66900-1-Ig

antibody from Proteintech Group

Targeting: YAP1 YAP65

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66900-1-Ig

Provider

Proteintech Group

Product name

YAP1 antibody

Antibody type

Monoclonal

Description

KD/KO validated YAP1 antibody (Cat. #66900-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3A7A9

Vial size

20ul, 150ul

References

Submitted references

Urolithin A exerts anti-tumor effects on gastric cancer via activating autophagy-Hippo axis and modulating the gut microbiota.

Qiao Y, Xia Q, Cao X, Xu J, Qiao Z, Wu L, Chen Z, Yang L, Lu X
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6633-6645

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EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.

Li Y, Zhu T, Yang J, Zhang Q, Xu S, Ge S, Jia R, Zhang J, Fan X
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203

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Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing.

Kong Q, Gao S, Li P, Sun H, Zhang Z, Yu X, Deng F, Wang T
International immunopharmacology 2024 Mar 30;130:111766

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EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma.

Bai J, Chen Y, Sun Y, Wang X, Wang Y, Guo S, Shang Z, Shao Z
Cellular and molecular life sciences : CMLS 2024 Jun 25;81(1):278

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Diosmetin ameliorates psoriasis-associated inflammation and keratinocyte hyperproliferation by modulation of PGC-1α / YAP signaling pathway.

Yang D, Peng M, Fu F, Zhao W, Zhang B
International immunopharmacology 2024 Jun 15;134:112248

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Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.

Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320

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CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression.

Gu Y, Wu S, Fan J, Meng Z, Gao G, Liu T, Wang Q, Xia H, Wang X, Wu K
Cell death & disease 2024 Jan 22;15(1):79

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A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

Chen L, Xu G, Song X, Zhang L, Chen C, Xiang G, Wang S, Zhang Z, Wu F, Yang X, Zhang L, Ma X, Yu J
Cancer letters 2024 Feb 28;583:216635

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The Prognostic Biomarker RAB7A Promotes Growth and Metastasis of Liver Cancer Cells by Regulating Glycolysis and YAP1 Activation.

Zhang JY, Zhu X, Liu Y, Wu X
Journal of cellular biochemistry 2024 Aug;125(8):e30621

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Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer.

Ying Y, Wu Y, Zhang F, Tang Y, Yi J, Ma X, Li J, Chen D, Wang X, Liu X, Liu B, Luo J, Zheng X, Xie L
Molecular cancer 2024 Apr 24;23(1):79

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Fibrotic Matrix Induces Mesenchymal Transformation of Epithelial Cells in Oral Submucous Fibrosis.

Xu HQ, Guo ZX, Yan JF, Wang SY, Gao JL, Han XX, Qin WP, Lu WC, Gao CH, Zhu WW, Fu YT, Jiao K
The American journal of pathology 2023 Sep;193(9):1208-1222

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Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation.

Liu J, Zhao C, Xiao X, Li A, Liu Y, Zhao J, Fan L, Liang Z, Pang W, Yao W, Li W, Zhou J
Nature communications 2023 Oct 13;14(1):6457

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ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.

Zhang Y, Wang Y, Li J, Li C, Liu W, Long X, Wang Z, Zhao R, Ge J, Shi B
Shock (Augusta, Ga.) 2023 Oct 1;60(4):573-584

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Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP-β-catenin-autophagy axis.

Li B, Du Y, He J, Lv X, Liu S, Zhang X, Zhang Y
Microbial pathogenesis 2023 Nov;184:106388

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Elastic modulus of hydrogel regulates osteogenic differentiation via liquid-liquid phase separation of YAP.

Tan K, Yang Q, Han Y, Zhuang Z, Zhao Y, Guo K, Tan A, Zheng Y, Li W
Journal of biomedical materials research. Part A 2023 Nov;111(11):1781-1797

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The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.

Tian Z, Xu C, He W, Lin Z, Zhang W, Tao K, Ding R, Zhang X, Dou K
Cancer letters 2023 Nov 28;577:216439

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Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

Guo Y, Cui Y, Li Y, Jin X, Wang D, Lei M, Chen F, Liu Y, Xu J, Yao G, Zeng G, Chen X
Cancer communications (London, England) 2023 May;43(5):582-612

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ATXN3 promotes prostate cancer progression by stabilizing YAP.

Wu L, Ou Z, Liu P, Zhao C, Tong S, Wang R, Li Y, Yuan J, Chen M, Fan B, Zu X, Wang Y, Tang J
Cell communication and signaling : CCS 2023 Jun 22;21(1):152

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Identification of ALG3 as a potential prognostic biomarker in lung adenocarcinoma.

Yuan Y, Xie B, Guo D, Liu C, Jiang G, Lai G, Zhang Y, Hu X, Wu Z, Zheng R, Huang L
Heliyon 2023 Jul;9(7):e18065

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VASN promotes colorectal cancer progression by activating the YAP/TAZ and AKT signaling pathways via YAP.

Liang W, Zuo J, Liu M, Su Y, Guo B, Hou J, Xing Q, Peng Y, Fang L, Cao Y, Shan J, Sun R, Zhao J, Wang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22688

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Alteration in branching morphogenesis via YAP/TAZ in fibroblasts of fetal lungs in an LPS-induced inflammation model.

