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- Antibody Data
- Antigen structure
- References [28]
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- Western blot [2]
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- Product number
- AF1404 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse/Rat TrkC Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) TrkC is observed and less than 2% cross-reactivity with recombinant mouse TrkB, recombinant rat TrkA, and rhTrkA is observed.
- Reactivity
- Mouse, Rat
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q6VNS1- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.
PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.
Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.
Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration.
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury.
Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines.
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats.
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.
Genetic Tracing of Ca(v)3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System.
Endogenous modulation of TrkB signaling by treadmill exercise after peripheral nerve injury.
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy.
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.
Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons.
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.
Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy.
TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ
Cell reports 2019 Mar 26;26(13):3522-3536.e5
Cell reports 2019 Mar 26;26(13):3522-3536.e5
PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.
Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, Akkuratova N, Bouçanova F, Médard JJ, Petitpré C, Landy MA, Zhang MD, Harrer P, Stendel C, Stucka R, Dusl M, Kastriti ME, Croci L, Lai HC, Consalez GG, Pattyn A, Ernfors P, Senderek J, Adameyko I, Lallemend F, Hadjab S, Chrast R
Cell reports 2019 Mar 26;26(13):3484-3492.e4
Cell reports 2019 Mar 26;26(13):3484-3492.e4
Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.
Zhang M, Wang Y, Geng J, Zhou S, Xiao B
Cell reports 2019 Feb 5;26(6):1419-1431.e4
Cell reports 2019 Feb 5;26(6):1419-1431.e4
Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration.
Wiszniak S, Schwarz Q
BMC neuroscience 2019 Apr 29;20(1):21
BMC neuroscience 2019 Apr 29;20(1):21
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury.
Takeoka A, Arber S
Cell reports 2019 Apr 2;27(1):71-85.e3
Cell reports 2019 Apr 2;27(1):71-85.e3
Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines.
Patil MJ, Hovhannisyan AH, Akopian AN
PloS one 2018;13(6):e0198601
PloS one 2018;13(6):e0198601
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats.
Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M
eNeuro 2018 Jan-Feb;5(1)
eNeuro 2018 Jan-Feb;5(1)
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.
Alshawaf AJ, Viventi S, Qiu W, D'Abaco G, Nayagam B, Erlichster M, Chana G, Everall I, Ivanusic J, Skafidas E, Dottori M
Scientific reports 2018 Jan 12;8(1):603
Scientific reports 2018 Jan 12;8(1):603
Genetic Tracing of Ca(v)3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System.
Bernal Sierra YA, Haseleu J, Kozlenkov A, Bégay V, Lewin GR
Frontiers in molecular neuroscience 2017;10:70
Frontiers in molecular neuroscience 2017;10:70
Endogenous modulation of TrkB signaling by treadmill exercise after peripheral nerve injury.
Arbat-Plana A, Cobianchi S, Herrando-Grabulosa M, Navarro X, Udina E
Neuroscience 2017 Jan 6;340:188-200
Neuroscience 2017 Jan 6;340:188-200
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
Urien L, Gaillard S, Lo Re L, Malapert P, Bohic M, Reynders A, Moqrich A
Scientific reports 2017 Feb 27;7:43493
Scientific reports 2017 Feb 27;7:43493
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA, Krasowska-Zoladek A, Nanda KK, Stachel SJ, Henze DA
Journal of neuroscience methods 2017 Apr 15;282:34-42
Journal of neuroscience methods 2017 Apr 15;282:34-42
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy.
Kue CS, Kamkaew A, Voon SH, Kiew LV, Chung LY, Burgess K, Lee HB
Scientific reports 2016 Nov 17;6:37209
Scientific reports 2016 Nov 17;6:37209
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.
Reed-Geaghan EG, Wright MC, See LA, Adelman PC, Lee KH, Koerber HR, Maricich SM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 13;36(15):4362-76
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 13;36(15):4362-76
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, Hjerling-Leffler J, Haeggström J, Kharchenko O, Kharchenko PV, Linnarsson S, Ernfors P
Nature neuroscience 2015 Jan;18(1):145-53
Nature neuroscience 2015 Jan;18(1):145-53
Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.
Oliveira Fernandes M, Tourtellotte WG
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 8;35(14):5566-78
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 8;35(14):5566-78
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.
Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L
BMC biology 2015 Apr 11;13:24
BMC biology 2015 Apr 11;13:24
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A
Nature communications 2014 Jun 5;5:4058
Nature communications 2014 Jun 5;5:4058
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes JP, Alonso S, Moqrich A
PLoS genetics 2014 Feb;10(2):e1004081
PLoS genetics 2014 Feb;10(2):e1004081
Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5399-410
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5399-410
Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P
The EMBO journal 2012 Sep 12;31(18):3718-29
The EMBO journal 2012 Sep 12;31(18):3718-29
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, Lewin GR, Willnow TE, Chao MV, Nykjaer A
Nature neuroscience 2011 Jan;14(1):54-61
Nature neuroscience 2011 Jan;14(1):54-61
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
Demel C, Hoegen T, Giese A, Angele B, Pfister HW, Koedel U, Klein M
Journal of neuroinflammation 2011 Jan 24;8(1):7
Journal of neuroinflammation 2011 Jan 24;8(1):7
Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.
Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB
PLoS biology 2011 Feb;9(2):e1001020
PLoS biology 2011 Feb;9(2):e1001020
Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons.
Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T
Molecular and cellular neurosciences 2010 Mar;43(3):296-307
Molecular and cellular neurosciences 2010 Mar;43(3):296-307
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.
Bouzas-Rodriguez J, Cabrera JR, Delloye-Bourgeois C, Ichim G, Delcros JG, Raquin MA, Rousseau R, Combaret V, Bénard J, Tauszig-Delamasure S, Mehlen P
The Journal of clinical investigation 2010 Mar;120(3):850-8
The Journal of clinical investigation 2010 Mar;120(3):850-8
Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy.
Kawamata T, Ninomiya T, Toriyabe M, Yamamoto J, Niiyama Y, Omote K, Namiki A
Neuroscience 2006 Nov 17;143(1):175-87
Neuroscience 2006 Nov 17;143(1):175-87
TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
Tamura S, Morikawa Y, Senba E
Neuroscience 2005;130(1):223-8
Neuroscience 2005;130(1):223-8
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Mouse and Rat TrkC by Western Blot. Western blot shows lysates of mouse brain (cerebellum) tissue, mouse brain (cortex) tissue, and rat brain tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for TrkC at approximately 100 and 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Mouse TrkC by Simple WesternTM. Simple Western lane view shows lysates of mouse brain tissue, loaded at 0.2 mg/mL. Specific bands were detected for TrkC at approximately 111 and 159 kDa (as indicated) using 25 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
