21854-1-AP

antibody from Proteintech Group

Targeting: NR3C2 MLR, MR

Provider product page for 21854-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 21854-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21854-1-AP, RRID:AB_10858785
Product name: NR3C2 antibody
Antibody type: Polyclonal
Description: NR3C2 antibody (Cat. #21854-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NR3C2 protein structure - 21854-1-AP shown in red.

Submitted references An in Vitro triple screen model for human mineralocorticoid receptor activity.

Liu H, Konzen S, Coy A, Rege J, Gomez-Sanchez CE, Rainey WE, Turcu AF
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106568

Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats.

Hao J, Qiang P, Fan L, Xiong Y, Chang Y, Yang F, Wang X, Shimosawa T, Mu S, Xu Q
Scientific reports 2024 May 1;14(1):9976

Propofol-induced LINC01133 inhibits the progression of colorectal cancer via miR-186-5p/NR3C2 axis.

Yao Y, Zhang F, Liu F, Xia D
Environmental toxicology 2024 Apr;39(4):2265-2284

Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration.

Wen TZ, Fu WJ, Xiao SQ, Wang S, Li TR, Chen XY, Chen HY, Luo J, Bian XW, Yao XH
Pathology, research and practice 2024 Apr;256:155251

Prognostic model construction and target identification of Si-Wu-Tang against breast cancer.

Zhang Z, Zhang Z, Song J, Wu W, Chen Y, Li J, Wang Y, Zhao P
Heliyon 2023 Oct;9(10):e20709

Validation of prognostic signature and exploring the immune-related mechanisms for NR3C2 in clear cell renal cell carcinoma.

Chen D, Yin Z, Chen Y, Bai Y, You B, Sun Y, Wu Y
Translational cancer research 2023 Oct 31;12(10):2518-2532

The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes.

Carceller-Zazo E, Sevilla LM, Pons-Alonso O, Chiner-Oms Á, Amazit L, An Vu T, Vitellius G, Viengchareun S, Comas I, Jaszczyszyn Y, Abella M, Alegre-Martí A, Estébanez-Perpiñá E, Lombès M, Pérez P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22709

NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation.

Chen X, Li W, Chang C
Autoimmunity 2023 Dec;56(1):2189135

MicroRNA-155-5p Targets NR3C2 to Promote Malignant Progression of Clear Cell Renal Cell Carcinoma.

Yan C, Wang P, Zhao C, Yin G, Meng X, Li L, Cai S, Meng B
Kidney & blood pressure research 2022;47(5):354-362

Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats.

Chang Y, Ben Y, Li H, Xiong Y, Chen G, Hao J, Ma X, Gao X, Qiang P, Shimosawa T, Wang X, Yang F, Xu Q
Journal of the renin-angiotensin-aldosterone system : JRAAS 2022;2022:1283729

Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone.

Qiang P, Hao J, Yang F, Han Y, Chang Y, Xian Y, Xiong Y, Gao X, Liang L, Shimosawa T, Xu Q
Frontiers in immunology 2022;13:948658

High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction.

Yuan Y, Miao Y, Ren T, Huang F, Qian L, Chen X, Zuo Y, Zhang HG, He J, Qiao C, Du Q, Wu Q, Zhang W, Zhu C, Xu Y, Wu D, Shi W, Jiang J, Xu G, Zheng H
EMBO reports 2022 Jan 5;23(1):e53466

Melatonin prevents experimental central serous chorioretinopathy in rats.

Yu S, Cui K, Wu P, Wu B, Lu X, Huang R, Tang X, Lin J, Yang B, Zhao J, He Q, Liang X, Xu Y
Journal of pineal research 2022 Aug;73(1):e12802

Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway.

Ma X, Qiang P, Chen G, Wang Z, Wang X, Xu Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5533911

UUO induces lung fibrosis with macrophage-myofibroblast transition in rats.

Yang F, Chang Y, Zhang C, Xiong Y, Wang X, Ma X, Wang Z, Li H, Shimosawa T, Pei L, Xu Q
International immunopharmacology 2021 Apr;93:107396

Hu D, Dong R, Zhang Y, Yang Y, Chen Z, Tang Y, Fu M, Xu X, Tu L
Molecular medicine reports 2020 Sep;22(3):1859-1867

Long Non-Coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Hypertension by Modulating the Hsa-miR-124-3p/Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) and Hsa-miR-135a-5p/NR3C2 Axis.

Luo L, Wang Y, Hu P, Wu J
Medical science monitor : international medical journal of experimental and clinical research 2020 Mar 29;26:e920478

Aldosterone from endometrial glands is benefit for human decidualization.

Li SY, Song Z, Yan YP, Li B, Song MJ, Liu YF, Yang ZS, Li MY, Liu AX, Quan S, Yang ZM
Cell death & disease 2020 Aug 13;11(8):679

Response of the maternal hypothalamus to cold stress during late pregnancy in rats.

Wang D, Xu B, Wang J, Wang H, Guo J, Ji H, Li S, Wu R, Yang H, Lian S
Brain research 2019 Nov 1;1722:146354

Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.

Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388

Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.

Lian S, Xu B, Wang D, Wang L, Li W, Yao R, Ji H, Wang J, Guo J, Li S, Yang H
Behavioural brain research 2019 Feb 1;359:304-311

Identification of mineralocorticoid receptor target genes in the mouse hippocampus.

van Weert LTCM, Buurstede JC, Sips HCM, Vettorazzi S, Mol IM, Hartmann J, Prekovic S, Zwart W, Schmidt MV, Roozendaal B, Tuckermann JP, Sarabdjitsingh RA, Meijer OC
Journal of neuroendocrinology 2019 Aug;31(8):e12735

Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.

Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H
Behavioural brain research 2018 Jul 2;346:1-10

Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.

Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 21854-1-AP(NR3C2 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using NR3C2 antibody 21854-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 21854-1-AP(NR3C2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 21854-1-AP(NR3C2 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue