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Learn18409-1-AP
antibody from Proteintech Group
Targeting: TOMM40
C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [136]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 18409-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18409-1-AP, RRID:AB_2303725
- Product name
- TOMM40 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOMM40 antibody (Cat. #18409-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pharmacological stabilization of hypoxia-inducible factor 1-α dampens the interferon response and promotes glycolysis in Aicardi-Goutières syndrome.
Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease.
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus.
Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.
Proximity Labeling Reveals RNA-Binding Proteins Associating with the Human Mitochondrial Import Receptor TOMM20.
No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases.
Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models.
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1.
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30.
SerpinA3N inhibits mitochondrial complex I activity to prevent neuron ferroptosis following cerebral ischemic stroke.
SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.
Upregulated astrocytic HDAC7 induces depression-like disorders via deacetylating PINK1 and inhibiting mitophagy.
Microtubule nucleation at the Golgi-related membrane organelles of mouse neurons.
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury.
Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.
CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome.
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes.
The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells.
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis.
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control.
Protocol for mitochondria lipid encapsulation using a dual-tube system for mitochondria transfer therapy.
Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease.
Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy.
USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40.
Mass spectrometry-based proteomics to study mutants and interactomes of mitochondrial translocation proteins.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Full-length GSDME mediates pyroptosis independent from cleavage.
S-1-Propenylcysteine Enhances Endurance Capacity of Mice by Stimulating Fatty Acid Metabolism via Muscle Isoform of Carnitine Acyltransferase-1.
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
The Large GTPase Guanylate-Binding Protein-1 (GBP-1) Promotes Mitochondrial Fission in Glioblastoma.
Role of Exogenous Pyruvate in Maintaining Adenosine Triphosphate Production under High-Glucose Conditions through PARP-Dependent Glycolysis and PARP-Independent Tricarboxylic Acid Cycle.
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Opposing roles for AMPK in regulating distinct mitophagy pathways.
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Beta-lapachone ameliorates the progression of primary sclerosing cholangitis pathogenesis in rodent models.
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.
Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya disease.
BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam.
Identification of Proximity Interactors of Mammalian Nucleoid Proteins by BioID.
Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction.
Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways.
RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.
MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
The Translocase of the Outer Mitochondrial Membrane (TOM40) is required for mitochondrial dynamics and neuronal integrity in Dorsal Root Ganglion Neurons.
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
TOM40 regulates the progression of nasopharyngeal carcinoma through ROS-mediated AKT/mTOR and p53 signaling.
A mitochondrial iron-responsive pathway regulated by DELE1.
The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates.
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes.
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Low Expression of Mitofusin 1 Gene Leads to Mitochondrial Dysfunction and Embryonic Genome Activation Failure in Ovine-Bovine Inter-Species Cloned Embryos.
SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins.
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.
DELE1 tracks perturbed protein import and processing in human mitochondria.
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance.
Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.
VPS13D bridges the ER to mitochondria and peroxisomes via Miro.
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
Identification and detection of mecciRNAs.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration.
Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys.
Dependence of PINK1 accumulation on mitochondrial redox system.
Mitochondrial dysfunction caused by novel ATAD3A mutations.
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.
TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels.
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Batignes M, Luka M, Jagtap S, de Cevins C, Nemazanyy I, Leib J, Fali T, Pierga A, Zarhrate M, García-Paredes V, Carbone F, Pérot BP, Neven B, Bader-Meunier B, Quartier P, Hully M, Belot A, Lepelley A, Frémond ML, Fischer A, Ménager MM
Nature communications 2026 Mar 3;17(1)
Nature communications 2026 Mar 3;17(1)
Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease.
Wei X, Munechika K, Sun Y, Wan Y, Xia T, Hou Y, Song W, Yugandhar K, Wang Y, Lee SI, Sha Z, Zhou Y, Feng W, Zhu J, Tang Y, Luo W, Cheng F, Gan L, Yu H
bioRxiv : the preprint server for biology 2026 Mar 16;
bioRxiv : the preprint server for biology 2026 Mar 16;
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105
The EMBO journal 2026 Jan;45(1):64-105
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Wang J, Yu W, Cai S, Wei H, Peng B, Qian J, Chen Y, Zheng F, Jiang H, Xie Q, Zhou H, Fang H, Lyu J
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus.
Gao XN, Shu HB, Li M
Pathogens (Basel, Switzerland) 2026 Jan 9;15(1)
Pathogens (Basel, Switzerland) 2026 Jan 9;15(1)
Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.
Yang M, Oatley MJ, Miao D, Maddison LA, Oatley JM
Cell reports 2026 Jan 27;45(1):116731
Cell reports 2026 Jan 27;45(1):116731
Proximity Labeling Reveals RNA-Binding Proteins Associating with the Human Mitochondrial Import Receptor TOMM20.
Akram S, Zittlau KI, Sharma K, Fitzgerald JC, Rafiq N, Maček B, Jansen RP
Journal of proteome research 2026 Feb 6;25(2):1055-1070
Journal of proteome research 2026 Feb 6;25(2):1055-1070
No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases.
Marchais M, Pennisi A, Pierga A, Lepelley A, Cagnard N, Bole C, Nitschke P, Hamici M, Rieux-Laucat F, Schiff M, Munnich A, Rötig A
European journal of immunology 2026 Apr;56(4):e70176
European journal of immunology 2026 Apr;56(4):e70176
Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models.
Abd Alla J, Perhal A, Fu X, Langer A, Faramawy YE, Quitterer U
Cell reports. Medicine 2026 Apr 21;7(4):102707
Cell reports. Medicine 2026 Apr 21;7(4):102707
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1.
Xu Z, Gao X, Rong D, Wang J, Gao L, Tang M, Chen Y, Zhang Y, Xie L, Wang L, Lu G, Lu JH, Liu W, Shen HM
International journal of biological sciences 2025;21(9):4252-4269
International journal of biological sciences 2025;21(9):4252-4269
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30.
Kazi NH, Klink N, Gallant K, Kipka GM, Gersch M
Nature structural & molecular biology 2025 Sep;32(9):1776-1786
Nature structural & molecular biology 2025 Sep;32(9):1776-1786
SerpinA3N inhibits mitochondrial complex I activity to prevent neuron ferroptosis following cerebral ischemic stroke.
Liu X, Li G, Guo Y, Li R, Yi S, Ding S, Wan J
Experimental neurology 2025 Oct;392:115370
Experimental neurology 2025 Oct;392:115370
SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40.
Hu L, Li J, Guo H, Su L, Dong P, Huang J, Liu Y, Liu X, Luo Z, Xiong W, Ju Z, Zhou Q, Wang H, Wang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03408
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03408
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.
Wang B, Han X, Lin X, Wang J, You C, Chen K, Chen Y, Meng F, Jiang H, Zheng F, Zhang Y, Lyu J, Bai Y, Qu X, Zhou D, Jiang M, Cui W, Lyu J, Fang H
Nature communications 2025 Nov 5;16(1):9772
Nature communications 2025 Nov 5;16(1):9772
Upregulated astrocytic HDAC7 induces depression-like disorders via deacetylating PINK1 and inhibiting mitophagy.
Yue RZ, Guo X, Li CJ, Wu LJ, Liu YT, Hu J, Yan BK, Lin HT, Tang YL, Yan WM, Xiao S, Hao Y, Ye J
Journal of neuroinflammation 2025 Nov 24;22(1):276
Journal of neuroinflammation 2025 Nov 24;22(1):276
Microtubule nucleation at the Golgi-related membrane organelles of mouse neurons.
Kasai H, Hayashi K
Histochemistry and cell biology 2025 May 28;163(1):61
Histochemistry and cell biology 2025 May 28;163(1):61
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury.
Weng W, He Z, Ma Z, Huang J, Han Y, Feng Q, Qi W, Peng Y, Wang J, Gu J, Wang W, Lin Y, Jiang G, Jiang J, Feng J
Cell death and differentiation 2025 Mar;32(3):530-545
Cell death and differentiation 2025 Mar;32(3):530-545
Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.
Phillips E, van Enk S, Kildgaard S, Schlue S, Göttmann M, Jennings V, Bethke F, Müller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V
Molecular oncology 2025 Mar;19(3):785-807
Molecular oncology 2025 Mar;19(3):785-807
CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome.
