CABT-B9193

antibody from Creative Diagnostics

Targeting: DAB2 DOC-2

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9193

Provider

Creative Diagnostics

Product name

Mouse anti-Mouse Disabled-2/p96 monoclonal antibody, clone 63/q07

Antibody type

Monoclonal

Description

CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2 (Dab-2) and as differentially expressed in ovarian carcinoma-2 (DOC-2). Dab-2/p96 has been shown to be essential for TGFÉÇ signaling by facilitating signal transduction from the TGFÉÇ receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

63/q07

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.