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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [112]
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- Product number
- 67969-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- MYD88 antibody
- Antibody type
- Monoclonal
- Description
- MYD88 antibody (Cat. #67969-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, rabbit, pig and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine, Rabbit
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2E10D3
- Vial size
- 20ul, 150ul
Submitted references Therapeutic effect and mechanism of different doses of aspirin on preterm delivery in pregnant mice.
Fire Needling Acupuncture Reduces Neutrophil Extracellular Traps (NETs) Formation and Inhibits TLR4/NF-κB/LCN2 Pathway in Psoriasis-Like Skin Lesions.
Isoimperatorin alleviates fungal keratitis by regulating NF-κB pathway and macrophage immune response.
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
Modulation of immune cell differentiation by Prunella vulgaris L. essential oil in pulmonary sarcoidosis treatment.
Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis.
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice.
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets.
Chrysanthemum 3,5-O-dicaffeoylquinic acid ameliorates mouse alcoholic liver injury by suppressing the TLR-4/NF-κB pathway and restoring glycerophospholipid homeostasis.
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Febuxostat alleviates gout-associated hyperuricemia and inflammation by downregulating IL1A to modulate TLR2/TLR4/NF-κB signaling pathway.
Astaxanthin protects against acute lung injury via dual modulation of Ca(2+)/CaMKIIα/NLRP3 and TLR2/MyD88/NLRP3 pathways.
Bawei Chenxiang Pills Exert Anti-Myocardial Ischemia Effect by Inhibiting Inflammation Through the TLR4/NF-κB/NLRP3 Signaling Pathway.
Comparative Analysis of Polysaccharides from Chicory Roots and Aerial Parts Reveals Comparable Cytoprotective Effects Associated with MAPK/NF-κB Signaling.
SIRT4 knockout exacerbates lung injury in septic mice by activating TLR4/MYD88/NFκB pathway.
Houttuynia cordata Polysaccharide Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Macrophage Polarization via Inhibiting the TLR4/NF-κB Signaling Pathway.
Potential of quercitrin in psoriasis intervention: Dual regulation of the oxidative stress-NF-κB axis and gut microbiota homeostasis.
Dual-functional self-assembled nanosystems with enhanced protease resistance: Promoting bacterial aggregation and immune activation for multidrug-resistant bacterial infection.
Cornus officinalis Siebold & Zucc. ethanol extract alleviates primary dysmenorrhea via anti-inflammatory and spasmolytic effects: network pharmacology and experimental verification.
Exploring possible mechanisms of antiviral effect of Shufeng Jiedu Capsule on viral pneumonia: A comprehensive analysis.
Gut microbiota: A critical regulator of oxaliplatin-induced peripheral neurotoxicity development.
Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis.
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.
Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling.
Furongtongmai capsule alleviates neuroinflammation by downregulating the TLR4/MyD88/JNK pathway to promote the recovery of peripheral nerve compression.
HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction.
Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota.
7-Methoxyflavanone Alleviates LPS-Induced Acute Lung Injury by Suppressing TLR4/NF-κB p65 and ROS/Txnip/NLRP3 Signaling.
Alfalfa Polysaccharide Alleviates Colitis by Regulating Intestinal Microbiota and the Intestinal Barrier Against the TLR4/MyD88/NF-κB Pathway.
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages.
The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.
Inhibition of Galectin-3 by ADSC-derived exosomes after cavernous nerve injury ameliorates erectile dysfunction by modulating oxidative stress and inflammatory profibrotic cascades.
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
The study of the therapeutic effect and preliminary mechanism of EGCG on recurrent aphthous ulcer.
Design and synthesis of novel diclofenac-based quinazoline derivatives enhancing cisplatin and radiation impacts via MyD88 and COX-2/PGE2 modulation.
Asiaticoside alleviates migraine-induced cognitive impairment via TLR4-Mediated apoptosis regulation.
The important role of TLR2/MyD88/JNK in regulating the pathogenesis and inflammation induced by pseudorabies virus in mice.
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Ketogenic diet attenuates neuroinflammation and restores hippocampal neurogenesis to improve CUMS induced depression-like behavior in mice.
Extracellular HSP70 facilitated β-glucan induced trained immunity in macrophages to suppress sepsis via TLR2-NF-κB axis.
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation.
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.
Respiratory Syncytial Virus Infection Disrupts Airway Epithelial Barriers via IL-33/ST2/MyD88 Signaling Axis.
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation.
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling.
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats.
Sodium butyrate attenuates microglia-mediated neuroinflammation by modulating the TLR4/MyD88/NF-κB pathway and microbiome-gut-brain axis in cardiac arrest mice.
Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.
Dietary chlorogenic acid enhances intestinal barrier function and modulates cecal microbiota in laying hens under H(2)O(2)-induced oxidative stress.
Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway.
Vitamin D(3) attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization.
Nanoassemblies loaded with low-dose paclitaxel can enhance the response of lung cancer immunotherapy by activating dendritic cells.
Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway.
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.
Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis.
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Rice bran active peptide (RBAP) inhibited macrophage differentiation to foam cell and atherosclerosis in mice via regulating cholesterol efflux.
Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway.
GATA2 downregulation contributes to pro-inflammatory phenotype and defective phagocytosis of pulmonary macrophages in chronic obstructive pulmonary disease.
Modulation of choline and lactate metabolism by basic fibroblast growth factor mitigates neuroinflammation in type 2 diabetes: Insights from (1)H-NMR metabolomics analysis.
Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Specific molecular weight of Lycium barbarum polysaccharide for robust breast cancer regression by repolarizing tumor-associated macrophages.
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Wolbachia mediates crosstalk between miRNA and Toll pathways to enhance resistance to dengue virus in Aedes aegypti.
MyD88 Inhibition Attenuates Cerebral Ischemia-reperfusion Injury by Regulating the Inflammatory Response and Reducing Blood-brain Barrier Damage.
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis.
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis.
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Guizhi Shaoyao Zhimu Decoction ameliorates gouty arthritis in rats via altering gut microbiota and improving metabolic profile.
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Association of IL-9 Cytokines with Hepatic Injury in Echinococcus granulosus Infection.
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2.
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Escherichia coli Promotes Endothelial to Mesenchymal Transformation of Liver Sinusoidal Endothelial Cells and Exacerbates Nonalcoholic Fatty Liver Disease Via Its Flagellin.
Protective effects of Scutellariae Radix Carbonisata-derived carbon dots on blood-heat and hemorrhage rats.
TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea.
Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury.
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p.
IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders.
Region-resolved multi-omics of the mouse eye.
Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy.
In vitro validation: GLY alleviates UV-induced corneal epithelial damage through the HMGB1-TLR/MyD88-NF-κB signaling pathway.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway.
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
Qu X, Wu X, Pang X, Fang Y
PloS one 2026;21(3):e0344041
PloS one 2026;21(3):e0344041
Fire Needling Acupuncture Reduces Neutrophil Extracellular Traps (NETs) Formation and Inhibits TLR4/NF-κB/LCN2 Pathway in Psoriasis-Like Skin Lesions.
Wang Q, Wei J, Wang X, Yuan F, Sun J
Journal of inflammation research 2026;19:569462
Journal of inflammation research 2026;19:569462
Isoimperatorin alleviates fungal keratitis by regulating NF-κB pathway and macrophage immune response.
Song S, Xu H, Liu M, Xu Q, Wang L, Wang F, Wan X, Sun X, Che C
Frontiers in immunology 2026;17:1676397
Frontiers in immunology 2026;17:1676397
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
Hu N, Gao Y, Fan R, Xue Y, Fang S, Wu S, Luo T, Hu L, Zhang D, Zheng L
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
Modulation of immune cell differentiation by Prunella vulgaris L. essential oil in pulmonary sarcoidosis treatment.
Mao Z, Yang X, Liu Y, Huan Y, Gao Y, Zhang J, Lin X, Tian S, Song Y, Miao M
Fitoterapia 2026 Mar;189:107049
Fitoterapia 2026 Mar;189:107049
Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis.
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Clinical and translational medicine 2026 Mar;16(3):e70637
Clinical and translational medicine 2026 Mar;16(3):e70637
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
Yang H, Li Y, Xiao Z, Kuang M
Molecular carcinogenesis 2026 Jun;65(6):699-714
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Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice.
