18413-1-AP

antibody from Proteintech Group

Targeting: FURIN FUR, PACE, PCSK3, SPC1

Provider product page for 18413-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]

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Product number: 18413-1-AP - Provider product page
Provider: Proteintech Group
Product name: FURIN antibody
Antibody type: Polyclonal
Description: KD/KO validated FURIN antibody (Cat. #18413-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FURIN protein structure - 18413-1-AP shown in red.

Submitted references Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin.

Grinstein-Koren O, Lusthaus M, Tabibian-Keissar H, Kaplan I, Buchner A, Ilatov R, Vered M, Zlotogorski-Hurvitz A
PloS one 2024;19(3):e0300269

Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury.

Mao Y, Chen Y, Li Y, Ma L, Wang X, Wang Q, He A, Liu X, Dong T, Gao W, Xu Y, Liu L, Ren L, Liu Q, Zhou P, Hu B, Zhou Y, Tian R, Shi ZL
Cell reports 2024 Feb 27;43(2):113689

Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2.

Yu S, Zheng X, Zhou Y, Gao Y, Zhou B, Zhao Y, Li T, Li Y, Mou J, Cui X, Yang Y, Li D, Chen M, Lavillette D, Meng G
PLoS pathogens 2023 Nov;19(11):e1011789

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry.

Smith TJ, Fusco RM, Elmore ZC, Asokan A
Journal of virology 2023 May 31;97(5):e0009323

Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps.

Wang T, Zhou Y, Zhou Z, Zhang P, Yan R, Sun L, Ma W, Zhang T, Shen S, Liu H, Lu H, Ye L, Feng J, Chen Z, Zhong X, Wu G, Cai Y, Jia W, Gao P, Zhang H
Nature communications 2023 Mar 18;14(1):1513

Tibetan medicine Liuwei Muxiang pills (LWMX pills) effectively protects mice from chronic non-atrophic gastritis.

Dhondrup R, Tidwell T, Zhang X, Feng X, Lobsang D, Hua Q, Geri D, Suonan DC, Fan G, Samdrup G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154826

Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796.

Long A, Liu Y, Fang X, Jia L, Li Z, Hu J, Wu S, Chen C, Huang P, Wang Y
Cell research 2023 Apr;33(4):273-287

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders.

Allen CNS, Arjona SP, Santerre M, De Lucia C, Koch WJ, Sawaya BE
Frontiers in cellular neuroscience 2022;16:812887

Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages.

Arnan C, Ullrich S, Pulido-Quetglas C, Nurtdinov R, Esteban A, Blanco-Fernandez J, Aparicio-Prat E, Johnson R, Pérez-Lluch S, Guigó R
BMC genomics 2022 May 26;23(1):402

Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts.

Wang W, Wei Q, Hao Q, Zhang Y, Li Y, Bi Y, Jin Z, Liu H, Liu X, Yang Z, Xiao S
Frontiers in microbiology 2021;12:607451

Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.

Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
Physiological reports 2021 Sep;9(17):e15014

Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.

Farhat D, Léon S, Ghayad SE, Gadot N, Icard P, Le Romancer M, Hussein N, Lincet H
British journal of cancer 2020 Mar;122(6):885-894

Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells.

Wang H, Li J, He J, Liu Y, Feng W, Zhou H, Zhou M, Wei H, Lu Y, Peng W, Du F, Gong A, Xu M
Oncogenesis 2020 Aug 26;9(8):76

Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.

Farhat D, Ghayad SE, Icard P, Le Romancer M, Hussein N, Lincet H
Oncogene 2020 Apr;39(17):3604-3610

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

Yu X, Dobrikov M, Keir ST, Gromeier M, Pastan IH, Reisfeld R, Bigner DD, Chandramohan V
PloS one 2019;14(1):e0210608

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Buck JM, O'Neill HC, Stitzel JA
Biochemical pharmacology 2019 Oct;168:438-451

Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.

Zhou M, Zhang Y, Wei H, He J, Wang D, Chen B, Zeng J, Gong A, Xu M
Oncology letters 2018 Mar;15(3):3192-3196

SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.

Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652

Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.

Zhang Y, Zhou M, Wei H, Zhou H, He J, Lu Y, Wang D, Chen B, Zeng J, Peng W, Du F, Gong A, Xu M
International journal of oncology 2017 Apr;50(4):1352-1362

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 18413-1-AP( FURIN Antibody) at dilution of 1:600
Validation comment: WB
Appendix: 18413-1-AP.pdf

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