Antibody data
- Antibody Data
- Antigen structure
- References [41]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 13700-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13700-1-AP, RRID:AB_10666436
- Product name
- TBX21,T-bet antibody
- Antibody type
- Polyclonal
- Description
- TBX21,T-bet antibody (Cat. #13700-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity.
BTK-Inhibitor Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Targeting Elimination of Autoreactive BAFFR(high) B Cells.
TBX21 knockdown attenuates neuroinflammation induced by intracerebral hemorrhage via the SIRT1-WDR5-H3K4me3 axis.
Study on the regulation of Treg cell infiltration by EZH2 through CXCR4/CXCL12 in diffuse large B-cell lymphoma.
Expansion of peripheral cytotoxic CD4+ T cells in Alzheimer's disease: New insights from multi-omics evidence.
The protective effects and mechanisms of essential oil from Chimonanthus nitens Oliv. leaves in allergic rhinitis based on the NF-κB and T-bet/GATA-3 signaling pathways.
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis.
Effect of 3D-Printed Polycaprolactone Scaffold With Powdery/Smooth Micromorphology on Local Immune Environments.
Prognostic value of LPAR1 expression and methylation in low-grade gliomas: a meta-analysis of TCGA and CGGA datasets and functional validation.
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
Combination of androgen and estrogen improves asthma by mediating Runx3 expression.
Abnormal miR-122-5p expression in decidual NK cells and its impact on trophoblast behavior: insights into unexplained recurrent pregnancy loss.
A mannose-rich exopolysaccharide-1 isolated from Bifidobacterium breve mitigates ovalbumin-induced intestinal damage in mice by modulation CD4 + T cell differentiation and inhibiting NF-κB signaling pathway.
Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway.
Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats.
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota.
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.
The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8(+) T cell fates.
Environmental Low-Dose Radiation Activates Th1 Immunity through the Mitochondria-STING Pathway.
Androgens have therapeutic potential in T2 asthma by mediating METTL3 in bronchial epithelial cells.
Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.
Long-term consequences of regulatory T-cell-specific knockout of Notch2 in immune homeostasis.
PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.
Cisplatin Promotes the Efficacy of Immune Checkpoint Inhibitor Therapy by Inducing Ferroptosis and Activating Neutrophils.
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2 Balance in DNCB-Induced BALB/c Mice.
Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion.
Maggot extracts promote regulatory T cell differentiation by upregulating Foxp3 in allergic rhinitis.
Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.
IL-27 Mediates Th1 Cells Infiltration in Fetal Membranes in Preterm Labor.
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.
Effect of IL-17 in the development of colon cancer in mice.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome.
Inhibition of Pim-1 kinase ameliorates dextran sodium sulfate-induced colitis in mice.
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Zhang Y, Wen J, Jiang B, Jiang H, Xu J, Tao J
International journal of molecular sciences 2026 Jan 11;27(2)
International journal of molecular sciences 2026 Jan 11;27(2)
TBX21 knockdown attenuates neuroinflammation induced by intracerebral hemorrhage via the SIRT1-WDR5-H3K4me3 axis.
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Study on the regulation of Treg cell infiltration by EZH2 through CXCR4/CXCL12 in diffuse large B-cell lymphoma.
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Expansion of peripheral cytotoxic CD4+ T cells in Alzheimer's disease: New insights from multi-omics evidence.
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The protective effects and mechanisms of essential oil from Chimonanthus nitens Oliv. leaves in allergic rhinitis based on the NF-κB and T-bet/GATA-3 signaling pathways.
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Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118908
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Effect of 3D-Printed Polycaprolactone Scaffold With Powdery/Smooth Micromorphology on Local Immune Environments.
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BMC cancer 2025 Dec 30;26(1):161
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
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Combination of androgen and estrogen improves asthma by mediating Runx3 expression.
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International journal of medical sciences 2024;21(6):1003-1015
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Abnormal miR-122-5p expression in decidual NK cells and its impact on trophoblast behavior: insights into unexplained recurrent pregnancy loss.
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International journal of medical sciences 2024;21(14):2824-2836
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A mannose-rich exopolysaccharide-1 isolated from Bifidobacterium breve mitigates ovalbumin-induced intestinal damage in mice by modulation CD4 + T cell differentiation and inhibiting NF-κB signaling pathway.
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Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota.
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HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
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HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.
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Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
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Molecular nutrition & food research 2024 Feb;68(3):e2300602
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Nature immunology 2024 Feb;25(2):294-306
Environmental Low-Dose Radiation Activates Th1 Immunity through the Mitochondria-STING Pathway.
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Androgens have therapeutic potential in T2 asthma by mediating METTL3 in bronchial epithelial cells.
Chen Z, Shang Y, Duan W, Zhu L, Ji X, Gong S, Xiang X
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International immunopharmacology 2024 Dec 25;143(Pt 1):113322
Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.
Pu S, Yang Z, Zhang X, Li M, Han N, Yang X, He J, Yu G, Meng X, Jia Q, Shao H
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Chinese medicine 2023 Oct 12;18(1):131
Long-term consequences of regulatory T-cell-specific knockout of Notch2 in immune homeostasis.