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Journal of ethnopharmacology 2026 Jun 28;365:121458
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Journal of ethnopharmacology 2026 Jul 15;366:121648
Journal of ethnopharmacology 2026 Jul 15;366:121648
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Qu Z, Ding Y, Zhang L, Sun J, Wang T, Zhuang C
Free radical research 2026 Jan;60(1):1-15
Free radical research 2026 Jan;60(1):1-15
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Sun X, Zhang T, Zhu W, Jiang X, Wang S, Zhao Y, Bian X
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets.
Zhang L, Wu Z, Shen H, Meng Y, Li H, Cai R, Tang D, Kang M, Yin Y, Tan B, Wang J
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Chrysanthemum 3,5-O-dicaffeoylquinic acid ameliorates mouse alcoholic liver injury by suppressing the TLR-4/NF-κB pathway and restoring glycerophospholipid homeostasis.
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Food & function 2026 Jan 26;17(2):846-860
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A
NPJ science of food 2026 Jan 23;10(1):73
NPJ science of food 2026 Jan 23;10(1):73
Febuxostat alleviates gout-associated hyperuricemia and inflammation by downregulating IL1A to modulate TLR2/TLR4/NF-κB signaling pathway.
Hu M, Zhou Y, Zhang Y, Pan F, Liu M
International immunopharmacology 2026 Jan 1;168(Pt 2):115935
International immunopharmacology 2026 Jan 1;168(Pt 2):115935
Astaxanthin protects against acute lung injury via dual modulation of Ca(2+)/CaMKIIα/NLRP3 and TLR2/MyD88/NLRP3 pathways.
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Bawei Chenxiang Pills Exert Anti-Myocardial Ischemia Effect by Inhibiting Inflammation Through the TLR4/NF-κB/NLRP3 Signaling Pathway.
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Comparative Analysis of Polysaccharides from Chicory Roots and Aerial Parts Reveals Comparable Cytoprotective Effects Associated with MAPK/NF-κB Signaling.
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International journal of molecular sciences 2026 Feb 28;27(5)
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SIRT4 knockout exacerbates lung injury in septic mice by activating TLR4/MYD88/NFκB pathway.
Chang S, Sun W, Liao K, Luo S, He A, Zhang G, Li N
Free radical biology & medicine 2026 Feb 16;244:229-237
Free radical biology & medicine 2026 Feb 16;244:229-237
Houttuynia cordata Polysaccharide Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Macrophage Polarization via Inhibiting the TLR4/NF-κB Signaling Pathway.
Yu B, He D, Chen Z, Zhou Y, Zhou J, Wang T, Qiu Q, Chen Z, Ma X, Zhu J, Zheng S, Qiu T
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Potential of quercitrin in psoriasis intervention: Dual regulation of the oxidative stress-NF-κB axis and gut microbiota homeostasis.
Guo D, Wang R, Liu S, Liu W, Wang X
Cellular signalling 2026 Aug;144:112504
Cellular signalling 2026 Aug;144:112504
Dual-functional self-assembled nanosystems with enhanced protease resistance: Promoting bacterial aggregation and immune activation for multidrug-resistant bacterial infection.
Gao N, Bian Y, Wang S, Bai P, Fang C, Sun J, Li Y, Dong N, Shan A, Wang J
Asian journal of pharmaceutical sciences 2026 Apr;21(2):101145
Asian journal of pharmaceutical sciences 2026 Apr;21(2):101145
Cornus officinalis Siebold & Zucc. ethanol extract alleviates primary dysmenorrhea via anti-inflammatory and spasmolytic effects: network pharmacology and experimental verification.
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Fitoterapia 2026 Apr;190:107176
Fitoterapia 2026 Apr;190:107176
Exploring possible mechanisms of antiviral effect of Shufeng Jiedu Capsule on viral pneumonia: A comprehensive analysis.
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Chinese herbal medicines 2026 Apr;18(2):282-293
Chinese herbal medicines 2026 Apr;18(2):282-293
Gut microbiota: A critical regulator of oxaliplatin-induced peripheral neurotoxicity development.
Liu Z, Zhang T, Wang S, Yin H, Shao X, Gao L, Lu X
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Neurotoxicology 2026 Apr 21;114:103460
Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis.
