14155-1-AP

antibody from Proteintech Group

Targeting: FKBP5 FKBP51, FKBP54, P54, PPIase, Ptg-10

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

14155-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14155-1-AP, RRID:AB_2231625

Product name

FKBP5 antibody

Antibody type

Polyclonal

Description

KD/KO validated FKBP5 antibody (Cat. #14155-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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A transcriptomic microglia taxonomy across mouse and human pathologies.

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Nature immunology 2026 May;27(5):1066-1080

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Mechanisms by which sevoflurane affects cognitive function in aged marmosets and mice: up-regulation of FKBP5 expression in brain microglia.

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Medical gas research 2026 Mar 1;16(1):19-25

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European journal of psychotraumatology 2026 Dec;17(1):2619389

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Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function.

Liu C, Liu H, Li H, Yang D, Li Y, Wang R, Zhu J, Ma S, Guan S
PloS one 2025;20(7):e0313705

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FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation.

Li Z, Yin T, Guo H, Liu Z, Wang P, Liu C, Wang Q, Zhang M, Xiao Y, Wang J, Hao J, Zhang L
Frontiers in immunology 2025;16:1609989

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FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.

Chen L, Cui W, Qin J, Zhu M, Zhang H, Yang J, Xu Z, Huang H
Journal of integrative neuroscience 2025 Mar 19;24(3):25710

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Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway.

Zhu W, Cheng Y, Lang Z, Li W, Wei X
Journal of neuroscience research 2025 Jun;103(6):e70054

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FKBP5 promotes osteogenic differentiation of mesenchymal stem cells through type-I interferon pathway Inhibition.

Tang J, Li M, Chen Y, Liang Y, Yan W, Ning Q, Deng H, Liu H, Li Y, Huang L
Cellular and molecular life sciences : CMLS 2025 Jun 14;82(1):236

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De novo designed protein guiding targeted protein degradation.

Li Z, Qiao G, Wang X, Wang M, Cheng J, Hu G, Li X, Wu J, Liu J, Gao C, Liu L
Nature communications 2025 Jul 17;16(1):6598

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miR‑100‑5p and miR‑203a‑3p suppress esophageal squamous cell carcinoma progression by targeting FKBP5.

Tanaka H, Maruyama S, Shoda K, Kawaguchi Y, Higuchi Y, Ozawa T, Nakayama T, Saito R, Izumo W, Takiguchi K, Shiraishi K, Furuya S, Amemiya H, Kawaida H, Ichikawa D
Oncology reports 2025 Dec;54(6)

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AR Deficiency Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Macrophage M1 Polarization and Inflammatory Cytokine Secretion.

Wang X, Yin D, Sun J, Zhang L, Ye Y, Guo Q
Inflammation 2025 Dec;48(6):4203-4224

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Proteomic ratio reveals subtype-specific genetic mechanisms and therapeutic targets in osteoarthritis.

Wang Y, Yang X, Zhang Q, Che H, Liao L
Clinical proteomics 2025 Dec 5;23(1):1

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Inhibition of FKBP5 Alleviates Inflammation and Intestinal Barrier Dysfunction in Sepsis.

Li J, Apizi A, Song T, Kamilijiang P, Yu X, Chai R, Yu Z
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2025 Aug;45(8):290-299

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Xiaoyaosan alleviates chronic psychological stress-induced TH17/Treg imbalance via modulation of the FKBP5/NF-κB axis.

Zhang Y, Luo XR, Zhou YH, Xue QY, Wu SY, Xu JY, Li GH, Liu BP, Zhang MJ, Tong GD, Ao HQ, Liao MM
Journal of ethnopharmacology 2025 Aug 29;352:120184

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Baicalin alleviates lipid metabolism disorders in diabetic kidney disease via targeting FKBP51.

Li M, Zhu HY, Zhao SY, Li XD, Tong SM, Ma J, Xu AJ, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156473

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Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.

Chen G, Li X, Zhou X, Li Y, Yu H, Peng X, Bai X, Zhang C, Feng Z, Mei Y, Li L, Liu Y, Gou X, Jiang Y
Scientific reports 2024 Mar 20;14(1):6720

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Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats.

Guan F, Gao S, Sheng H, Ma Y, Chen W, Qi X, Zhang X, Gao X, Pang S, Zhang L, Zhang L
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Jul;253(7):659-676

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A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform.

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Lab on a chip 2023 Nov 7;23(22):4821-4833

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Kaempferol, a Phytoprogestin, Induces a Subset of Progesterone-Regulated Genes in the Uterus.

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Nutrients 2023 Mar 15;15(6)

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The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo.

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Blood-Based Epigenetic Markers of FKBP5 Gene Methylation in Patients With Dilated Cardiomyopathy.

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Journal of the American Heart Association 2021 Nov 2;10(21):e021101

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IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Oct;7(19):2001502

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Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.

Yamaguchi I, Nakajima K, Shono K, Mizobuchi Y, Fujihara T, Shikata E, Yamaguchi T, Kitazato K, Sampetrean O, Saya H, Takagi Y
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Elective caesarean delivery and offspring's cognitive impairment: Implications of methylation alteration in hippocampus glucocorticoid signaling genes.

Huang K, Hu Y, Sun Y, Yu Z, Liu W, Zhu P, Tao F
Brain research bulletin 2019 Jan;144:108-121

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Kurek A, Głombik K, Detka J, Basta-Kaim A, Kubera M, Lasoń W, Budziszewska B
Journal of neuroendocrinology 2018 Mar 9;

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A severe mouse model of spinal muscular atrophy develops early systemic inflammation.

Wan B, Feng P, Guan Z, Sheng L, Liu Z, Hua Y
Human molecular genetics 2018 Dec 1;27(23):4061-4076

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USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

Luo K, Li Y, Yin Y, Li L, Wu C, Chen Y, Nowsheen S, Hu Q, Zhang L, Lou Z, Yuan J
The EMBO journal 2017 May 15;36(10):1434-1446

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The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI
RNA (New York, N.Y.) 2013 Nov;19(11):1583-93

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Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

K-562 cells were subjected to SDS PAGE followed by western blot with 14155-1-AP(FKBP5 antibody) at dilution of 1:1000

Sample type

cell line

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-FKBP5 (IP:14155-1-AP, 3ug; Detection:14155-1-AP 1:1000) with K-562 cells lysate 1500ug.

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 14155-1-AP(FKBP5 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The FKBP5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FKBP5. This antibody recognizes human,mouse,rat antigen. The FKBP5 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.

Appendix

14155-1-AP.pdf

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