13700-1-AP

antibody from Proteintech Group

Targeting: TBX21 T-bet, TBLYM

Provider product page for 13700-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]

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Product number: 13700-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13700-1-AP, RRID:AB_10666436
Product name: TBX21,T-bet antibody
Antibody type: Polyclonal
Description: TBX21,T-bet antibody (Cat. #13700-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TBX21 protein structure - 13700-1-AP shown in red.

Submitted references Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway.

Kun W, Xiaomei C, Lei Y, Huizhi Z
International immunopharmacology 2024 Mar 30;130:111713

Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats.

Luo J, Liang C, Chen K, Zeng K, Bai R, Tang C, Li J, Nong X
BMC oral health 2024 Mar 20;24(1):356

Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota.

Hu Y, Tang J, Xie Y, Xu W, Zhu W, Xia L, Fang J, Yu D, Liu J, Zheng Z, Zhou Q, Shou Q, Zhang W
Journal of ethnopharmacology 2024 Jun 28;328:117956

HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy.

Wen Y, Ye S, Li Z, Zhang X, Liu C, Wu Y, Zheng R, Xu C, Tian J, Shu L, Yan Q, Ai F, Ma J
Cancer immunology, immunotherapy : CII 2024 Jan 17;73(1):7

A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.

Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
Molecular nutrition & food research 2024 Feb;68(3):e2300602

Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.

Pu S, Yang Z, Zhang X, Li M, Han N, Yang X, He J, Yu G, Meng X, Jia Q, Shao H
Chinese medicine 2023 Oct 12;18(1):131

Long-term consequences of regulatory T-cell-specific knockout of Notch2 in immune homeostasis.

Fan HM, Qiao YL, Liu Y, Xu S, Ni HF, Jiao WE, Tao ZZ, Chen SM
International immunopharmacology 2023 Nov;124(Pt B):111069

PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.

Yu M, Tang W, Liang W, Xie B, Gao R, Ding P, Gu X, Wang M, Wen S, Sun P
International immunopharmacology 2023 Nov;124(Pt B):110962

Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.

Zhao Y, Zhang J, Cheng X, Huang W, Shen S, Wu S, Huang Y, Nie G, Wang H, Qiu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2300738

Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.

Li Z, Ma D, Wang Y, Wu S, Wang L, Jiang Y, Zhang Y, Li X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7421265

Cisplatin Promotes the Efficacy of Immune Checkpoint Inhibitor Therapy by Inducing Ferroptosis and Activating Neutrophils.

Zhou Z, Zhao Y, Chen S, Cui G, Fu W, Li S, Lin X, Hu H
Frontiers in pharmacology 2022;13:870178

Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism.

Feng JY, Xie YQ, Zhang P, Zhou Q, Khan A, Zhou ZH, Xia XS, Liu L
Molecules (Basel, Switzerland) 2022 Jun 3;27(11)

Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2 Balance in DNCB-Induced BALB/c Mice.

Zeng ZW, Huang JQ, Chen Y, Yu X, Zhu W, Zhang DS
Chinese journal of integrative medicine 2022 Jul;28(7):612-619

Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion.

Bi SJ, Huang YX, Feng LM, Yue SJ, Chen YY, Fu RJ, Xu DQ, Tang YP
Journal of ethnopharmacology 2022 Jan 10;282:114609

Maggot extracts promote regulatory T cell differentiation by upregulating Foxp3 in allergic rhinitis.

Liu L, Deng YQ, Jiao WE, Qiao YL, Tao ZZ, Wang Y, Hua QQ, Chen SM
American journal of translational research 2021;13(12):13540-13554

Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.

Li W, Zhou Y, Wu Z, Shi Y, Tian E, Zhu Y, Wang T, Dou W, Meng X, Chen M, Zhai B, Zhu D
Frontiers in pharmacology 2021;12:724306

IL-27 Mediates Th1 Cells Infiltration in Fetal Membranes in Preterm Labor.

Mei Y, Ran Y, Liu Z, Zhou Y, He J, Yin N, Qi H
Reproductive sciences (Thousand Oaks, Calif.) 2021 Dec 2;

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.

Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, Elarabi H, Croft CA, Doisne JM, Zhang P, Weisshaar M, Jarrossay D, Latorre D, Shen Y, Han J, Ogishi M, Gruber C, Markle J, Al Ali F, Rahman M, Khan T, Seeleuthner Y, Kerner G, Husquin LT, Maclsaac JL, Jeljeli M, Errami A, Ailal F, Kobor MS, Oleaga-Quintas C, Roynard M, Bourgey M, El Baghdadi J, Boisson-Dupuis S, Puel A, Batteux F, Rozenberg F, Marr N, Pan-Hammarström Q, Bogunovic D, Quintana-Murci L, Carroll T, Ma CS, Abel L, Bousfiha A, Di Santo JP, Glimcher LH, Gros P, Tangye SG, Sallusto F, Bustamante J, Casanova JL
Cell 2020 Dec 23;183(7):1826-1847.e31

Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.

Xia Y, Yu B, Ma C, Tu Y, Zhai L, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338

B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.

Johnson RM, Yu H, Strank NO, Karunakaran K, Zhu Y, Brunham RC
Infection and immunity 2018 Feb;86(2)

Effect of IL-17 in the development of colon cancer in mice.

Yang L, Liu H, Zhang L, Hu J, Chen H, Wang L, Yin X, Li Q, Qi Y
Oncology letters 2016 Dec;12(6):4929-4936

CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.

Chen H, Fu T, Suh WK, Tsavachidou D, Wen S, Gao J, Ng Tang D, He Q, Sun J, Sharma P
Cancer immunology research 2014 Feb;2(2):167-76

Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome.

Lu Y, Li L, Yan H, Su Q, Huang J, Fu C
International journal of cardiology 2013 Oct 15;168(6):5396-404

Inhibition of Pim-1 kinase ameliorates dextran sodium sulfate-induced colitis in mice.

Shen YM, Zhao Y, Zeng Y, Yan L, Chen BL, Leng AM, Mu YB, Zhang GY
Digestive diseases and sciences 2012 Jul;57(7):1822-31

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TBX21,T-bet antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TBX21,T-bet. This antibody recognizes human, mouse antigen. The TBX21,T-bet antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13700-1-AP.pdf

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