Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 16-9978-81 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IFN beta Monoclonal Antibody (A1 (IFNb)), Functional Grade, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The A1 monoclonal antibody reacts with human IFN-beta. The A1 antibody is a neutralizing antibody. IFN-beta is classified as a type I IFN which is a group of structurally and functionally related proteins demonstrating anti-viral, anti-parasitic, and anti-proliferative activities. Applications Reported: The A1 antibody has been reported for use in cytokine neutralization. Applications Tested: The Functional Grade Purified A1 antibody has been tested in bioassay for neutralization of IFN-beta bioactivity. The A1 antibody at 3-6 µg/mL has been found to inhibit by 50% the biological effects of 50 pg/mL human IFN-beta (ND50), in an EMCV assay of A549 cell protection. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the Best Protocols® section. Storage and handling: Use in a sterile environment. Filtration: 0.2 µm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- A1 (IFNb)
- Vial size
- 50 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C
Submitted references Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.
Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uzé G
Proceedings of the National Academy of Sciences of the United States of America 2005 Aug 16;102(33):11917-22
Proceedings of the National Academy of Sciences of the United States of America 2005 Aug 16;102(33):11917-22
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