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- Antibody Data
- Antigen structure
- References [35]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16290-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16290-1-AP, RRID:AB_2151832
- Product name
- ARC/ARG3.1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ARC/ARG3.1 antibody (Cat. #16290-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement.
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Arc Capsids Facilitate the Transfer of Muscleblind.
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Cerebellar microglia-derived IL-17A mitigates autism-related behavioral and synaptic deficits.
FoxO3a regulated by miR-150-5p promotes the pyroptosis of macrophages in atherosclerosis.
C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis.
Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression.
The inner ear is a barometric pressure sensor-change in barometric pressure induces vestibular ganglion cell activation in mice.
dArc1 controls sugar reward valuation in Drosophila melanogaster.
Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.
An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.
Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice.
Automated Segmentation of the Mouse Body Language to Study Stimulus-Evoked Emotional Behaviors.
Nicotine, THC, and Dolutegravir Modulate E-Cigarette-Induced Changes in Addiction- and Inflammation-Associated Genes in Rat Brains and Astrocytes.
ARC/Arg3.1 expression in the lateral geniculate body of monocular form deprivation amblyopic kittens.
Lactate Mediates High-Intensity Interval Training-Induced Promotion of Hippocampal Mitochondrial Function through the GPR81-ERK1/2 Pathway.
Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice.
Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity.
Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.
EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment.
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Dynamic Changes of Cytoskeleton-Related Proteins Within Reward-Related Brain Regions in Morphine-Associated Memory.
Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice.
Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.
Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis.
Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome.
Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease.
Bian X, Shang Q, Zhu L, Liu J, Wu M, Li J, Lou S
Frontiers in cell and developmental biology 2026;14:1699042
Frontiers in cell and developmental biology 2026;14:1699042
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423
Aging cell 2026 Mar;25(3):e70423
Arc Capsids Facilitate the Transfer of Muscleblind.
Zinter M, Xiao C, M'Angale PG, Zhao-Shea R, Freels T, Tapper A, Thomson T
bioRxiv : the preprint server for biology 2026 Mar 10;
bioRxiv : the preprint server for biology 2026 Mar 10;
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Cheng H, Gao Y, Shang H, Han W, Zhang X, Gao R, Dang W, Ma Z, Liu X, Gao Y
Scientific reports 2026 Jan 5;16(1):1091
Scientific reports 2026 Jan 5;16(1):1091
Cerebellar microglia-derived IL-17A mitigates autism-related behavioral and synaptic deficits.
Yin J, Li W, Shen LP, Zhang WL, Chen JY, Zhang BB, Chen YJ, Li T, Li HZ, Gao Z, Xie ST, Zhang QP, Zhang C, Zhang XY, Zhu JN
Molecular psychiatry 2026 Feb 9;
Molecular psychiatry 2026 Feb 9;
FoxO3a regulated by miR-150-5p promotes the pyroptosis of macrophages in atherosclerosis.
Cai PY, Li MM, Chen SH, Zheng YL, Li J, Huang DH, Du JR, Lin HL
PloS one 2025;20(10):e0327075
PloS one 2025;20(10):e0327075
C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis.
Jiang R, Chouchane M, Chen KS, Moey C, Bunt J, Li J, Alkuraya F, Alobeid E, Richards L, Ullian E, Sherr E
bioRxiv : the preprint server for biology 2025 Mar 14;
bioRxiv : the preprint server for biology 2025 Mar 14;
Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression.
Kolasa M, Nikiforuk A, Korlatowicz A, Solich J, Potasiewicz A, Dziedzicka-Wasylewska M, Bugno R, Hogendorf A, Bojarski A, Faron-Górecka A
Psychopharmacology 2025 Jul;242(7):1607-1625
Psychopharmacology 2025 Jul;242(7):1607-1625
The inner ear is a barometric pressure sensor-change in barometric pressure induces vestibular ganglion cell activation in mice.
Sato J, Inagaki H, Kusui M, Yokosuka M, Ushida T
Scientific reports 2025 Dec 24;15(1):44525
Scientific reports 2025 Dec 24;15(1):44525
dArc1 controls sugar reward valuation in Drosophila melanogaster.
Bervoets S, Jacob MS, Devineni AV, Mahoney BD, Sullivan KR, Butts AR, Sung H, Einstein J, Metzstein MM, Dus M, Shepherd JD, Caron SJC
bioRxiv : the preprint server for biology 2024 Nov 8;
bioRxiv : the preprint server for biology 2024 Nov 8;
Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.
Chelini G, Mirzapourdelavar H, Durning P, Baidoe-Ansah D, Sethi MK, O'Donovan SM, Klengel T, Balasco L, Berciu C, Boyer-Boiteau A, McCullumsmith R, Ressler KJ, Zaia J, Bozzi Y, Dityatev A, Berretta S
Cell reports 2024 May 28;43(5):114112
Cell reports 2024 May 28;43(5):114112
An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.
Maino E, Scott O, Rizvi SZ, Chan WS, Visuvanathan S, Zablah YB, Li H, Sengar AS, Salter MW, Jia Z, Rossant J, Cohn RD, Gu B, Ivakine EA
Disease models & mechanisms 2024 Jul 1;17(7)
Disease models & mechanisms 2024 Jul 1;17(7)
Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice.
Deng L, Jiang H, Lin J, Xu D, Qi A, Guo Q, Li PP, Wang X, Liu JS, Fu X, Li P
Neurobiology of disease 2024 Apr;193:106457
Neurobiology of disease 2024 Apr;193:106457
Automated Segmentation of the Mouse Body Language to Study Stimulus-Evoked Emotional Behaviors.