Huang Y, Chen Z, Deng W, Jiang Y, Pan Y, Yuan Z, Hu H, Wu Y, Hu Y
Cell death & disease 2025 Mar 12;16(1):173
Cell death & disease 2025 Mar 12;16(1):173
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes.
Zhao Y, Dong Y, Zheng Q, Zhao Y, Ni Y, Qiu P, Chen C, Xu M, Hong C, Shen T
Investigative ophthalmology & visual science 2025 Jun 2;66(6):6
Investigative ophthalmology & visual science 2025 Jun 2;66(6):6
The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells.
Katrii T, Freywald T, Estrada MG, El Zawily A, Toosi B, Vizeacoumar FS, Vizeacoumar FJ, Freywald A, Leary SC
Cancer cell international 2025 Jul 19;25(1):272
Cancer cell international 2025 Jul 19;25(1):272
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
Sun N, Barta H, Chaudhuri S, Chen K, Jin J, Luo H, Yang M, Krigman J, Zhang R, Sanghvi S, Sekine S, Sanders H, Kolonay D, Patel M, Baskin K, Singh H, Zhang P, Xin G, Finkel T
Nature communications 2025 Jul 1;16(1):5465
Nature communications 2025 Jul 1;16(1):5465
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis.
Zhang MN, Duan R, Chen GH, Chen MJ, Hong CG, Wang X, Pang ZL, Chen CY, Liu HF, Zhong D, Xie H, Hu WB, Liu ZZ
Communications biology 2025 Jan 16;8(1):68
Communications biology 2025 Jan 16;8(1):68
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
Jiahui W, Xiang Y, Youhuan Z, Xiaomin M, Yuanzhu G, Dejian Z, Jie W, Yinkun F, Shi F, Juncheng S, Masha H, Marcia H, Peiyi W, Yingjie X, Wen Y
Molecular cell 2025 Feb 6;85(3):638-651.e9
Molecular cell 2025 Feb 6;85(3):638-651.e9
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Cai D, Chen C, Meekrathok P, Zeng W, Wang Z, Peng Z, Mo Y, Xu X, Wang J, Qiu J
EMBO reports 2025 Dec;26(23):5959-5981
EMBO reports 2025 Dec;26(23):5959-5981
Mitochondrial components secretion in extracellular vesicles promotes alveolar epithelial mitochondrial quality control.
Liu B, Han Y, Jin Y, Ye M, Yang Z, Yang J, Zhu M, Zhao X, Jin Y, Yin Y
Nature communications 2025 Dec 5;17(1):833
Nature communications 2025 Dec 5;17(1):833
Protocol for mitochondria lipid encapsulation using a dual-tube system for mitochondria transfer therapy.
Hamanaka G, Back DB, Licastro E, Ishikane S, Nakano T, Hayakawa K
STAR protocols 2025 Dec 19;6(4):104174
STAR protocols 2025 Dec 19;6(4):104174
Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease.
Tian J, Meka SS, Wang T, Guo L, Du H
Journal of Alzheimer's disease : JAD 2025 Aug;106(4):1545-1556
Journal of Alzheimer's disease : JAD 2025 Aug;106(4):1545-1556
Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy.
Jiang S, Jia H, Hou Q, Jin L, Ahsan MA, Li G, Guan T, Zhao J, Liu Z, Xie J, Cheng H, Hao C, Wan J, Ni Z, Wang N, Shi J, Zheng C, Zhang R, Yan D, Chen H, Jia W, Shen N, Hu C, Liu Z
Cell reports. Medicine 2025 Aug 19;6(8):102249
Cell reports. Medicine 2025 Aug 19;6(8):102249
USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40.
Gao X, Liu J, Jia B, Guo J
Journal of biochemical and molecular toxicology 2025 Apr;39(4):e70258
Journal of biochemical and molecular toxicology 2025 Apr;39(4):e70258
Mass spectrometry-based proteomics to study mutants and interactomes of mitochondrial translocation proteins.
Oeljeklaus S, Sharma L, Bender J, Warscheid B
Methods in enzymology 2024;707:101-152
Methods in enzymology 2024;707:101-152
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Full-length GSDME mediates pyroptosis independent from cleavage.
