RA0241

antibody from Oursmab

Targeting: F3 CD142, TF

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0241

Provider

Oursmab

Product name

Tisotumab (Biosimilar Reference Antibody) (F3)

Antibody type

Monoclonal

Description

Tisotumab vedotin is an antibody-drug conjugate (ADC) targeting tissue factor (TF, also known as CD142), a transmembrane protein overexpressed in many solid tumors. It consists of a human monoclonal antibody linked to the cytotoxic payload monomethyl auristatin E (MMAE). Upon binding to TF, the ADC is internalized, releasing MMAE to disrupt microtubule assembly and induce apoptosis. It is approved for the treatment of recurrent or metastatic cervical cancer, and is being studied in other TF-positive cancers.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Tisotumab (Biosimilar Reference Antibody) (F3)-RA0241-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Tisotumab (Biosimilar Reference Antibody) (F3)-RA0241 in a linear range of 15.63¨C125 ng/mL.