Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7960 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PPM1D polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PPM1D.
- Description
- Several major serine/threonine protein phosphatases have been identified in eukaryotic cells. These include protein phosphatase families 1, 2A, 2B, 2C, X and Y (PP-1, PP-2A, PP-2B, PP-2C, PP-X and PP-Y). These enzymes can be distinguished by their action on phosphorylase kinase and their sensitivity to certain activators and inhibitors. Wip1 (wildtype p53-induced phosphatase or PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP-2C family. Wip1 is a serine/threonine protein phosphatase which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53. Wip1 is ubiquitously expressed but is present at very high levels in testis. Deletion of Wip1 results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of PPM1D polyclonal antibody