55205-1-AP

antibody from Proteintech Group

Targeting: IGFBP5

Provider product page for 55205-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Validations
Western blot [1]

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Product number: 55205-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55205-1-AP, RRID:AB_2736835
Product name: IGFBP5 antibody
Antibody type: Polyclonal
Description: IGFBP5 antibody (Cat. #55205-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IGFBP5 protein structure - 55205-1-AP shown in red.

Submitted references PAPPA2 c.392G>C Heterozygous Mutation Associates Primary Open-Angle Glaucoma in a Chinese Family.

Wang G, Guo Z, Ren J, Zhang G, Tao H, Liu Y, Zheng S, Zhang X, Wang D, Zhao R, Cui H, Zhu S, Xu H, Duan S, Li H
Human mutation 2026;2026:5591097

SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments.

Niu H, Zhang S, Mao J, Wu Y, Chen Y, Chen J, Wang R, Zhang G, Zhang P, Zhang X, Wang S, Jia D, Wang J, Zhou L, Lai M, Guo G, Han X
Cell stem cell 2026 May 7;33(5):872-890.e11

Glycolytic reprogramming mediated by the ADAM12/IGF1 axis promotes ossification of the posterior longitudinal ligament.

Zhao Q, Wu H, Xie D, Shi M, Niu B, Yang L
Cell death discovery 2026 Mar 25;12(1)

Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Zhou Y, Li WL, Liu ZQ, Ai WQ, Kou JX, Fan HW, Han ZT, Hu YZ, Zhang HH, Jia JJ, Zeng Y, Guo ZY, Man HY, Lu YM, Liu D, Zhu LQ
Nature neuroscience 2026 Feb;29(2):358-373

IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.

Wang S, Song C, Chi K, Fu Z, Zhang X, Geng X, Liu C, Cai G, Chen X, He JC, Hong Q, Wu D
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544

IGFBP5 as a Novel Basolateral Secretion Marker in the Retinal Pigment Epithelium.

Digsby KM, Zhang Q, Perera ND, Karoukis A, DenDekker A, Fahim AT, Miller JML
Advances in experimental medicine and biology 2025;1468:357-362

Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling.

Yang E, Xu R, Tu L, Zhang H, Luo S, Liang H, Liu Y, Gu S, Zhao Y, Huang X, Zan T
Burns & trauma 2025;13:tkaf057

IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury.

Yang C, Meng X, Xia C, Sun Y, Ren Y, Wang J, Li Y, Wang X
Journal of translational medicine 2025 Oct 13;23(1):1080

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors.

Bastian K, Orozco-Moreno M, Thomas H, Hodgson K, Visser EA, Rossing E, Pijnenborg JFA, Eerden N, Wilson L, Saravannan H, Hanley O, Grimsley G, Frame F, Peng Z, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Maitland NJ, Heer R, Wang N, Goddard-Borger ED, Guerrero RH, Boltje TJ, Drake RR, Scott E, Elliott DJ, Munkley J
Cancer medicine 2025 May;14(10):e70959

IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy.

Hu X, Chen W, Yang M, Li M, Li X, Ouyang S
Cellular and molecular life sciences : CMLS 2025 May 27;82(1):215

Intratumor HIF-1α modulates production of a cachectic ligand to cause host wasting.

Xiao G, Li Y, Hu Y, Tan K, Wang M, Zhu K, San M, Cheng Q, Tayier D, Hu T, Dang P, Li J, Cheng C, Perrimon N, Yang Z, Song W
Cell insight 2025 Jun;4(3):100247

IGFBP5 Promotes Atherosclerosis in APOE(-/-) Mice Through Phenotypic Transformation of VSMCs.

Xiang A, Guan H, Su P, Zhang L, Chen X, Yu Q
Current issues in molecular biology 2025 Jul 17;47(7)

Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling.

Waters JA, Lucht C, Howe S, Jordan GJ, Urbano I, Gilbert SF, Cripps RM, Robinson M, House CD
iScience 2025 Aug 15;28(8):113034

A molecular brain atlas reveals cellular shifts during the repair phase of stroke.

Weber RZ, Achón Buil B, Rentsch NH, Bosworth A, Zhang M, Kisler K, Tackenberg C, Rust R
Journal of neuroinflammation 2025 Apr 18;22(1):112

IGFBP5, as a Prognostic Indicator Promotes Tumor Progression and Correlates with Immune Microenvironment in Glioma.

