal of ophthalmology 2018;11(4):548-552
International journal of ophthalmology 2018;11(4):548-552
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.
Zhang F, Dong H, Lv T, Jin K, Jin Y, Zhang X, Jiang J
Journal of neuroinflammation 2018 Sep 20;15(1):273
Journal of neuroinflammation 2018 Sep 20;15(1):273
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thrombosis research 2018 Nov;171:45-54
Thrombosis research 2018 Nov;171:45-54
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Chen S, Lyu C, Zhou J, Huang S, Zhang Y, Liu G, Liu K, Chen D, Hu Y, Zhou L, Gu Y
Neuroscience letters 2018 Nov 1;686:33-40
Neuroscience letters 2018 Nov 1;686:33-40
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, Li X, Wang J
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Zhao X, Yin L, Fang L, Xu L, Sun P, Xu M, Liu K, Peng J
International immunopharmacology 2018 Dec;65:458-469
International immunopharmacology 2018 Dec;65:458-469
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Cui Y, Wang Y, Zhao D, Feng X, Zhang L, Liu C
Cell biology international 2018 Dec;42(12):1632-1642
Cell biology international 2018 Dec;42(12):1632-1642
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
Zhou S, Wang G, Zhang W
Experimental and therapeutic medicine 2018 Apr;15(4):3376-3384
Experimental and therapeutic medicine 2018 Apr;15(4):3376-3384
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, Shang D
Frontiers in immunology 2017;8:1488
Frontiers in immunology 2017;8:1488
DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.
Jing H, Zhou Y, Fang L, Ding Z, Wang D, Ke W, Chen H, Xiao S
Frontiers in immunology 2017;8:1365
Frontiers in immunology 2017;8:1365
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673
Mediators of inflammation 2017;2017:9891673
Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage.
Huang XP, Peng JH, Pang JW, Tian XC, Li XS, Wu Y, Li Y, Jiang Y, Sun XC
Frontiers in molecular neuroscience 2017;10:398
Frontiers in molecular neuroscience 2017;10:398
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Wu J, Zhang H, Hu B, Yang L, Wang P, Wang F, Meng X
European journal of pharmacology 2016 Jun 5;780:106-14
European journal of pharmacology 2016 Jun 5;780:106-14
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141
International immunopharmacology 2016 Jul;36:132-141
Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway.
Wang Y, Chen G, Yu X, Li Y, Zhang L, He Z, Zhang N, Yang X, Zhao Y, Li N, Qiu H
Inflammation 2016 Aug;39(4):1503-13
Inflammation 2016 Aug;39(4):1503-13
Neuroprotective effects of rhynchophylline against ischemic brain injury via regulation of the Akt/mTOR and TLRs signaling pathways.
Huang H, Zhong R, Xia Z, Song J, Feng L
Molecules (Basel, Switzerland) 2014 Jul 30;19(8):11196-210
Molecules (Basel, Switzerland) 2014 Jul 30;19(8):11196-210
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