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PloS one 2025;20(11):e0337061
PloS one 2025;20(11):e0337061
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
Yang Z, Kao X, Zhang L, Huang N, Chen J, He M
Drug design, development and therapy 2025;19:349-368
Drug design, development and therapy 2025;19:349-368
DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.
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Frontiers in immunology 2025;16:1656069
Frontiers in immunology 2025;16:1656069
Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling.
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Brain research bulletin 2025 Sep;229:111462
Brain research bulletin 2025 Sep;229:111462
Furongtongmai capsule alleviates neuroinflammation by downregulating the TLR4/MyD88/JNK pathway to promote the recovery of peripheral nerve compression.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157082
HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156976
Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota.
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Food science & nutrition 2025 Sep;13(9):e70989
7-Methoxyflavanone Alleviates LPS-Induced Acute Lung Injury by Suppressing TLR4/NF-κB p65 and ROS/Txnip/NLRP3 Signaling.
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Biology 2025 Sep 2;14(9)
Alfalfa Polysaccharide Alleviates Colitis by Regulating Intestinal Microbiota and the Intestinal Barrier Against the TLR4/MyD88/NF-κB Pathway.
La S, Abaidullah M, Li H, Cui Y, Liu B, Shi Y
Nutrients 2025 Sep 19;17(18)
Nutrients 2025 Sep 19;17(18)
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages.
Gu D, Hu L, Yang K, Yuan W, Shan D, Gao J, Li J, Gimple RC, Dixit D, Zhu Z, Li D, Wu Q, Shi Z, Wang Y, Zhao N, Yang K, Shao J, Lin F, Wang Q, Jin G, Chen Y, Qian X, Hu Z, Li C, Zhang N, You Y, Liu J, Zhang Q, Zhang J, Rich JN, Wang X
Developmental cell 2025 Oct 6;60(19):2558-2575.e6
Developmental cell 2025 Oct 6;60(19):2558-2575.e6
The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.
Wang W, Wu H, Li J, Chen Z, Liu J, Xu E, Hassanin AA, Rahman SU, Chen L, Zheng R
Protoplasma 2025 Nov;262(6):1451-1468
Protoplasma 2025 Nov;262(6):1451-1468
Inhibition of Galectin-3 by ADSC-derived exosomes after cavernous nerve injury ameliorates erectile dysfunction by modulating oxidative stress and inflammatory profibrotic cascades.
Li R, Wang G, Feng C, Diao T, Liu S, Fu Q
Stem cell research & therapy 2025 Nov 7;16(1):627
Stem cell research & therapy 2025 Nov 7;16(1):627
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
Leng J, Cao Z, Li L, Hu D, Luo Y, Tu B, Cao X, Tao R, Jiang Y, Tie H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
The study of the therapeutic effect and preliminary mechanism of EGCG on recurrent aphthous ulcer.
You X, Shi J, Ren Z, Wang L, Zhao W
Scientific reports 2025 Nov 28;15(1):45634
Scientific reports 2025 Nov 28;15(1):45634
Design and synthesis of novel diclofenac-based quinazoline derivatives enhancing cisplatin and radiation impacts via MyD88 and COX-2/PGE2 modulation.
Ghorab MM, El-Gazzar MGM, Soliman AM, Abdou FY, El-Sabbagh WA
European journal of medicinal chemistry 2025 Nov 15;298:117997
European journal of medicinal chemistry 2025 Nov 15;298:117997
Asiaticoside alleviates migraine-induced cognitive impairment via TLR4-Mediated apoptosis regulation.
Jiang W, Feng XM, Yu P, Zhang LX, Cai MT, Qu K, Yang Y, Dong M
European journal of pharmacology 2025 Nov 15;1007:178204
European journal of pharmacology 2025 Nov 15;1007:178204
The important role of TLR2/MyD88/JNK in regulating the pathogenesis and inflammation induced by pseudorabies virus in mice.
Niu J, Li G, Liu Y, Wan C, Li Y, Dai Y, Hu H, Peng L, Fang R, Ye C
Veterinary microbiology 2025 May;304:110496
Veterinary microbiology 2025 May;304:110496
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Zhou M, Yang C, Liu YW, Yang T, Sun B, Li B, Zheng J, Dai S, Yang Z, Wang X
Biomarker research 2025 May 9;13(1):72
Biomarker research 2025 May 9;13(1):72
Ketogenic diet attenuates neuroinflammation and restores hippocampal neurogenesis to improve CUMS induced depression-like behavior in mice.
