Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Other assay [1]
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- Product number
- V3265 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- Desmoglein 1 Antibody / DSG1
- Antibody type
- Monoclonal
- Description
- Purified
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 27B2
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml
- Storage
- Store the DSG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Submitted references Characterization of desmoglein expression in the normal prostatic gland. Desmoglein 2 is an independent prognostic factor for aggressive prostate cancer.
Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma.
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection.
IgG-induced clustering of desmogleins 1 and 3 in skin of patients with pemphigus fits with the desmoglein nonassembly depletion hypothesis.
Desmosomal component expression in normal, dysplastic, and oral squamous cell carcinoma.
Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins.
Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1.
Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children.
Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering.
Human eccrine sweat gland cells can reconstitute a stratified epidermis.
Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder.
P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells.
Homo- and heterotypic cell contacts in malignant melanoma cells and desmoglein 2 as a novel solitary surface glycoprotein.
New skin-equivalent model from de-epithelialized amnion membrane.
Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle.
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.
Generation of monoclonal antibodies specific for desmoglein family members.
Barber AG, Castillo-Martin M, Bonal DM, Rybicki BA, Christiano AM, Cordon-Cardo C
PloS one 2014 Jun 4;9(6):e98786
PloS one 2014 Jun 4;9(6):e98786
Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma.
Xin Z, Yamaguchi A, Sakamoto K
Virchows Archiv : an international journal of pathology 2014 Jul;465(1):35-47
Virchows Archiv : an international journal of pathology 2014 Jul;465(1):35-47
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS
Science signaling 2013 Feb 5;6(261):ra8
Science signaling 2013 Feb 5;6(261):ra8
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection.
Wex T, Kuester D, Mönkemüller K, Stahr A, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P
Human pathology 2012 Oct;43(10):1745-54
Human pathology 2012 Oct;43(10):1745-54
IgG-induced clustering of desmogleins 1 and 3 in skin of patients with pemphigus fits with the desmoglein nonassembly depletion hypothesis.
Oktarina DA, van der Wier G, Diercks GF, Jonkman MF, Pas HH
The British journal of dermatology 2011 Sep;165(3):552-62
The British journal of dermatology 2011 Sep;165(3):552-62
Desmosomal component expression in normal, dysplastic, and oral squamous cell carcinoma.
Narayana N, Gist J, Smith T, Tylka D, Trogdon G, Wahl JK
Dermatology research and practice 2010;2010:649731
Dermatology research and practice 2010;2010:649731
Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins.
Brennan D, Hu Y, Medhat W, Dowling A, Mahoney MG
Dermatology research and practice 2010;2010:410278
Dermatology research and practice 2010;2010:410278
Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1.
Lin S, Gordon K, Kaplan N, Getsios S
Molecular biology of the cell 2010 Nov 15;21(22):3902-14
Molecular biology of the cell 2010 Nov 15;21(22):3902-14
Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children.
Cabral RM, Liu L, Hogan C, Dopping-Hepenstal PJ, Winik BC, Asial RA, Dobson R, Mein CA, Baselaga PA, Mellerio JE, Nanda A, Boente Mdel C, Kelsell DP, McGrath JA, South AP
The Journal of investigative dermatology 2010 Jun;130(6):1543-50
The Journal of investigative dermatology 2010 Jun;130(6):1543-50
Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering.
Simpson CL, Kojima S, Cooper-Whitehair V, Getsios S, Green KJ
The American journal of pathology 2010 Dec;177(6):2921-37
The American journal of pathology 2010 Dec;177(6):2921-37
Human eccrine sweat gland cells can reconstitute a stratified epidermis.
Biedermann T, Pontiggia L, Böttcher-Haberzeth S, Tharakan S, Braziulis E, Schiestl C, Meuli M, Reichmann E
The Journal of investigative dermatology 2010 Aug;130(8):1996-2009
The Journal of investigative dermatology 2010 Aug;130(8):1996-2009
Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder.
Winik BC, Asial RA, McGrath JA, South AP, Boente MC
The British journal of dermatology 2009 Apr;160(4):868-74
The British journal of dermatology 2009 Apr;160(4):868-74
P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells.
Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y
The Journal of dermatology 2008 Jun;35(6):317-24
The Journal of dermatology 2008 Jun;35(6):317-24
Homo- and heterotypic cell contacts in malignant melanoma cells and desmoglein 2 as a novel solitary surface glycoprotein.
Schmitt CJ, Franke WW, Goerdt S, Falkowska-Hansen B, Rickelt S, Peitsch WK
The Journal of investigative dermatology 2007 Sep;127(9):2191-206
The Journal of investigative dermatology 2007 Sep;127(9):2191-206
New skin-equivalent model from de-epithelialized amnion membrane.
Yang L, Shirakata Y, Shudou M, Dai X, Tokumaru S, Hirakawa S, Sayama K, Hamuro J, Hashimoto K
Cell and tissue research 2006 Oct;326(1):69-77
Cell and tissue research 2006 Oct;326(1):69-77
Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle.
Bazzi H, Getz A, Mahoney MG, Ishida-Yamamoto A, Langbein L, Wahl JK 3rd, Christiano AM
Differentiation; research in biological diversity 2006 Mar;74(2-3):129-40
Differentiation; research in biological diversity 2006 Mar;74(2-3):129-40
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK 3rd
Experimental dermatology 2006 Feb;15(2):101-9
Experimental dermatology 2006 Feb;15(2):101-9
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.
Wu H, Stanley JR, Cotsarelis G
The Journal of investigative dermatology 2003 Jun;120(6):1052-7
The Journal of investigative dermatology 2003 Jun;120(6):1052-7
Generation of monoclonal antibodies specific for desmoglein family members.
Wahl JK 3rd
Hybridoma and hybridomics 2002 Feb;21(1):37-44
Hybridoma and hybridomics 2002 Feb;21(1):37-44
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Supportive validation
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- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE Analysis of Purified, BSA-Free DSG1 Antibody (clone 27B2). Confirmation of Integrity and Purity of the Antibody.