Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS1787 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1787, RRID:AB_1662086
- Product name
- PLC ÉÇ3 (L532) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 500-550 of Human PLC ÉÇ3.
- Description
- A total of eight mammalian PLC isozymes have been described (PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1 and PLC Ñ´2) with molecular weights ranging from 85 to 150 kDa. The ÎÛ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two ÎÛ-type enzymes, but not the ÉÇ and Ñ´ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC ÉÇ1, PLC ÉÇ2 and PLC ÉÇ3 is mediated by the Ï« subunits of the Gq class of heterotrimeric G proteins and by certain ÉÇÎÛ G protein subunits. The regulatory mechanisms for PLC Ñ´1 and PLC Ñ´2 are as yet not resolved.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of PLC ¦Â3 (L532) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate