18413-1-AP

antibody from Proteintech Group

Targeting: FURIN FUR, PACE, PCSK3, SPC1

Provider product page for 18413-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]

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Product number: 18413-1-AP - Provider product page
Provider: Proteintech Group
Product name: FURIN antibody
Antibody type: Polyclonal
Description: KD/KO validated FURIN antibody (Cat. #18413-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FURIN protein structure - 18413-1-AP shown in red.

Submitted references The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

Makulyte G, Safwan-Zaiter H, Goehrig D, Huna A, Mangelinck A, Mikawa T, Palazzo A, Moudombi L, Medard JJ, Chanal M, Lecot P, Michallet MC, Gavard J, Adnot S, Dubus P, Kondoh H, Mann C, Tan NS, Bertolino P, Flaman JM, Bernard D
Aging cell 2026 Jan;25(1):e70307

Integration of Single-Cell RNA Sequencing and Machine Learning to Identify and Validate Prognostic Genes With Lymph Node Metastasis and Immune Cell Signatures in Lung Adenocarcinoma.

Lin C, Chen X, Sun Y, Tang X, Jiang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71783

Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent entry of porcine deltacoronavirus into Huh7 cells.

Xiao W, Xiong Y, Wang Y, Li T, Chen C, Shi Y, Su G, Zhou Y, Xiao S, Fang L
Journal of virology 2025 Sep 23;99(9):e0105525

CENPU promotes tumorigenesis and stem cell properties in triple‑negative breast cancer by suppressing lysosomal furin degradation.

Sun S, Hou Z, Qiang L, Zhou D
International journal of molecular medicine 2025 Dec;56(6)

Urotensin II system contributes to ischemic acute kidney injury in neonatal pigs.

de la Cruz JE, Michael OS, Kanthakumar P, Falayi OO, Iwhiwhu SA, Afolabi JM, Kumar R, Soni H, Adebiyi A
Renal failure 2025 Dec;47(1):2534018

Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin.

Grinstein-Koren O, Lusthaus M, Tabibian-Keissar H, Kaplan I, Buchner A, Ilatov R, Vered M, Zlotogorski-Hurvitz A
PloS one 2024;19(3):e0300269

Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination.

Su W, Ahmad I, Wu Y, Tang L, Khan I, Ye B, Liang J, Li S, Zheng YH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2403732

Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection.

Zhang T, Li Y, Pan L, Sha J, Bailey M, Faure-Kumar E, Williams CK, Wohlschlegel J, Magaki S, Niu C, Lee Y, Su YC, Li X, Vinters HV, Geschwind DH
Nature aging 2024 Nov;4(11):1598-1618

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.

Yuan Y, Xu J, Jiang Q, Yang C, Wang N, Liu X, Piao HL, Lu S, Zhang X, Han L, Liu Z, Cai J, Liu F, Chen S, Liu J
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133

Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury.

Mao Y, Chen Y, Li Y, Ma L, Wang X, Wang Q, He A, Liu X, Dong T, Gao W, Xu Y, Liu L, Ren L, Liu Q, Zhou P, Hu B, Zhou Y, Tian R, Shi ZL
Cell reports 2024 Feb 27;43(2):113689

Expression of SARS-CoV-2 entry molecules ACE2, NRP1, TMPRSS2, and FURIN in the reproductive tissues of male macaques.

Moriyama R, Nakamura S, Mitsui I, Sugiyama M, Fukui H, Fukui H, Hagiwara T, Miyabe-Nishiwaki T, Suzuki J
Histochemistry and cell biology 2024 Dec;162(6):465-475

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus.

Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Yang J, Pekosz A, Zhang Y, Wang J
bioRxiv : the preprint server for biology 2024 Dec 5;

Social defeat stress impairs systemic iron metabolism by activating the hepcidin-ferroportin axis.

Kasahara E, Nakamura A, Morimoto K, Ito S, Hori M, Sekiyama A
FASEB bioAdvances 2024 Aug;6(8):263-275

Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2.

Yu S, Zheng X, Zhou Y, Gao Y, Zhou B, Zhao Y, Li T, Li Y, Mou J, Cui X, Yang Y, Li D, Chen M, Lavillette D, Meng G
PLoS pathogens 2023 Nov;19(11):e1011789

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry.

Smith TJ, Fusco RM, Elmore ZC, Asokan A
Journal of virology 2023 May 31;97(5):e0009323

Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps.

Wang T, Zhou Y, Zhou Z, Zhang P, Yan R, Sun L, Ma W, Zhang T, Shen S, Liu H, Lu H, Ye L, Feng J, Chen Z, Zhong X, Wu G, Cai Y, Jia W, Gao P, Zhang H
Nature communications 2023 Mar 18;14(1):1513

Tibetan medicine Liuwei Muxiang pills (LWMX pills) effectively protects mice from chronic non-atrophic gastritis.

Dhondrup R, Tidwell T, Zhang X, Feng X, Lobsang D, Hua Q, Geri D, Suonan DC, Fan G, Samdrup G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154826

Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796.

Long A, Liu Y, Fang X, Jia L, Li Z, Hu J, Wu S, Chen C, Huang P, Wang Y
Cell research 2023 Apr;33(4):273-287

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders.

Allen CNS, Arjona SP, Santerre M, De Lucia C, Koch WJ, Sawaya BE
Frontiers in cellular neuroscience 2022;16:812887

Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages.

Arnan C, Ullrich S, Pulido-Quetglas C, Nurtdinov R, Esteban A, Blanco-Fernandez J, Aparicio-Prat E, Johnson R, Pérez-Lluch S, Guigó R
BMC genomics 2022 May 26;23(1):402

Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts.

Wang W, Wei Q, Hao Q, Zhang Y, Li Y, Bi Y, Jin Z, Liu H, Liu X, Yang Z, Xiao S
Frontiers in microbiology 2021;12:607451

Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.

Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
Physiological reports 2021 Sep;9(17):e15014

Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.

Farhat D, Léon S, Ghayad SE, Gadot N, Icard P, Le Romancer M, Hussein N, Lincet H
British journal of cancer 2020 Mar;122(6):885-894

Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells.

Wang H, Li J, He J, Liu Y, Feng W, Zhou H, Zhou M, Wei H, Lu Y, Peng W, Du F, Gong A, Xu M
Oncogenesis 2020 Aug 26;9(8):76

Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.

Farhat D, Ghayad SE, Icard P, Le Romancer M, Hussein N, Lincet H
Oncogene 2020 Apr;39(17):3604-3610

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

Yu X, Dobrikov M, Keir ST, Gromeier M, Pastan IH, Reisfeld R, Bigner DD, Chandramohan V
PloS one 2019;14(1):e0210608

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Buck JM, O'Neill HC, Stitzel JA
Biochemical pharmacology 2019 Oct;168:438-451

Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.

Zhou M, Zhang Y, Wei H, He J, Wang D, Chen B, Zeng J, Gong A, Xu M
Oncology letters 2018 Mar;15(3):3192-3196

SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.

Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652

Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.

Zhang Y, Zhou M, Wei H, Zhou H, He J, Lu Y, Wang D, Chen B, Zeng J, Peng W, Du F, Gong A, Xu M
International journal of oncology 2017 Apr;50(4):1352-1362

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 18413-1-AP( FURIN Antibody) at dilution of 1:600
Validation comment: WB
Appendix: 18413-1-AP.pdf

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