Liang J, Zhang J, Sun J, Liang Q, Zhan Y, Yang Z, Zhang Y, Jin L, Hu C, Zhao YT
Food & function 2025 May 6;16(9):3408-3422
Food & function 2025 May 6;16(9):3408-3422
Extracellular HSP70 facilitated β-glucan induced trained immunity in macrophages to suppress sepsis via TLR2-NF-κB axis.
Qi R, Cheng X, Chen S, Fan J
Cytokine 2025 Mar;187:156861
Cytokine 2025 Mar;187:156861
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation.
Yu L, Luo Q, Rao X, Xiao X, Wang P
Scientific reports 2025 Mar 3;15(1):7410
Scientific reports 2025 Mar 3;15(1):7410
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
Zhang T, Wang Y, Nie X, Chen X, Jin Y, Sun L, Yang R, Wang J, Xu W, Song T, Xie W, Chen X, Li C, Zhou J, Wu S, Li Y, Li T
Cell reports 2025 Mar 25;44(3):115397
Cell reports 2025 Mar 25;44(3):115397
GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.
Zhu J, Zhou T, Chen G, Gao H, Chen X, Tuohetali A, Song Y, Pang D, Aimulajiang K
Veterinary research 2025 Mar 11;56(1):55
Veterinary research 2025 Mar 11;56(1):55
Respiratory Syncytial Virus Infection Disrupts Airway Epithelial Barriers via IL-33/ST2/MyD88 Signaling Axis.
Miao Q, Yu R, Shi F, Li K, Du X, Gao Y, Li Y, Cui Y, Chen Y, Liu J, Lv Z, Yuan J, Corrigan CJ, Ying S, Wang W
Journal of medical virology 2025 Jun;97(6):e70432
Journal of medical virology 2025 Jun;97(6):e70432
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Ding Y, Zhang L, Zhao W, Wang T, Shi Y, Zhuang C, Qu Z
Molecular nutrition & food research 2025 Jul;69(13):e70103
Molecular nutrition & food research 2025 Jul;69(13):e70103
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Wang H, Zhang C, He J, He Z, Yan S, Zhang Y, Huang S, Yan Y, Chen Y, Xian Z, Hu R, Wang Y, Xiao W, Wang M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation.
Sun D, Wang W, Fan Q, Wang X, Xu X, Jiang W, Zhao L, Li H, Fu Z, Zhao L, Jiao H
Nutrients 2025 Jan 29;17(3)
Nutrients 2025 Jan 29;17(3)
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling.
Chen Z, Ruan F, Wu D, Yu X, Jiang Y, Bao W, Wen H, Hu J, Bi H, Chen L, Le K
Inflammopharmacology 2025 Feb;33(2):865-883
Inflammopharmacology 2025 Feb;33(2):865-883
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
Sharma P, Naqvi RA, Borase H, Kapoor D, Valverde A, Capistrano K, Yadavalli T, Naqvi AR, Shukla D
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats.
Jiang Y, Yang J, Wei M, Shou J, Shen S, Yu Z, Zhang Z, Cai J, Lyu Y, Yang D, Han Y, Zhu J, Liu Z, Ma D, Xing GG, Li M
Journal of neuroinflammation 2025 Feb 2;22(1):30
Journal of neuroinflammation 2025 Feb 2;22(1):30
Sodium butyrate attenuates microglia-mediated neuroinflammation by modulating the TLR4/MyD88/NF-κB pathway and microbiome-gut-brain axis in cardiac arrest mice.
Sun J, Lu L, Lian Y, Xu S, Zhu Y, Wu Y, Lin Q, Hou J, Li Y, Yu Z
Molecular brain 2025 Feb 17;18(1):13
Molecular brain 2025 Feb 17;18(1):13
Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.
Zhang H, Huang X, Chen R, Lin W, Li L, Peng X, Yang X, Chen X, Guo T, Weng J, Li J, Yuan Q, Tan H, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09998
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e09998
Dietary chlorogenic acid enhances intestinal barrier function and modulates cecal microbiota in laying hens under H(2)O(2)-induced oxidative stress.