Zhou B, Jiang ZH, Dai MR, Ai YL, Xiao L, Zhong CQ, Wu LZ, Chen QT, Chen HZ, Wu Q
Nature cell biology 2024 Sep;26(9):1545-1557
Nature cell biology 2024 Sep;26(9):1545-1557
S-1-Propenylcysteine Enhances Endurance Capacity of Mice by Stimulating Fatty Acid Metabolism via Muscle Isoform of Carnitine Acyltransferase-1.
Kunimura K, Nakamoto M, Ushijima M
The Journal of nutrition 2024 Sep;154(9):2707-2716
The Journal of nutrition 2024 Sep;154(9):2707-2716
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Raby A, Missiroli S, Sanatine P, Langui D, Pansiot J, Beaude N, Vezzana L, Saleh R, Marinello M, Laforge M, Pinton P, Buj-Bello A, Burgo A
iScience 2024 Sep 20;27(9):110683
iScience 2024 Sep 20;27(9):110683
The Large GTPase Guanylate-Binding Protein-1 (GBP-1) Promotes Mitochondrial Fission in Glioblastoma.
Kalb RC, Nyabuto GO, Morran MP, Maity S, Justinger JS, Nestor-Kalinoski AL, Vestal DJ
International journal of molecular sciences 2024 Oct 19;25(20)
International journal of molecular sciences 2024 Oct 19;25(20)
Role of Exogenous Pyruvate in Maintaining Adenosine Triphosphate Production under High-Glucose Conditions through PARP-Dependent Glycolysis and PARP-Independent Tricarboxylic Acid Cycle.
Yako H, Niimi N, Takaku S, Kato A, Kato K, Sango K
International journal of molecular sciences 2024 Oct 15;25(20)
International journal of molecular sciences 2024 Oct 15;25(20)
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).
Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P
International journal of molecular sciences 2024 Oct 1;25(19)
International journal of molecular sciences 2024 Oct 1;25(19)
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
Lu JL, Dai Y, Ji K, Peng GX, Li H, Yan C, Shen B, Zhou XL
Nucleic acids research 2024 Nov 27;52(21):13351-13367
Nucleic acids research 2024 Nov 27;52(21):13351-13367
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Singh S, Dransfeld UE, Ambaw YA, Lopez-Scarim J, Farese RV Jr, Walther TC
Cell 2024 Nov 27;187(24):6820-6834.e24
Cell 2024 Nov 27;187(24):6820-6834.e24
Opposing roles for AMPK in regulating distinct mitophagy pathways.
Longo M, Bishnu A, Risiglione P, Montava-Garriga L, Cuenco J, Sakamoto K, MacKintosh C, Ganley IG
Molecular cell 2024 Nov 21;84(22):4350-4367.e9
Molecular cell 2024 Nov 21;84(22):4350-4367.e9
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
Isaac RS, Tullius TW, Hansen KG, Dubocanin D, Couvillion M, Stergachis AB, Churchman LS
Nature structural & molecular biology 2024 Mar;31(3):568-577
Nature structural & molecular biology 2024 Mar;31(3):568-577
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Bi PY, Killackey SA, Schweizer L, Arnoult D, Philpott DJ, Girardin SE
Communications biology 2024 Mar 30;7(1):391
Communications biology 2024 Mar 30;7(1):391
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation.
Li ZH, Zhou XL
Nucleic acids research 2024 Jul 22;52(13):7825-7842
Nucleic acids research 2024 Jul 22;52(13):7825-7842
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Geroyska S, Mejia I, Chan AA, Navarrete M, Pandey V, Kharpatin S, Noguti J, Wang F, Srole D, Chou TF, Wohlschlegel J, Nemeth E, Damoiseaux R, Shackelford DB, Lee DJ, Díaz B
Cancer research communications 2024 Jul 1;4(7):1815-1833
Cancer research communications 2024 Jul 1;4(7):1815-1833
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
Goldman A, Mullokandov M, Zaltsman Y, Regev L, Levin-Zaidman S, Gross A
EMBO reports 2024 Jan;25(1):45-67
EMBO reports 2024 Jan;25(1):45-67
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
Beta-lapachone ameliorates the progression of primary sclerosing cholangitis pathogenesis in rodent models.
Woo SH, Lee SH, Moon SJ, Han J, Seo KS, Lee H, Lee CH, Hwang JH
Life sciences 2024 Jan 15;337:122342
Life sciences 2024 Jan 15;337:122342
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.
