GUCY1A2

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Description

Guanylate cyclase 1 soluble subunit alpha 2

Tissue specificity

Tissue enhanced (placenta)

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (106674019 - 107018476)

Ensembl ID

ENSG00000152402  (ver. 103.38)

Orthologs

Mouse Gucy1a2: ENSMUSG00000041624

UniProt

P33402

neXtProt

NX_P33402

Human splice variants
Mouse splice variants

Protein structure