Yan M, Sun Y, Zhao H, Feng R, Xie M, Li Y, Zhang Y, Wang Y, Zhang Y, Liu J, Zhu M
Poultry science 2025 Dec;104(12):105922
Poultry science 2025 Dec;104(12):105922
Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway.
Wang Z, Li M, Yan X, Liu Y, Yang P, Liu W, Guan W
International journal of molecular sciences 2025 Dec 6;26(24)
International journal of molecular sciences 2025 Dec 6;26(24)
Vitamin D(3) attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization.
Wang Z, Gao W, Cheng X, Zhang N, Lu W, Li Y, Liu M
Scientific reports 2025 Dec 23;15(1):44345
Scientific reports 2025 Dec 23;15(1):44345
Nanoassemblies loaded with low-dose paclitaxel can enhance the response of lung cancer immunotherapy by activating dendritic cells.
Long J, Li D, Zhao W, Liang G, Huang L, Lei S, Li Y
Translational lung cancer research 2025 Apr 30;14(4):1418-1440
Translational lung cancer research 2025 Apr 30;14(4):1418-1440
Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway.
Wu Y, Chen R, Deng D, Wu W, Wang X
BMC nephrology 2025 Apr 25;26(1):209
BMC nephrology 2025 Apr 25;26(1):209
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Fang X, Jiang XF, Zhang YP, Zhou CL, Dong YJ, Bo-Li, Lv GY, Chen SH
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.
Zhu J, Zhou T, Chen G, Wu Y, Chen X, Song Y, Tuohetali A, Gao H, Pang D, Wen H, Aimulajiang K
Frontiers in immunology 2024;15:1512180
Frontiers in immunology 2024;15:1512180
Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis.
Ma Y, Wei X, Peng J, Wei F, Wen Y, Liu M, Song B, Wang Y, Zhang Y, Peng T
Frontiers in pharmacology 2024;15:1414675
Frontiers in pharmacology 2024;15:1414675
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Li J, Wei L, Hu K, He Y, Gong G, Liu Q, Zhang Y, Zhou K, Guo J, Hua Y, Tang J, Li Y
Theranostics 2024;14(9):3486-3508
Theranostics 2024;14(9):3486-3508
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Yu J, Meng Z, Liu X, Zheng Y, Xue D, Hao C, Wang L
ImmunoTargets and therapy 2024;13:789-803
ImmunoTargets and therapy 2024;13:789-803
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
Zhao HR, Xian QC, Zhang XM, Ma XY, Wang FQ, Wang RS, Liu ZJ, Zhang ZG
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Long L, Dai X, Yao T, Zhang X, Jiang G, Cheng X, Jiang M, He Y, Peng Z, Hu G, Tao L, Meng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Rice bran active peptide (RBAP) inhibited macrophage differentiation to foam cell and atherosclerosis in mice via regulating cholesterol efflux.
Mu J, Lin Q, Chen Y, Wang J, Yu X, Huang F, Liu X, Fang Y, Li Y, Zhu B, Liang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155864
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155864
Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway.
Guan HR, Li B, Zhang ZH, Wu HS, Wang N, Chen XF, Zhou CL, Bian XR, Li L, Xu WF, He XL, Dong YJ, Jiang NH, Su J, Lv GY, Chen SH
Journal of ethnopharmacology 2024 Sep 15;331:118274
Journal of ethnopharmacology 2024 Sep 15;331:118274
GATA2 downregulation contributes to pro-inflammatory phenotype and defective phagocytosis of pulmonary macrophages in chronic obstructive pulmonary disease.
Shen S, Huang Q, Liu L, Zou X, Kang T, Wu J
Aging 2024 Oct 7;16(19):12928-12951
Aging 2024 Oct 7;16(19):12928-12951
Modulation of choline and lactate metabolism by basic fibroblast growth factor mitigates neuroinflammation in type 2 diabetes: Insights from (1)H-NMR metabolomics analysis.
Wu Y, Wang X, Zhang W, Fu J, Jiang K, Shen Y, Li C, Gao H
Neuropharmacology 2024 Oct 1;257:110049
Neuropharmacology 2024 Oct 1;257:110049
Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis.