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International immunopharmacology 2023 Nov;124(Pt B):111069
International immunopharmacology 2023 Nov;124(Pt B):111069
PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.
Yu M, Tang W, Liang W, Xie B, Gao R, Ding P, Gu X, Wang M, Wen S, Sun P
International immunopharmacology 2023 Nov;124(Pt B):110962
International immunopharmacology 2023 Nov;124(Pt B):110962
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2300738
Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.
Li Z, Ma D, Wang Y, Wu S, Wang L, Jiang Y, Zhang Y, Li X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7421265
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7421265
Cisplatin Promotes the Efficacy of Immune Checkpoint Inhibitor Therapy by Inducing Ferroptosis and Activating Neutrophils.
Zhou Z, Zhao Y, Chen S, Cui G, Fu W, Li S, Lin X, Hu H
Frontiers in pharmacology 2022;13:870178
Frontiers in pharmacology 2022;13:870178
Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.
Feng JY, Xie YQ, Zhang P, Zhou Q, Khan A, Zhou ZH, Xia XS, Liu L
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)
Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2 Balance in DNCB-Induced BALB/c Mice.
Zeng ZW, Huang JQ, Chen Y, Yu X, Zhu W, Zhang DS
Chinese journal of integrative medicine 2022 Jul;28(7):612-619
Chinese journal of integrative medicine 2022 Jul;28(7):612-619
Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion.
Bi SJ, Huang YX, Feng LM, Yue SJ, Chen YY, Fu RJ, Xu DQ, Tang YP
Journal of ethnopharmacology 2022 Jan 10;282:114609
Journal of ethnopharmacology 2022 Jan 10;282:114609
Maggot extracts promote regulatory T cell differentiation by upregulating Foxp3 in allergic rhinitis.
Liu L, Deng YQ, Jiao WE, Qiao YL, Tao ZZ, Wang Y, Hua QQ, Chen SM
American journal of translational research 2021;13(12):13540-13554
American journal of translational research 2021;13(12):13540-13554
Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.
Li W, Zhou Y, Wu Z, Shi Y, Tian E, Zhu Y, Wang T, Dou W, Meng X, Chen M, Zhai B, Zhu D
Frontiers in pharmacology 2021;12:724306
Frontiers in pharmacology 2021;12:724306
IL-27 Mediates Th1 Cells Infiltration in Fetal Membranes in Preterm Labor.
Mei Y, Ran Y, Liu Z, Zhou Y, He J, Yin N, Qi H
Reproductive sciences (Thousand Oaks, Calif.) 2021 Dec 2;
Reproductive sciences (Thousand Oaks, Calif.) 2021 Dec 2;
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.
Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, Elarabi H, Croft CA, Doisne JM, Zhang P, Weisshaar M, Jarrossay D, Latorre D, Shen Y, Han J, Ogishi M, Gruber C, Markle J, Al Ali F, Rahman M, Khan T, Seeleuthner Y, Kerner G, Husquin LT, Maclsaac JL, Jeljeli M, Errami A, Ailal F, Kobor MS, Oleaga-Quintas C, Roynard M, Bourgey M, El Baghdadi J, Boisson-Dupuis S, Puel A, Batteux F, Rozenberg F, Marr N, Pan-Hammarström Q, Bogunovic D, Quintana-Murci L, Carroll T, Ma CS, Abel L, Bousfiha A, Di Santo JP, Glimcher LH, Gros P, Tangye SG, Sallusto F, Bustamante J, Casanova JL
Cell 2020 Dec 23;183(7):1826-1847.e31
Cell 2020 Dec 23;183(7):1826-1847.e31
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Xia Y, Yu B, Ma C, Tu Y, Zhai L, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.
Johnson RM, Yu H, Strank NO, Karunakaran K, Zhu Y, Brunham RC
Infection and immunity 2018 Feb;86(2)
Infection and immunity 2018 Feb;86(2)
Effect of IL-17 in the development of colon cancer in mice.
Yang L, Liu H, Zhang L, Hu J, Chen H, Wang L, Yin X, Li Q, Qi Y
Oncology letters 2016 Dec;12(6):4929-4936
Oncology letters 2016 Dec;12(6):4929-4936
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Chen H, Fu T, Suh WK, Tsavachidou D, Wen S, Gao J, Ng Tang D, He Q, Sun J, Sharma P
Cancer immunology research 2014 Feb;2(2):167-76
Cancer immunology research 2014 Feb;2(2):167-76
Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome.
Lu Y, Li L, Yan H, Su Q, Huang J, Fu C
International journal of cardiology 2013 Oct 15;168(6):5396-404
International journal of cardiology 2013 Oct 15;168(6):5396-404
Inhibition of Pim-1 kinase ameliorates dextran sodium sulfate-induced colitis in mice.
Shen YM, Zhao Y, Zeng Y, Yan L, Chen BL, Leng AM, Mu YB, Zhang GY
Digestive diseases and sciences 2012 Jul;57(7):1822-31
Digestive diseases and sciences 2012 Jul;57(7):1822-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The TBX21,T-bet antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TBX21,T-bet. This antibody recognizes human, mouse antigen. The TBX21,T-bet antibody has been validated for the following applications: ELISA, WB analysis.