Ko HS, Laiman V, Tsao PN, Chen CM, Chuang HC
Molecular medicine (Cambridge, Mass.) 2023 Jan 30;29(1):16

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The m(6)A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease.

Huang Z, Luo C, Hou X, Yu D, Su Y, Li X, Luo Y, Liao G, Mu J, Wu K
Pediatric surgery international 2023 Feb 15;39(1):126

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Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.

Chen S, Wu H, Wang Z, Jia M, Guo J, Jin J, Li X, Meng D, Lin L, He AR, Zhou P, Zhi X
Cellular and molecular gastroenterology and hepatology 2022;13(3):949-973.e7

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N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.

Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899

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Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.

Li TY, Su W, Li LL, Zhao XG, Yang N, Gai JX, Lv X, Zhang J, Huang MQ, Zhang Q, Ji WH, Song XY, Zhou YH, Li XL, Shan HL, Liang HH
Acta pharmacologica Sinica 2022 Nov;43(11):2862-2872

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Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1).

Khosravi F, Ahmadvand N, Wartenberg M, Sauer H
Biology 2022 Mar 30;11(4)

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Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

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Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.

Li Y, Yang J, Zhang Q, Xu S, Sun W, Ge S, Xu X, Jager MJ, Jia R, Zhang J, Fan X
Oncogene 2022 Jul;41(27):3539-3553

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Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema.

Chang JH, Lee YL, Laiman V, Han CL, Jheng YT, Lee KY, Yeh CT, Kuo HP, Chung KF, Heriyanto DS, Hsiao TC, Wu SM, Ho SC, Chuang KJ, Chuang HC
Chemico-biological interactions 2022 Jan 5;351:109763

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Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment.

Wang C, Zhu T, Zhao Z, Chen B, Chen T, Dong Q, Liu M, Zhuang S, Yang F, Liu Y, Yang M, Gu Y, Liang H
FEBS letters 2022 Feb;596(4):449-464

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The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.

Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781

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Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif.

Chen X, Wei X, Ma S, Xie H, Huang S, Yao M, Zhang L
Toxicology and applied pharmacology 2022 Dec 15;457:116319

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Reduction of Emphysema Severity by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Mice.

Laiman V, Lee YL, Hou YW, Fang YT, Chen YY, Lo YC, Heriyanto DS, Lan SC, Chen CL, Chen XY, Lee KY, Chang JH, Chuang HC
International journal of molecular sciences 2022 Aug 10;23(16)

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Fibrous Structure and Stiffness of Designer Protein Hydrogels Synergize to Regulate Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells.

Tian KK, Huang SC, Xia XX, Qian ZG
Biomacromolecules 2022 Apr 11;23(4):1777-1788

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Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells.

Hong L, Zha Y, Wang C, Qiao S, An J
Frontiers in molecular biosciences 2021;8:698698

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ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.

Li Y, Sun C, Tan Y, Zhang H, Li Y, Zou H
International journal of biological sciences 2021;17(2):635-650

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Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway.

Zuo W, Liu N, Zeng Y, Xiao Z, Wu K, Yang F, Li B, Song Q, Xiao Y, Liu Q
Frontiers in pharmacology 2021;12:663551

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FERM domain-containing protein 6 exerts a tumor-inhibiting role in thyroid cancer by antagonizing oncogenic YAP1.

Wang W, Zhao C, Quan F, Zhang P, Shao Y, Liu L
BioFactors (Oxford, England) 2021 Oct 20;

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YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β‑catenin expression in experimental bronchopulmonary dysplasia.

Jia X, Wu B, Huang J, Fan L, Yang M, Xu W
International journal of molecular medicine 2021 Jan;47(1):195-206

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Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.

Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796

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Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.

Zhang Q, Li W, Zhu Y, Wang Q, Zhai C, Shi W, Feng W, Wang J, Yan X, Chai L, Chen Y, Li C, Liu P, Li M
Molecular and cellular biochemistry 2021 Aug;476(8):3037-3049

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Yes-associated protein upregulates filopodia formation to promote alveolar epithelial-cell phagocytosis.

Gao P, Mu M, Chen Y, He J, Tao X, Song C
Immunology letters 2020 Sep;225:44-49

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Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression.

Cao MX, Zhang WL, Yu XH, Wu JS, Qiao XW, Huang MC, Wang K, Wu JB, Tang YJ, Jiang J, Liang XH, Tang YL
Journal of experimental & clinical cancer research : CR 2020 Jun 3;39(1):102

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CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.

Wang D, Luo Y, Wang G, Yang Q
Cell death & disease 2020 Jul 29;11(7):594

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VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro.

Bhandari A, Guan Y, Xia E, Huang Q, Chen Y
American journal of translational research 2019;11(6):3589-3599

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CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.

Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J
Cell death & disease 2019 Dec 11;10(12):949

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Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.

Zhang X, Fan Q, Li Y, Yang Z, Yang L, Zong Z, Wang B, Meng X, Li Q, Liu J, Li H
Oncotarget 2017 May 2;8(18):29785-29794