Lin J, Huang G, Zeng Q, Zhang R, Lin Y, Li Y, Huang B, Pan H
Journal of Cancer 2024;15(1):232-250

Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract.

Xie J, Chen P, Mao S, Zang X, Cao R, Liu W, Wang X, Dai Y
Molecular biology reports 2024 Jun 14;51(1):755

Single-cell transcriptome dissecting the microenvironment remodeled by PD1 blockade combined with photodynamic therapy in a mouse model of oral carcinogenesis.

Dong Y, Zeng K, Ai R, Zhang C, Mao F, Dan H, Zeng X, Ji N, Li J, Jin X, Chen Q, Zhou Y, Li T
MedComm 2024 Jul;5(7):e636

Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence.

Sun Z, Li J, Liu H, Fan Z
Journal of oral rehabilitation 2024 Dec;51(12):2664-2674

Expression of insulin-like growth factor binding protein 5 in the vaginal wall tissues of older women with pelvic organ prolapse.

Duan Y, Chen Y, He Y, Gong R, Xia Z
Scientific reports 2024 Aug 7;14(1):18353

A molecular brain atlas reveals cellular shifts during the repair phase of stroke.

Weber RZ, Buil BA, Rentsch NH, Bosworth A, Zhang M, Kisler K, Tackenberg C, Zlokovic BV, Rust R
bioRxiv : the preprint server for biology 2024 Aug 22;

Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.

Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237

Intramuscular injection of mesenchymal stem cells augments basal muscle protein synthesis after bouts of resistance exercise in male mice.

Takegaki J, Sase K, Kono Y, Fujita T, Konishi S, Fujita S
Physiological reports 2024 Apr;12(7):e15991

Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors.

Yang W, Xu M, Xu S, Guan Q, Geng S, Wang J, Wei W, Xu H, Liu Y, Meng Y, Gao MQ
Breast cancer research : BCR 2023 Aug 29;25(1):100

Insulin-binding protein-5 down-regulates the balance of Th17/Treg.

Zhu M, Han H, Hu L, Cao Y, Fan Z
Frontiers in immunology 2022;13:1019248

The Implication of Serum Autoantibodies in Prognosis of Canine Mammary Tumors.

Yuan SH, Chang SC, Chou PY, Yang Y, Liu HP
Animals : an open access journal from MDPI 2022 Sep 18;12(18)

IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.

Song C, Wang S, Fu Z, Chi K, Geng X, Liu C, Cai G, Chen X, Wu D, Hong Q
Cell death & disease 2022 Apr 13;13(4):340

Significant association of serum autoantibodies to TYMS, HAPLN1 and IGFBP5 with early stage canine malignant mammary tumours.

Chang SC, Yuan SH, Li CY, Chang HM, Wang HC, Pan YA, Hsueh PC, Wu CC, Yang Y, Liu HP
Veterinary and comparative oncology 2021 Mar;19(1):172-182

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.

Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K
Cell reports 2020 Oct 20;33(3):108293

Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5.

Lai G, Wang L, Li Z, Zhao Y
American journal of physiology. Heart and circulatory physiology 2020 Dec 1;319(6):H1380-H1386

Insulin-Like Growth Factor Binding Protein 5-A Probable Target of Kidney Renal Papillary Renal Cell Carcinoma.

Wang S, Hong Q, Geng X, Chi K, Cai G, Wu D
BioMed research international 2019;2019:3210324

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor.

Xihua L, Shengjie T, Weiwei G, Matro E, Tingting T, Lin L, Fang W, Jiaqiang Z, Fenping Z, Hong L
Translational research : the journal of laboratory and clinical medicine 2019 Mar;205:33-43

Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5.

Mano SS, Uto K, Ebara M
Theranostics 2017;7(19):4658-4670

Fibulin-3 promotes muscle-invasive bladder cancer.

Han AL, Veeneman BA, El-Sawy L, Day KC, Day ML, Tomlins SA, Keller ET
Oncogene 2017 Sep 14;36(37):5243-5251

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71

Differences in IGF axis-related proteins in amniotic fluid of trisomy 21 and trisomy 18 using a multiple reaction monitoring approach.

Lai G, Zhang Y, Wang L, Zhang B, Zheng G, Wang X, Zhao X, Gao H, Zhao Y
Prenatal diagnosis 2014 Dec;34(12):1146-52

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IGFBP5 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IGFBP5. This antibody recognizes human antigen. The IGFBP5 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55205-1-AP.pdf

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