13584-1-AP

antibody from Proteintech Group

Targeting: YAP1 YAP65

Provider product page for 13584-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [105]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

Submit

Product number: 13584-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13584-1-AP, RRID:AB_2218915
Product name: YAP1 antibody
Antibody type: Polyclonal
Description: KD/KO validated YAP1 antibody (Cat. #13584-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YAP1 protein structure - 13584-1-AP shown in red.

Submitted references Electrochemically derived nanographene oxide activates endothelial tip cells and promotes angiogenesis by binding endogenous lysophosphatidic acid.

Liu W, Luo H, Wei Q, Liu J, Wu J, Zhang Y, Chen L, Ren W, Shao L
Bioactive materials 2022 Mar;9:92-104

SOX13/TRIM11/YAP axis promotes the proliferation, migration and chemoresistance of anaplastic thyroid cancer.

Tang J, Tian Z, Liao X, Wu G
International journal of biological sciences 2021;17(2):417-429

PADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles.

Huang B, Zhao Y, Zhou L, Gong T, Feng J, Han P, Qian J
Journal of inflammation research 2021;14:3489-3500

Expression and Functional Relevance of ANXA1 in Hypopharyngeal Carcinoma with Lymph Node Metastasis.

Li L, Wang Z, Lu T, Li Y, Pan M, Yu D, Hu G
OncoTargets and therapy 2021;14:1387-1399

Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis.

Morice S, Danieau G, Tesfaye R, Mullard M, Brion R, Dupuy M, Ory B, Brounais-Le Royer B, Corre I, Redini F, Verrecchia F
Frontiers in oncology 2021;11:765711

Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.

Zhao W, Zhang X, Hou M, Zhang Y, Tang Y, Li L, Dong S, Liu L, Zhao D, Li W, Nan Y
Histology and histopathology 2021 Sep;36(9):967-979

PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy.

Guo Y, Cang X, Zhu L, Zhu M, Li A, Wang Z, Zhang Y, Wang X, Song E
Experimental eye research 2021 Sep;210:108703

MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.

Mao Y, Jiang L
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30

Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway.

Nong S, Wei Z, Wang Z, Ma L, Guan Y, Ni J
Stem cells and development 2021 Sep 15;30(18):934-945

SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.

Ren D, Sun Y, Zhang D, Li D, Liu Z, Jin X, Wu H
Cancer letters 2021 Oct 28;519:277-288

Identification of YAP1 as a novel downstream effector of the FGF2/STAT3 pathway in the pathogenesis of renal tubulointerstitial fibrosis.

Li X, Zhang F, Qu L, Xie Y, Ruan Y, Guo Z, Mao Y, Zou Q, Shi M, Xiao Y, Wang Y, Zhou Y, Guo B
Journal of cellular physiology 2021 Nov;236(11):7655-7671

Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling.

Brielle S, Bavli D, Motzik A, Kan-Tor Y, Sun X, Kozulin C, Avni B, Ram O, Buxboim A
Proceedings of the National Academy of Sciences of the United States of America 2021 May 11;118(19)

Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer.

Su W, Zhu S, Chen K, Yang H, Tian M, Fu Q, Shi G, Feng S, Ren D, Jin X, Yang C
Journal of experimental & clinical cancer research : CR 2021 Mar 1;40(1):88

Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway.

Ma WY, Song RJ, Xu BB, Xu Y, Wang XX, Sun HY, Li SN, Liu SZ, Yu MX, Yang F, Ye DY, Gong R, Han ZB, Yu Y, Bamba D, Wang N, Pan ZW, Cai BZ
Acta pharmacologica Sinica 2021 Jun;42(6):921-931

Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma.

Guo C, Zhou S, Yi W, Yang P, Li O, Liu J, Peng C
Experimental and molecular pathology 2021 Jun;120:104638

Importance of Potential New Biomarkers in Patient with Serouse Ovarian Cancer.

Cymbaluk-Płoska A, Chudecka K, Chudecka-Głaz A, Piotrowska K, Kwiatkowski S, Tarnowski M
Diagnostics (Basel, Switzerland) 2021 Jun 3;11(6)

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development.