Zhang H, Wang Z, Li J, Jia Y, Li F
International immunopharmacology 2024 Nov 15;141:112923
International immunopharmacology 2024 Nov 15;141:112923
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Specific molecular weight of Lycium barbarum polysaccharide for robust breast cancer regression by repolarizing tumor-associated macrophages.
Liu MQ, Bao CJ, Liang XF, Ji XY, Zhao LQ, Yao AN, Guo S, Duan JL, Zhao M, Duan JA
International journal of biological macromolecules 2024 Mar;261(Pt 1):129674
International journal of biological macromolecules 2024 Mar;261(Pt 1):129674
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Zhu Y, Fang Y, Wang Y, Han D, Liu J, Tian L, Xu M, Wang Y, Cao F
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
Wolbachia mediates crosstalk between miRNA and Toll pathways to enhance resistance to dengue virus in Aedes aegypti.
She L, Shi M, Cao T, Yuan H, Wang R, Wang W, She Y, Wang C, Zeng Q, Mao W, Zhang Y, Wang Y, Xi Z, Pan X
PLoS pathogens 2024 Jun;20(6):e1012296
PLoS pathogens 2024 Jun;20(6):e1012296
MyD88 Inhibition Attenuates Cerebral Ischemia-reperfusion Injury by Regulating the Inflammatory Response and Reducing Blood-brain Barrier Damage.
Jiang F, Xu C, Fan X, Yang S, Fan W, Li M, Song J, Wei W, Chen H, Zhong D, Li G
Neuroscience 2024 Jun 21;549:121-137
Neuroscience 2024 Jun 21;549:121-137
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis.
Wen J, Feng Y, Xue L, Yuan S, Chen Q, Luo A, Wang S, Zhang J
Gut microbes 2024 Jan-Dec;16(1):2412381
Gut microbes 2024 Jan-Dec;16(1):2412381
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis.
Hu X, Zou M, Zheng W, Zhu M, Hou Q, Gao H, Zhang X, Liu Y, Cheng Z
Respiratory research 2024 Feb 24;25(1):100
Respiratory research 2024 Feb 24;25(1):100
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Li X, Li J, Ji J, Li S, Yao X, Fan H, Yao R
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis.
Liu W, Yang H, Xu Q, Lee J, Sun J, Xue S, Yang X, Sun X, Che C
International immunopharmacology 2024 Dec 5;142(Pt A):113094
International immunopharmacology 2024 Dec 5;142(Pt A):113094
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Mao N, Yu Y, Lu X, Yang Y, Liu Z, Wang D
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
Guizhi Shaoyao Zhimu Decoction ameliorates gouty arthritis in rats via altering gut microbiota and improving metabolic profile.
Bian M, Zhu C, Nie A, Zhou Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155800
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155800
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Yan Q, Song C, Liu H, Li Y, Ma J, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
International immunopharmacology 2024 Aug 20;137:112448
International immunopharmacology 2024 Aug 20;137:112448
Association of IL-9 Cytokines with Hepatic Injury in Echinococcus granulosus Infection.
Zhou T, Xu X, Zhu J, Aizezi M, Aierken A, Meng M, He R, Aimulajiang K, Wen H
Biomolecules 2024 Aug 14;14(8)
Biomolecules 2024 Aug 14;14(8)
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Liu J, Liao X, Li N, Xu Z, Yang W, Zhou H, Liu Y, Zhang Z, Wang G, Hou S
MedComm 2024 Apr;5(4):e534
MedComm 2024 Apr;5(4):e534
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2.
Lin K, Zheng W, Guo M, Zhou R, Zhang M, Liu T
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167089
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167089
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Cai Q, Zhao C, Xu Y, Lin H, Jia B, Huang B, Lin S, Chen D, Jia P, Wang M, Lin W, Zhang L, Chu J, Peng J
Journal of ethnopharmacology 2024 Apr 24;324:117712
Journal of ethnopharmacology 2024 Apr 24;324:117712
Escherichia coli Promotes Endothelial to Mesenchymal Transformation of Liver Sinusoidal Endothelial Cells and Exacerbates Nonalcoholic Fatty Liver Disease Via Its Flagellin.
Shen B, Gu T, Shen Z, Zhou C, Guo Y, Wang J, Li B, Xu X, Li F, Zhang Q, Cai X, Dong H, Lu L
Cellular and molecular gastroenterology and hepatology 2023;16(6):857-879
Cellular and molecular gastroenterology and hepatology 2023;16(6):857-879
Protective effects of Scutellariae Radix Carbonisata-derived carbon dots on blood-heat and hemorrhage rats.
