ABIN392853

antibody from antibodies-online

Targeting: PPM1D PP2C-DELTA, Wip1

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN392853

Provider

antibodies-online

Product name

anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibody

Antibody type

Polyclonal

Antigen

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.

Reactivity

Human

Host

Rabbit

Vial size

0.1 mg

Concentration

0.25 mg/ml

Storage

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

References

Submitted references

p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors.

Park JY, Song JY, Kim HM, Han HS, Seol HS, Jang SJ, Choi J
The international journal of biochemistry & cell biology 2012 Jun;44(6):896-904

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Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.

Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X
Cancer research 2010 Sep 15;70(18):7176-86

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Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.

Song JY, Han HS, Sabapathy K, Lee BM, Yu E, Choi J
The Journal of biological chemistry 2010 Mar 19;285(12):9067-76

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The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.

Nguyen TA, Slattery SD, Moon SH, Darlington YF, Lu X, Donehower LA
DNA repair 2010 Jul 1;9(7):813-23

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Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA
The Journal of biological chemistry 2010 Apr 23;285(17):12935-47

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Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.

Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X
Cancer research 2009 Oct 15;69(20):7960-8