orb154318

antibody from Biorbyt
Targeting: YAP1 YAP65
Provider product page for orb154318
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
orb154318 - Provider product page
Provider
Biorbyt
Product name
YAP antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal antibody to YAP. The transcriptional coactivator Yes-associated protein (YAP) has been shown to interact with and to enhance p73-dependent apoptosis in response to DNA damage. It has been shown that YAP requires the promyelocytic leukemia gene (PML) and nuclear body localization to coactivate p73. YAP imparts selectivity to p73 by promoting the activation of a subset of p53 and/or p73 target promoters (1). Akt promotes YAP localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. p73-mediated induction of Bax expression following DNA damage requires YAP function and is attenuated by Akt phosphorylation of YAP. YAP overexpression increases, while YAP depletion decreases, p73-mediated apoptosis following DNA damage, in an Akt inhibitable manner
Reactivity
Human, Mouse, Rat
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 ul
Storage
Store at -20°C. Avoid freeze / thaw cycles.
YAP1 protein structure - orb154318 shown in red.