Zhang M, Cheng J, Luo J, Li C, Hou T, Zhao Y, Wang Y, Qu H, Kong H
Frontiers in pharmacology 2023;14:1118550
Frontiers in pharmacology 2023;14:1118550
TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea.
Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z, Xie H, Li J, Liu F, Xiao W
PeerJ 2023;11:e15976
PeerJ 2023;11:e15976
Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Li F, Zhang Z, Bai Y, Che Q, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury.
Wang S, Wang R, Chen J, Yang B, Shu J, Cheng F, Tao Y, Shi K, Wang C, Wang J, Xia K, Zhang Y, Chen Q, Liang C, Tang J, Li F
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:27-42
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:27-42
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Zhou W, Kang S, Wang F, Qin Y, Liu J, Xiao X, Chen X, Zhang D
European journal of pharmacology 2023 Nov 5;958:176043
European journal of pharmacology 2023 Nov 5;958:176043
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Zhao L, Miao Y, Shan B, Zhao C, Peng C, Gong J
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076
Inflammation 2023 Jun;46(3):1061-1076
Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p.
Li X, Cao Y, Xu X, Wang C, Ni Q, Lv X, Yang C, Zhang Z, Qi X, Song G
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):995-1014
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):995-1014
IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders.
Li S, Liu H, Qian Y, Jiang L, Liu S, Liu Y, Liu C, Gu X
International immunopharmacology 2023 Jan;114:109479
International immunopharmacology 2023 Jan;114:109479
Region-resolved multi-omics of the mouse eye.
Xiang H, Zhang B, Wang Y, Xu N, Zhang F, Luo R, Ji M, Ding C
Cell reports 2023 Feb 28;42(2):112121
Cell reports 2023 Feb 28;42(2):112121
Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy.
Zhu TT, Wang H, Gu HW, Ju LS, Wu XM, Pan WT, Zhao MM, Yang JJ, Liu PM
Journal of nanobiotechnology 2023 Feb 10;21(1):52
Journal of nanobiotechnology 2023 Feb 10;21(1):52
In vitro validation: GLY alleviates UV-induced corneal epithelial damage through the HMGB1-TLR/MyD88-NF-κB signaling pathway.
Chen X, Zheng X, Shen T, He T, Zhao Y, Dong Y
Acta histochemica 2023 Dec;125(8):152111
Acta histochemica 2023 Dec;125(8):152111
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
Lv S, Zhang Z, Su X, Li W, Wang X, Pan B, Li H, Zhang H, Wang Y
Frontiers in endocrinology 2022;13:1106875
Frontiers in endocrinology 2022;13:1106875
Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway.
Ding Q, Liu W, Liu X, Ding C, Zhao Y, Dong L, Chen H, Sun S, Zhang Y, Zhang J, Wu M
Frontiers in bioengineering and biotechnology 2022;10:860515
Frontiers in bioengineering and biotechnology 2022;10:860515
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
Xu T, Hu S, Liu Y, Sun K, Luo L, Zeng L
Nutrients 2022 Sep 5;14(17)
Nutrients 2022 Sep 5;14(17)
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
Zhan H, Pu Q, Long X, Lu W, Wang G, Meng F, Liao Z, Lan X, Chen M
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
Zhou P, Lai J, Li Y, Deng J, Zhao C, Huang Q, Yang F, Yang S, Wu Y, Tang X, Huang F, Wang L, Huang X, Zou W, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Ye J, Zheng J, Tian X, Xu B, Yuan F, Wang B, Yang Z, Huang F
Marine drugs 2022 Mar 25;20(4)
Marine drugs 2022 Mar 25;20(4)
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Xia X, Lin H, Luo F, Wu X, Zhu L, Chen S, Luo H, Ye F, Peng X, Zhang Y, Yang G, Lin Q
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
Chen C, Wang J, Liang Z, Li M, Fu D, Zhang L, Yang X, Guo Y, Ge D, Liu Y, Sun B
Biomaterials advances 2022 Aug;139:213005
Biomaterials advances 2022 Aug;139:213005
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