Xu J, Shi C, Yuan F, Ding Y, Xie Y, Liu Y, Zhu F, Lu H, Duan C, Hu J, Jiang L
Bioactive materials 2024 Feb;32:427-444
Bioactive materials 2024 Feb;32:427-444
Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya disease.
Li CY, Chen LW, Tsai MC, Chou YY, Lin PX, Chang YM, Hwu WL, Chien YH, Lin JL, Chen HA, Lee NC, Su PH, Hsieh TC, Klinkhammer H, Wang YC, Huang YT, Krawitz PM, Lin SH, Huang LLH, Chiang PM, Shih MH, Chen PC
EBioMedicine 2024 Dec;110:105476
EBioMedicine 2024 Dec;110:105476
BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
Hui Y, Leng J, Jin D, Wang G, Liu K, Bu Y, Wang Q
Cancer biology & therapy 2024 Dec 31;25(1):2375440
Cancer biology & therapy 2024 Dec 31;25(1):2375440
Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam.
Vasquez V, Kodavati M, Mitra J, Vedula I, Hamilton DJ, Garruto RM, Rao KS, Hegde ML
Cell death & disease 2024 Dec 18;15(12):914
Cell death & disease 2024 Dec 18;15(12):914
Identification of Proximity Interactors of Mammalian Nucleoid Proteins by BioID.
Aaltonen MJ, Antonicka H
Methods in molecular biology (Clifton, N.J.) 2023;2615:153-172
Methods in molecular biology (Clifton, N.J.) 2023;2615:153-172
Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction.
Yang D, Li J, Li Z, Zhao M, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
Frontiers in molecular neuroscience 2023;16:1163981
Frontiers in molecular neuroscience 2023;16:1163981
Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.
Elhage R, Kelly M, Goudin N, Megret J, Legrand A, Nemazanyy I, Patitucci C, Quellec V, Wai T, Hamaï A, Ezine S
Frontiers in immunology 2023;14:1270268
Frontiers in immunology 2023;14:1270268
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression.
Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS
Nature cell biology 2023 Nov;25(11):1575-1589
Nature cell biology 2023 Nov;25(11):1575-1589
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
Wang L, Hilander T, Liu X, Tsang HY, Eriksson O, Jackson CB, Varjosalo M, Zhao H
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.
Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T
Cell reports 2023 May 30;42(5):112454
Cell reports 2023 May 30;42(5):112454
Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways.
Yasuda T, Ishihara T, Ichimura A, Ishihara N
Cell reports 2023 May 30;42(5):112434
Cell reports 2023 May 30;42(5):112434
RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.
Li Z, Lai M, Li J, Yang D, Zhao M, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Zhao D, Qiao J, Yang L
Molecular neurobiology 2023 Mar;60(3):1391-1407
Molecular neurobiology 2023 Mar;60(3):1391-1407
MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
Pujol C, Lebigot E, Gaignard P, Galai S, Kraoua I, Bault JP, Dard R, Youssef-Turki IB, Omar S, Boutron A, Wai T, Slama A
Brain : a journal of neurology 2023 Mar 1;146(3):858-864
Brain : a journal of neurology 2023 Mar 1;146(3):858-864
The Translocase of the Outer Mitochondrial Membrane (TOM40) is required for mitochondrial dynamics and neuronal integrity in Dorsal Root Ganglion Neurons.
Overmeyer C, Jorgensen K, Vohra BPS
Molecular and cellular neurosciences 2023 Jun;125:103853
Molecular and cellular neurosciences 2023 Jun;125:103853
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
Meng K, Lu S, Li YY, Hu LL, Zhang J, Cao Y, Wang Y, Zhang CZ, He QY
EMBO reports 2023 Jun 5;24(6):e56282
EMBO reports 2023 Jun 5;24(6):e56282
TOM40 regulates the progression of nasopharyngeal carcinoma through ROS-mediated AKT/mTOR and p53 signaling.
Ran H, Zhang J, Zeng X, Wang Z, Liu P, Kang C, Qiu S, Zeng X, Zhang P
Discover oncology 2023 Jun 23;14(1):109
Discover oncology 2023 Jun 23;14(1):109
A mitochondrial iron-responsive pathway regulated by DELE1.