Pocaterra A, Scattolin G, Romani P, Ament C, Ribback S, Chen X, Evert M, Calvisi DF, Dupont S
Communications biology 2021 Jun 21;4(1):763

MINDY1 promotes bladder cancer progression by stabilizing YAP.

Luo Y, Zhou J, Tang J, Zhou F, He Z, Liu T, Liu T
Cancer cell international 2021 Jul 27;21(1):395

Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer.

Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H
Science advances 2021 Jan;7(5)

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.

Cui R, Jiang N, Zhang M, Du S, Ou H, Ge R, Ma D, Zhang J
Biochimica et biophysica acta. Molecular cell research 2021 Jan;1868(1):118858

S1P induces proliferation of pulmonary artery smooth muscle cells by promoting YAP-induced Notch3 expression and activation.

Wang J, Yan X, Feng W, Wang Q, Shi W, Chai L, Zhang Q, Chen Y, Liu J, Qu Z, Xie X, Li M
The Journal of biological chemistry 2021 Jan-Jun;296:100599

Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.

Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022

Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.

Xu G, Seng Z, Zhang M, Qu J
Environmental toxicology 2021 Dec;36(12):2500-2511

Loss of m⁶A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.

Gong R, Wang X, Li H, Liu S, Jiang Z, Zhao Y, Yu Y, Han Z, Yu Y, Dong C, Li S, Xu B, Zhang W, Wang N, Li X, Gao X, Yang F, Bamba D, Ma W, Liu Y, Cai B
Pharmacological research 2021 Dec;174:105845

Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis.

Ma G, Chen J, Wei T, Wang J, Chen W
Cytotechnology 2021 Aug;73(4):523-537

Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation by regulation of β-catenin and YAP pathways.

Li Y, Yan J, Wang M, Lv J, Yan F, Chen J
Journal of molecular histology 2021 Apr;52(2):197-205

Circ-ITCH sponges miR-214 to promote the osteogenic differentiation in osteoporosis via upregulating YAP1.

Zhong D, Xu GZ, Wu JZ, Liu H, Tang JY, Wang CG
Cell death & disease 2021 Apr 1;12(4):340

Retinal dehydrogenase 5 (RHD5) attenuates metastasis via regulating HIPPO/YAP signaling pathway in Hepatocellular Carcinoma.

Hu H, Xu L, Luo SJ, Xiang T, Chen Y, Cao ZR, Zhang YJ, Mo Z, Wang Y, Meng DF, Yu L, Lin LZ, Zhang SJ
International journal of medical sciences 2020;17(13):1897-1908

Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis.

Wang X, Wang G, Qu J, Yuan Z, Pan R, Li K
Frontiers in pharmacology 2020;11:200

CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.

Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034

CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.

Chen L, Long X, Duan S, Liu X, Chen J, Lan J, Liu X, Huang W, Geng J, Zhou J
Theranostics 2020;10(24):11063-11079

FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.

Zheng YW, Li ZH, Lei L, Liu CC, Wang Z, Fei LR, Yang MQ, Huang WJ, Xu HT
Frontiers in oncology 2020;10:180

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120

Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.

Feldker N, Ferrazzi F, Schuhwerk H, Widholz SA, Guenther K, Frisch I, Jakob K, Kleemann J, Riegel D, Bönisch U, Lukassen S, Eccles RL, Schmidl C, Stemmler MP, Brabletz T, Brabletz S
The EMBO journal 2020 Sep 1;39(17):e103209

MiR-375-3p alleviates the severity of inflammation through targeting YAP1/LEKTI pathway in HaCaT cells.

Cheng S, Di Z, Hirman AR, Zheng H, Duo L, Zhai Q, Xu J
Bioscience, biotechnology, and biochemistry 2020 Oct;84(10):2005-2013

Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.

Lin BY, Wen JL, Zheng C, Lin LZ, Chen CZ, Qu JM
Journal of cellular and molecular medicine 2020 Nov;24(22):13070-13080

Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.