Chelini G, Trombetta EM, Fortunato-Asquini T, Ollari O, Pecchia T, Bozzi Y
eNeuro 2023 Sep;10(9)
eNeuro 2023 Sep;10(9)
Nicotine, THC, and Dolutegravir Modulate E-Cigarette-Induced Changes in Addiction- and Inflammation-Associated Genes in Rat Brains and Astrocytes.
Kulbe JR, Nguyen L, Le AA, Laird AE, Taffe MA, Nguyen JD, Fields JA
Brain sciences 2023 Nov 7;13(11)
Brain sciences 2023 Nov 7;13(11)
ARC/Arg3.1 expression in the lateral geniculate body of monocular form deprivation amblyopic kittens.
Fan H, Wang Y, Zou Y, Song W, Xie J, Tang X, Chen S
BMC ophthalmology 2023 Jan 3;23(1):3
BMC ophthalmology 2023 Jan 3;23(1):3
Lactate Mediates High-Intensity Interval Training-Induced Promotion of Hippocampal Mitochondrial Function through the GPR81-ERK1/2 Pathway.
Shang Q, Bian X, Zhu L, Liu J, Wu M, Lou S
Antioxidants (Basel, Switzerland) 2023 Dec 7;12(12)
Antioxidants (Basel, Switzerland) 2023 Dec 7;12(12)
Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice.
Zhang ZZ, Zeng LP, Chen J, Wu YF, Wang YT, Xia L, Yang QG, Wang F, Chen GH
Neural plasticity 2022;2022:1483101
Neural plasticity 2022;2022:1483101
Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.
Qiu Y, Sha L, Zhang X, Li G, Zhu W, Xu Q
Frontiers in aging neuroscience 2022;14:896522
Frontiers in aging neuroscience 2022;14:896522
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Zhao L, Jiang H, Xie J, Shen D, Yi Q, Yan J, Li C, Zheng H, Gao H
Molecular neurobiology 2022 Sep;59(9):5656-5672
Molecular neurobiology 2022 Sep;59(9):5656-5672
Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.
Zhang Y, Bai X, Zhang Y, Yao S, Cui Y, You LH, Yu P, Chang YZ, Gao G
Molecular neurobiology 2022 Sep;59(9):5574-5590
Molecular neurobiology 2022 Sep;59(9):5574-5590
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.
Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ
Neurobiology of disease 2022 Oct 1;172:105834
Neurobiology of disease 2022 Oct 1;172:105834
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity.
Xu C, Zhang M, Zu L, Zhang P, Sun L, Liu X, Fang M
Aging 2021 Jun 9;13(11):15569-15579
Aging 2021 Jun 9;13(11):15569-15579
Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.
Ishikawa S, Nishida N, Fujino S, Ogino T, Takahashi H, Miyoshi N, Uemura M, Satoh T, Yamamoto H, Mizushima T, Doki Y, Eguchi H
Scientific reports 2021 Jun 3;11(1):11759
Scientific reports 2021 Jun 3;11(1):11759
EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment.
Yao ZH, Wang J, Yuan JP, Xiao K, Zhang SF, Xie YC, Mei JH
Aging 2021 Feb 3;13(7):9522-9541
Aging 2021 Feb 3;13(7):9522-9541
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Shen Y, Zhang ZC, Cheng S, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J
Molecular cell 2021 Apr 1;81(7):1425-1438.e10
Molecular cell 2021 Apr 1;81(7):1425-1438.e10
Dynamic Changes of Cytoskeleton-Related Proteins Within Reward-Related Brain Regions in Morphine-Associated Memory.
Yang X, Wen Y, Zhang Y, Gao F, Yang J, Yang Z, Yan C
Frontiers in neuroscience 2020;14:626348
Frontiers in neuroscience 2020;14:626348
Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice.
Zhang ZZ, Zhuang ZQ, Sun SY, Ge HH, Wu YF, Cao L, Xia L, Yang QG, Wang F, Chen GH
Frontiers in aging neuroscience 2020;12:157
Frontiers in aging neuroscience 2020;12:157
Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.
Jenks KR, Shepherd JD
Cell reports 2020 Feb 11;30(6):1982-1994.e4
Cell reports 2020 Feb 11;30(6):1982-1994.e4
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.
Acuña-Hinrichsen F, Muñoz M, Hott M, Martin C, Mancilla E, Salazar P, Leyton L, Zambrano A, Concha MI, Burgos PV, Otth C
Frontiers in cellular neuroscience 2018;12:505
Frontiers in cellular neuroscience 2018;12:505
Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis.
Haque MN, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:164-175
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:164-175
Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome.
Pastuzyn ED, Shepherd JD
Frontiers in molecular neuroscience 2017;10:234
Frontiers in molecular neuroscience 2017;10:234
Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.
Casimiro TM, Nawy S, Carroll RC
Molecular and cellular neurosciences 2013 Sep;56:384-92
Molecular and cellular neurosciences 2013 Sep;56:384-92
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease.
Yao J, Chen S, Mao Z, Cadenas E, Brinton RD
PloS one 2011;6(7):e21788
PloS one 2011;6(7):e21788
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 16290-1-AP(ARC antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16290-1-AP(ARC antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ARC/ARG3.1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ARC/ARG3.1. This antibody recognizes human,mouse,rat antigen. The ARC/ARG3.1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
