Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- orb154318 - Provider product page
- Provider
- Biorbyt
- Product name
- YAP antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody to YAP. The transcriptional coactivator Yes-associated protein (YAP) has been shown to interact with and to enhance p73-dependent apoptosis in response to DNA damage. It has been shown that YAP requires the promyelocytic leukemia gene (PML) and nuclear body localization to coactivate p73. YAP imparts selectivity to p73 by promoting the activation of a subset of p53 and/or p73 target promoters (1). Akt promotes YAP localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. p73-mediated induction of Bax expression following DNA damage requires YAP function and is attenuated by Akt phosphorylation of YAP. YAP overexpression increases, while YAP depletion decreases, p73-mediated apoptosis following DNA damage, in an Akt inhibitable manner
- Reactivity
- Human, Mouse, Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 ul
- Storage
- Store at -20°C. Avoid freeze / thaw cycles.
No comments: Submit comment
No validations: Submit validation data