Yang Y, Liu X, Zheng J, Xue Y, Liu L, Ma J, Wang P, Yang C, Wang D, Shao L, Ruan X, Liu Y
Molecular oncology 2020 Nov;14(11):2936-2959

Vitamin D3 analogue facilitates epithelial wound healing through promoting epithelial-mesenchymal transition via the Hippo pathway.

Wang D, Lin L, Lei K, Zeng J, Luo J, Yin Y, Li Y, Zhang L, Nie X, Zuo D, Sun L
Journal of dermatological science 2020 Nov;100(2):120-128

MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.

Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250

Gut microbiota transplantation from db/db mice induces diabetes-like phenotypes and alterations in Hippo signaling in pseudo germ-free mice.

Yu F, Jiang R, Han W, Zhan G, Xu X, Jiang X, Wang L, Xiang S, Zhou Q, Liu C, Zhu B, Hua F, Yang C
Aging 2020 Nov 20;12(23):24156-24167

Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma.

Zhou X, Chen N, Xu H, Zhou X, Wang J, Fang X, Zhang Y, Li Y, Yang J, Wang X
Journal of hematology & oncology 2020 Jun 16;13(1):77

Targeting LncDACH1 promotes cardiac repair and regeneration after myocardium infarction.

Cai B, Ma W, Wang X, Sukhareva N, Hua B, Zhang L, Xu J, Li X, Li S, Liu S, Yu M, Xu Y, Song R, Xu B, Yang F, Han Z, Ding F, Huang Q, Yu Y, Zhao Y, Wang J, Bamba D, Zagidullin N, Li F, Tian Y, Pan Z, Yang B
Cell death and differentiation 2020 Jul;27(7):2158-2175

Effect of Maternal Age on Hippo Pathway Related Gene Expressions and Protein Localization Pattern in Human Embryos.

Gharanfoli S, Shahverdi A, Dalman A, Ghaznavi P, Alipour H, Eftekhari-Yazdi P
Cell journal 2020 Jul;22(Suppl 1):74-80

gga-microRNA-375 negatively regulates the cell cycle and proliferation by targeting Yes-associated protein 1 in DF-1 cells.

Zhang X, Liao Z, Wu Y, Yan Y, Chen S, Lin S, Chen F, Xie Q
Experimental and therapeutic medicine 2020 Jul;20(1):530-542

MALAT1 knockdown inhibits hypopharyngeal squamous cell carcinoma malignancy by targeting microRNA-194.

Wang H, Wang F, Ouyang W, Jiang X, Li W
Oncology letters 2020 Jul;20(1):173-182

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.

Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S
Nature materials 2020 Jul;19(7):797-806

PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.

Yu W, Hua Y, Qiu H, Hao J, Zou K, Li Z, Hu S, Guo P, Chen M, Sui S, Xiong Y, Li F, Lu J, Guo W, Luo G, Deng W
Cell death & disease 2020 Jul 6;11(7):506

Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.

Zheng Y, Nie P, Xu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628

Retinal blood vessel-origin yes-associated protein (YAP) governs astrocytic maturation via leukaemia inhibitory factor (LIF).

Ai LQ, Yuan RD, Chen X, Liu YJ, Liu WY, Zhu JY, Zhang Z, Yan J, Chen CL, Lin S, Ye J
Cell proliferation 2020 Feb;53(2):e12757

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing.

Chen X, Xu M, Xu X, Zeng K, Liu X, Sun L, Pan B, He B, Pan Y, Sun H, Xia X, Wang S
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):599-612

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

Wei L, Cao P, Xu C, Zhong H, Wang X, Bai M, Hu B, Wang R, Liu N, Tian Y, Chen H, Li J, Yuan W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16581-16600

Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

Miao X, Zhang N
Experimental and molecular pathology 2020 Dec;117:104546

Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy.

Zhou W, Liu M, Li X, Zhang P, Li J, Zhao Y, Sun G, Mao W
Cell & bioscience 2020 Dec 22;10(1):146

The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth.

