BS2547
antibody from Bioworld Technology, Inc
Targeting: BLNK
BASH, bca, BLNK-s, Ly57, SLP-65, SLP65
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- BS2547 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BLNK (N91) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 60-107 of Human BLNK.
- Description
- B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-°ÙB. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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