BS3070

antibody from Bioworld Technology, Inc
Targeting: SCNN1D dNaCh, ENaCdelta
Provider product page for BS3070
Western blot
Immunocytochemistry

Antibody data

Product number
BS3070 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS3070, RRID:AB_1662629
Product name
ENaCÑ´ (P446) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 430-480 of Human ENaCÑ´.
Description
The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, Ï«, ÉÇ, ÎÛ and Ñ´. The most frequently formed heterotetramer consists of 2Ï«, 1ÉÇ, and 1ÎÛ subunit, but the Ï« subunit can be replaced by a Ñ´ subunit. The Ï«ENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the ÉÇ and ÎÛENaC genes map to human chromosome 16p12, and the ÎÛENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle£ªs syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SCNN1D protein structure - BS3070 shown in red.