Morice S, Mullard M, Brion R, Dupuy M, Renault S, Tesfaye R, Brounais-Le Royer B, Ory B, Redini F, Verrecchia F
Cancers 2020 Dec 20;12(12)

Mechanisms of stretch-mediated skin expansion at single-cell resolution.

Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons BD, Blanpain C
Nature 2020 Aug;584(7820):268-273

TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

Zhou S, Liu S, Lin C, Li Y, Ye L, Wu X, Jian Y, Dai Y, Ouyang Y, Zhao L, Liu M, Song L, Xi M
Oncogene 2020 Apr;39(18):3710-3725

Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.

An SY, Gao XX, Wang ZB, Liang YX, Wang ST, Xiao SH, Xia JT, You PH, Wang F, Zhang GM
Animal reproduction science 2020 Apr;215:106328

miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway.

Wu T, Hu H, Zhang T, Jiang L, Li X, Liu S, Zheng C, Yan G, Chen W, Ning Y, Li Y, Lu Z
Oxidative medicine and cellular longevity 2019;2019:9719723

Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway.

Yuan L, Zhou M, Wasan HS, Zhang K, Li Z, Guo K, Shen F, Shen M, Ruan S
Evidence-based complementary and alternative medicine : eCAM 2019;2019:1431726

Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1.

Wang J, Li H, Xia C, Yang X, Dai B, Tao K, Dou K
OncoTargets and therapy 2019;12:869-882

Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1.

Liu K, Du S, Gao P, Zheng J
Journal of Cancer 2019;10(18):4196-4207

Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells.

He L, Wu MZ, Wang XB, Qiu XS, Wang EH, Wu GP
Journal of Cancer 2019;10(16):3632-3638

Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway.

Zhang Y, Xin C, Qiu J, Wang Z
Molecules (Basel, Switzerland) 2019 Oct 25;24(21)

Differential Levels of Hippo Signaling in Selected Brain and Peripheral Tissues in Streptozotocin-Induced Cognitive Dysfunction in Mice.

Yu F, Han W, Zhan G, Li S, Jiang X, Xiang S, Zhu B, Yang L, Hua D, Luo A, Hua F, Yang C
Neuroscience 2019 Nov 21;421:48-58

F-actin dynamics regulates mammalian organ growth and cell fate maintenance.

Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, Carnicer-Lombarte A, Forcato M, Braghetta P, Montagner M, Galuppini F, Aragona M, Pennelli G, Bicciato S, Gauthier N, Franze K, Dupont S
Journal of hepatology 2019 Jul;71(1):130-142

LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a.

Sun J, Su W, Zhao X, Shan T, Jin T, Guo Y, Li C, Li R, Zhou Y, Shan H, Sun X, Liang H
Bioscience reports 2019 Jul 31;39(7)

Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition.

Zhang X, Yan Y, Lin W, Li A, Zhang H, Lei X, Dai Z, Li X, Li H, Chen W, Chen F, Ma J, Xie Q
RNA biology 2019 Jan;16(1):118-132

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae.

Rausch V, Bostrom JR, Park J, Bravo IR, Feng Y, Hay DC, Link BA, Hansen CG
Current biology : CB 2019 Jan 21;29(2):242-255.e6

Fufang Xueshuantong protects retinal vascular endothelial cells from high glucose by targeting YAP.

Xing W, Song Y, Li H, Wang Z, Wu Y, Li C, Wang Y, Liu Y, Wang W, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109470

Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.

Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915

CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.

Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J
Cell death & disease 2019 Dec 11;10(12):949

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)

LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway.

Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(4):1578-1588

lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis.

Zhao X, Sun J, Chen Y, Su W, Shan H, Li Y, Wang Y, Zheng N, Shan H, Liang H
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Sep 5;26(9):2206-2217

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.

Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S
Nature medicine 2018 Oct;24(10):1599-1610

Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.

Yang R, Cai TT, Wu XJ, Liu YN, He J, Zhang XS, Ma G, Li J
Immunology 2018 Oct;155(2):263-272

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.

Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S
Nature 2018 Nov;563(7730):265-269

Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.

Mana-Capelli S, McCollum D
The Journal of biological chemistry 2018 Nov 23;293(47):18230-18241

The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition.

