CABT-B9208

antibody from Creative Diagnostics
Targeting: FKBP5 FKBP51, FKBP54, P54, PPIase, Ptg-10
Provider product page for CABT-B9208
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
CABT-B9208 - Provider product page
Provider
Creative Diagnostics
Product name
Mouse anti-Mouse FKBP51 monoclonal antibody, clone 29/GLCQ62
Antibody type
Monoclonal
Description
FK506, one of several potent compounds that block T cell proliferation, is used in immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets of FK506. These proteins include FKBP12, FKBP12.6, and FKBP52. The immunosuppressive effects of FK506 and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. Calcineurin and FKBP's are widely distributed, therefore, it is difficult to achieve immunosuppressive specificity by FK506. FKBP51 (51kDa) is an FK506-binding protein that is expressed exclusively in T cells and has homology to FKBP52. Because of its limited distribution, FKBP51 may provide a more selective target for FK506 in T cells.
Reactivity
Human, Mouse, Rat, Chicken/Avian
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
29/GLCQ62
Vial size
50 _g
Concentration
250 Ã×g/ml
Storage
Store undiluted at -20°C.
FKBP5 protein structure - CABT-B9208 shown in red.