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth.
Ren X, Yan J, Zhao Q, Bao X, Han X, Zheng C, Zhou Y, Chen L, Wang B, Yang L, Lin X, Liu D, Lin Y, Li M, Fang H, Lu Z, Lyu J
Cell discovery 2023 Jul 25;9(1):76
Cell discovery 2023 Jul 25;9(1):76
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R
iScience 2023 Jul 21;26(7):107118
iScience 2023 Jul 21;26(7):107118
Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Jett KA, Baker ZN, Hossain A, Boulet A, Cobine PA, Ghosh S, Ng P, Yilmaz O, Barreto K, DeCoteau J, Mochoruk K, Ioannou GN, Savard C, Yuan S, Abdalla OH, Lowden C, Kim BE, Cheng HM, Battersby BJ, Gohil VM, Leary SC
The Journal of clinical investigation 2023 Jan 3;133(1)
The Journal of clinical investigation 2023 Jan 3;133(1)
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates.
Park D, Wu Y, Wang X, Gowrishankar S, Baublis A, De Camilli P
Nature communications 2023 Jan 28;14(1):455
Nature communications 2023 Jan 28;14(1):455
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P
Nature communications 2023 Feb 27;14(1):1121
Nature communications 2023 Feb 27;14(1):1121
The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.
Decourt C, Schaeffer J, Blot B, Paccard A, Excoffier B, Pende M, Nawabi H, Belin S
PLoS biology 2023 Apr;21(4):e3002044
PLoS biology 2023 Apr;21(4):e3002044
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes.
Prowse ENP, Chaudhary AR, Sharon D, Hendricks AG
Biophysical journal 2023 Apr 4;122(7):1168-1184
Biophysical journal 2023 Apr 4;122(7):1168-1184
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Cao X, Chen Y, Sang X, Xu S, Xie Z, Zhu Z, Wang P, Bi J, Xu L
Frontiers in aging neuroscience 2022;14:1013943
Frontiers in aging neuroscience 2022;14:1013943
Low Expression of Mitofusin 1 Gene Leads to Mitochondrial Dysfunction and Embryonic Genome Activation Failure in Ovine-Bovine Inter-Species Cloned Embryos.
Wu S, Zhao X, Wu M, Yang L, Liu X, Li D, Xu H, Zhao Y, Su X, Wei Z, Bai C, Su G, Li G
International journal of molecular sciences 2022 Sep 4;23(17)
International journal of molecular sciences 2022 Sep 4;23(17)
SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins.
Lone MA, Aaltonen MJ, Zidell A, Pedro HF, Morales Saute JA, Mathew S, Mohassel P, Bönnemann CG, Shoubridge EA, Hornemann T
The Journal of clinical investigation 2022 Sep 15;132(18)
The Journal of clinical investigation 2022 Sep 15;132(18)
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
Lai MY, Li J, Zhang XX, Wu W, Li ZP, Sun ZX, Zhao MY, Yang DM, Wang DD, Li W, Zhao DM, Zhou XM, Yang LF
Neural regeneration research 2022 Oct;17(10):2293-2299
Neural regeneration research 2022 Oct;17(10):2293-2299
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Wang R, Shang Y, Chen B, Xu F, Zhang J, Zhang Z, Zhao X, Wan X, Xu A, Wu L, Zhao G
Cell death & disease 2022 Oct 6;13(10):851
Cell death & disease 2022 Oct 6;13(10):851
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, Liu B, Yan C, Chen Y, He H, Meng Q, Song Z
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704
Nature communications 2022 Nov 7;13(1):6704
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron 2022 Mar 16;110(6):967-976.e8
Neuron 2022 Mar 16;110(6):967-976.e8
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Aaltonen MJ, Alecu I, König T, Bennett SA, Shoubridge EA
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease.
Li J, Lai M, Zhang X, Li Z, Yang D, Zhao M, Wang D, Sun Z, Ehsan S, Li W, Gao H, Zhao D, Yang L
Cell death & disease 2022 Feb 18;13(2):162
Cell death & disease 2022 Feb 18;13(2):162
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L
Cell 2022 Feb 17;185(4):712-728.e14
Cell 2022 Feb 17;185(4):712-728.e14
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.