Shi J, Li F, Yao X, Mou T, Xu Z, Han Z, Chen S, Li W, Yu J, Qi X, Liu H, Li G
Oncogene 2018 May;37(22):3022-3038

REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.

Chen S, Wang Q, Wang L, Chen H, Gao X, Gong D, Ma J, Kubra S, Yao X, Li X, Li L, Zhai W, Zheng J
Cell death & disease 2018 May 24;9(6):627

YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD.

Yu M, Chen Y, Li X, Yang R, Zhang L, Huangfu L, Zheng N, Zhao X, Lv L, Hong Y, Liang H, Shan H
Cell death & disease 2018 May 1;9(5):464

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.

Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J
Scientific reports 2018 Jun 12;8(1):8981

ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.

Yu P, Shen X, Yang W, Zhang Y, Liu C, Huang T
Biochemical and biophysical research communications 2018 Jan 22;495(4):2505-2511

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer.

Yu SJ, Yang L, Hong Q, Kuang XY, Di GH, Shao ZM
BMC cancer 2018 Jan 12;18(1):74

Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling.

Kaylan KB, Berg IC, Biehl MJ, Brougham-Cook A, Jain I, Jamil SM, Sargeant LH, Cornell NJ, Raetzman LT, Underhill GH
eLife 2018 Dec 27;7

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.

Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, Shabanova A, Shan H, Liang H
International journal of molecular sciences 2018 Apr 9;19(4)

MiR-361 targets Yes-associated protein (YAP) mRNA to suppress cell proliferation in lung cancer.

Zhang S, Liu Z, Wu L, Wang Y
Biochemical and biophysical research communications 2017 Oct 21;492(3):468-473

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling.

Serafimidis I, Rodriguez-Aznar E, Lesche M, Yoshioka K, Takuwa Y, Dahl A, Pan D, Gavalas A
PLoS biology 2017 Mar;15(3):e2000949

MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma.

Fan YP, Liao JZ, Lu YQ, Tian DA, Ye F, Zhao PX, Xiang GY, Tang WX, He XX
Molecular therapy. Nucleic acids 2017 Jun 16;7:181-189

The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer.

Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, Liu B, Zhang X, Ye L
Cancer letters 2017 Jan 28;385:234-242

Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.

Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, Wang R
Oncotarget 2017 Dec 12;8(65):109301-109318

E-Cadherin-Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis.

Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z
The Journal of investigative dermatology 2017 Aug;137(8):1731-1739

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.

Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, Herr R, Brabletz S, Stemmler MP, Brabletz T
Nature communications 2016 Feb 15;7:10498

Paper-based microreactor array for rapid screening of cell signaling cascades.

Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X, Ye L
Oncogene 2016 Aug 4;35(31):4048-57

Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.

Sun T, Pepling ME, Diaz FJ
Biology of reproduction 2015 Jul;93(1):22

A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level.

Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye L, Zhang X
Biochemical and biophysical research communications 2015 Apr 3;459(2):306-312

Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC).

Zhao Y, Zhou W, Xue L, Zhang W, Zhan Q
PloS one 2014;9(3):e90836

MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.

Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH
Acta pharmacologica Sinica 2014 Sep;35(9):1207-14

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.

Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, Zhang X, Zhang F, Chen H, Liu Y, Jiang Y, Sun S, Zheng Y, Li N, Huang L
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 7;111(1):E89-98

Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio).

Hu J, Sun S, Jiang Q, Sun S, Wang W, Gui Y, Song H
International journal of biological sciences 2013;9(3):267-78

MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer.

Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, Wu J, Shen ZZ, Song HY, Shao ZM
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 15;19(6):1389-99

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.

Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Wang Y, Yang X, Ye L, Zhang X
Hepatology (Baltimore, Md.) 2012 Dec;56(6):2051-9

Hippo signaling regulates pancreas development through inactivation of Yap.

George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE
Molecular and cellular biology 2012 Dec;32(24):5116-28

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 13584-1-AP(YAP1 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells using 13584-1-AP( YAP1 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human ovary tumor using 13584-1-AP(YAP1 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue