Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9208 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Mouse FKBP51 monoclonal antibody, clone 29/GLCQ62
- Antibody type
- Monoclonal
- Description
- FK506, one of several potent compounds that block T cell proliferation, is used in immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets of FK506. These proteins include FKBP12, FKBP12.6, and FKBP52. The immunosuppressive effects of FK506 and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. Calcineurin and FKBP's are widely distributed, therefore, it is difficult to achieve immunosuppressive specificity by FK506. FKBP51 (51kDa) is an FK506-binding protein that is expressed exclusively in T cells and has homology to FKBP52. Because of its limited distribution, FKBP51 may provide a more selective target for FK506 in T cells.
- Reactivity
- Human, Mouse, Rat, Chicken/Avian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 29/GLCQ62
- Vial size
- 50 _g
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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