Tillo M, Lamanna WC, Dwyer CA, Sandoval DR, Pessentheiner AR, Al-Azzam N, Sarrazin S, Gonzales JC, Kan SH, Andreyev AY, Schultheis N, Thacker BE, Glass CA, Dickson PI, Wang RY, Selleck SB, Esko JD, Gordts PLSM
The Journal of biological chemistry 2022 Aug;298(8):102159
The Journal of biological chemistry 2022 Aug;298(8):102159
DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E, Krumwiede L, Jae LT
Nature communications 2022 Apr 6;13(1):1853
Nature communications 2022 Apr 6;13(1):1853
Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance.
Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, Dunbar P, Scadden E, Yun TD, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith KC, Reynolds CP, Hajnoczky G, Hogarty MD
The EMBO journal 2022 Apr 19;41(8):e108272
The EMBO journal 2022 Apr 19;41(8):e108272
Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Lowden C, Boulet A, Boehler NA, Seecharran S, Rios Garcia J, Lowe NJ, Liu J, Ong JLK, Wang W, Ma L, Cheng AH, Senatore A, Monks DA, Liu BH, Leary SC, Cheng HM
Cell reports 2021 Sep 14;36(11):109704
Cell reports 2021 Sep 14;36(11):109704
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.
Croucher DC, Richards LM, Tsofack SP, Waller D, Li Z, Wei EN, Huang XF, Chesi M, Bergsagel PL, Sebag M, Pugh TJ, Trudel S
Nature communications 2021 Nov 3;12(1):6322
Nature communications 2021 Nov 3;12(1):6322
VPS13D bridges the ER to mitochondria and peroxisomes via Miro.
Guillén-Samander A, Leonzino M, Hanna MG, Tang N, Shen H, De Camilli P
The Journal of cell biology 2021 May 3;220(5)
The Journal of cell biology 2021 May 3;220(5)
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Yang W, Pang D, Chen M, Du C, Jia L, Wang L, He Y, Jiang W, Luo L, Yu Z, Mao M, Yuan Q, Tang P, Xia X, Cui Y, Jing B, Platero A, Liu Y, Wei Y, Worley PF, Xiao B
Developmental cell 2021 Mar 22;56(6):811-825.e6
Developmental cell 2021 Mar 22;56(6):811-825.e6
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T
EMBO molecular medicine 2021 Jun 7;13(6):e13579
EMBO molecular medicine 2021 Jun 7;13(6):e13579
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Luo H, Krigman J, Zhang R, Yang M, Sun N
Acta physiologica (Oxford, England) 2021 Jul;232(3):e13666
Acta physiologica (Oxford, England) 2021 Jul;232(3):e13666
Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Gauba E, Sui S, Tian J, Driskill C, Jia K, Yu C, Rughwani T, Wang Q, Kroener S, Guo L, Du H
Neurobiology of aging 2021 Feb;98:63-77
Neurobiology of aging 2021 Feb;98:63-77
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Yang Y, Zhang Y, Yang C, Fang F, Wang Y, Chang H, Chen Z, Chen P
Virology journal 2021 Feb 18;18(1):39
Virology journal 2021 Feb 18;18(1):39
Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.
Zhu X, Boulet A, Buckley KM, Phillips CB, Gammon MG, Oldfather LE, Moore SA, Leary SC, Cobine PA
eLife 2021 Feb 16;10
eLife 2021 Feb 16;10
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286
Nature cell biology 2021 Dec;23(12):1271-1286
Identification and detection of mecciRNAs.
Liu X, Yang Y, Shan G
Methods (San Diego, Calif.) 2021 Dec;196:147-152
Methods (San Diego, Calif.) 2021 Dec;196:147-152
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B
Cell metabolism 2021 Dec 7;33(12):2464-2483.e18
Cell metabolism 2021 Dec 7;33(12):2464-2483.e18
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Lei Y, Zhang X, Xu Q, Liu S, Li C, Jiang H, Lin H, Kong E, Liu J, Qi S, Li H, Xu W, Lu K
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration.
