Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- P00116 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Phospho-YAP1 (S127) Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for YAP/YAP1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC, WB. Reactive species: Human, Mouse, Rat YAP/YAP1 information: Molecular Weight: 54462 MW; Subcellular Localization: Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271); Tissue Specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antibody clone number
- GAB-25
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- At -20°C for one year. Avoid repeated freezing and thawing.
Submitted references Dapagliflozin delays renal fibrosis in diabetic kidney disease by inhibiting YAP/TAZ activation.
YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR.
Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
PMMA Bone Cement Acts on the Hippo/YAP Pathway To Regulate CTGF and Induce Intervertebral Disc Degeneration.
Feng L, Chen Y, Li N, Yang X, Zhou L, Li H, Wang T, Xie M, Liu H
Life sciences 2023 Jun 1;322:121671
Life sciences 2023 Jun 1;322:121671
YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR.
Pan X, Wu B, Fan X, Xu G, Ou C, Chen M
Journal of cellular and molecular medicine 2021 Jan;25(1):170-183
Journal of cellular and molecular medicine 2021 Jan;25(1):170-183
Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
Zhang Q, Cao Y, Liu Y, Huang W, Ren J, Wang P, Song C, Fan K, Ba L, Wang L, Sun H
Biochemical pharmacology 2021 Apr;186:114466
Biochemical pharmacology 2021 Apr;186:114466
PMMA Bone Cement Acts on the Hippo/YAP Pathway To Regulate CTGF and Induce Intervertebral Disc Degeneration.
Ge J, Yang H, Chen Y, Yan Q, Wu C, Zou J
ACS biomaterials science & engineering 2019 Jul 8;5(7):3293-3302
ACS biomaterials science & engineering 2019 Jul 8;5(7):3293-3302
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Supportive validation
- Submitted by
- Boster Biological Technology (provider)
- Main image
- Experimental details
- Western blot analysis of Phospho-YAP1 (S127) expression in (1) HeLa cell lysate; (2) HeLa cell lysate treated with FBS+calyculin A.
- Additional image