Sun Y, Wei X, Fang F, Shen Y, Wei H, Li J, Ye X, Zhan Y, Ye X, Liu X, Yang W, Li Y, Geng X, Huang X, Ruan Y, Qin Z, Yi S, Lyu J, Fang H, Yu Y
Journal of genetics and genomics = Yi chuan xue bao 2021 Aug 20;48(8):727-736
Journal of genetics and genomics = Yi chuan xue bao 2021 Aug 20;48(8):727-736
Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys.
Ruan F, Wu L, Yin H, Fang L, Tang C, Huang S, Fang L, Zuo Z, He C, Huang J
Environmental pollution (Barking, Essex : 1987) 2021 Aug 15;283:117028
Environmental pollution (Barking, Essex : 1987) 2021 Aug 15;283:117028
Dependence of PINK1 accumulation on mitochondrial redox system.
Gao F, Zhang Y, Hou X, Tao Z, Ren H, Wang G
Aging cell 2020 Sep;19(9):e13211
Aging cell 2020 Sep;19(9):e13211
Mitochondrial dysfunction caused by novel ATAD3A mutations.
Dorison N, Gaignard P, Bayot A, Gelot A, Becker PH, Fourati S, Lebigot E, Charles P, Wai T, Therond P, Slama A
Molecular genetics and metabolism 2020 Sep-Oct;131(1-2):107-113
Molecular genetics and metabolism 2020 Sep-Oct;131(1-2):107-113
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G
Science China. Life sciences 2020 Oct;63(10):1429-1449
Science China. Life sciences 2020 Oct;63(10):1429-1449
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.
Ogasawara E, Nakada K, Ishihara N
Pharmacological research 2020 Oct;160:105204
Pharmacological research 2020 Oct;160:105204
TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels.
Yang W, Shin HY, Cho H, Chung JY, Lee EJ, Kim JH, Kang ES
Cancers 2020 May 22;12(5)
Cancers 2020 May 22;12(5)
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, Li J, Chen D, Xu P, Jia M, Zhou H, Fang H, Lyu J, Yang Y
Journal of human genetics 2020 Mar;65(3):231-240
Journal of human genetics 2020 Mar;65(3):231-240
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Phu L, Rose CM, Tea JS, Wall CE, Verschueren E, Cheung TK, Kirkpatrick DS, Bingol B
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Zhang B, Jia K, Tian J, Du H
Biochemical and biophysical research communications 2020 Aug 20;529(2):314-320
Biochemical and biophysical research communications 2020 Aug 20;529(2):314-320
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, Tao Y, Wu L, Xu A, Lu H, Zhao G
Cellular signalling 2019 Oct;62:109337
Cellular signalling 2019 Oct;62:109337
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB
Nature 2019 Nov;575(7782):380-384
Nature 2019 Nov;575(7782):380-384
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z
Nature 2019 Nov;575(7782):375-379
Nature 2019 Nov;575(7782):375-379
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Violitzi F, Perivolidi VI, Thireou T, Grivas I, Haralambous S, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Wang Q, Tian J, Chen H, Du H, Guo L
Neurobiology of disease 2019 Jul;127:410-418
Neurobiology of disease 2019 Jul;127:410-418
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G
Nature communications 2019 Apr 5;10(1):1566
Nature communications 2019 Apr 5;10(1):1566
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P
Cell death & disease 2018 Nov 13;9(11):1129
Cell death & disease 2018 Nov 13;9(11):1129
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Kim JS, Ha JY, Yang SJ, Son JH
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Wang M, Chen Y, Guo Z, Yang C, Qi J, Fu Y, Chen Z, Chen P, Wang Y
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics 2017 Apr;13(4):e1006656
PLoS genetics 2017 Apr;13(4):e1006656
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W
Molecular neurodegeneration 2017 Apr 24;12(1):32
Molecular neurodegeneration 2017 Apr 24;12(1):32
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Gao J, Li M, Qin S, Zhang T, Jiang S, Hu Y, Deng Y, Zhang C, You D, Li H, Mu D, Zhang Z, Jiang C
Autophagy 2016;12(4):632-47
Autophagy 2016;12(4):632-47
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S
Scientific reports 2015 Nov 4;5:16064
Scientific reports 2015 Nov 4;5:16064
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 18409-1-AP(TOMM40 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Tom40 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Tom40. This antibody recognizes human,mouse,rat antigen. The Tom40 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 18409-1-AP(TOMM40 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 18409-1-AP(TOMM40 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
