Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 20258-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20258-1-AP, RRID:AB_2800493
- Product name
- SYN1-Specific antibody
- Antibody type
- Polyclonal
- Description
- SYN1-Specific antibody (Cat. #20258-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity.
Increased intestinal bile acid absorption contributes to age-related cognitive impairment.
Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10.
Icariin rescues developmental BPA exposure induced spatial memory deficits in rats.
Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder.
Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome.
SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy.
GDF1 ameliorates cognitive impairment induced by hearing loss.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells.
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice.
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway.
Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation.
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
Identification of residues critical for the extension of Munc18-1 domain 3a.
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.
Cofilin promotes tau pathology in Alzheimer's disease.
Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
Ursolic Acid Ameliorates Spinal Cord Injury in Mice by Regulating Gut Microbiota and Metabolic Changes.
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice.
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.
sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway.
Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury.
Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties.
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Electroacupuncture improves neuronal plasticity through the A2AR/cAMP/PKA signaling pathway in SNL rats.
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Hippocampal alpha-synuclein mediates depressive-like behaviors.
Proteomics Analysis of Brain Tissue in a Rat Model of Ischemic Stroke in the Acute Phase.
Control the fate of human umbilical cord mesenchymal stem cells with dual-enzymatically cross-linked gelatin hydrogels for potential applications in nerve regeneration.
Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease.
Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
iTRAQ-Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke.
High glucose-induced defective thrombospondin-1 release from astrocytes via TLR9 activation contributes to the synaptic protein loss.
Zhao M, Ren Z, Zhao A, Tang Y, Kuang J, Li M, Chen T, Wang S, Wang J, Zhang H, Wang J, Zhang T, Zeng J, Liu X, Xie G, Liu P, Sun N, Bao T, Nie T, Lin J, Liu P, Zheng Y, Zheng X, Liu T, Jia W
Cell metabolism 2024 May 7;36(5):1000-1012.e6
Cell metabolism 2024 May 7;36(5):1000-1012.e6
Increased intestinal bile acid absorption contributes to age-related cognitive impairment.
Ren Z, Zhao L, Zhao M, Bao T, Chen T, Zhao A, Zheng X, Gu X, Sun T, Guo Y, Tang Y, Xie G, Jia W
Cell reports. Medicine 2024 May 21;5(5):101543
Cell reports. Medicine 2024 May 21;5(5):101543
Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10.
Ma Z, Liu K, Zhang RF, Xie ZX, Liu W, Xu B
The Science of the total environment 2024 Mar 10;915:170021
The Science of the total environment 2024 Mar 10;915:170021
Icariin rescues developmental BPA exposure induced spatial memory deficits in rats.
Li D, Ai S, Huang C, Liu ZH, Wang HL
Toxicology and applied pharmacology 2024 Jan;482:116776
Toxicology and applied pharmacology 2024 Jan;482:116776
Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder.
Valeri J, Stiplosek C, O'Donovan SM, Sinclair D, Grant K, Bollavarapu R, Platt DM, Stockmeier CA, Gisabella B, Pantazopoulos H
medRxiv : the preprint server for health sciences 2024 Jan 2;
medRxiv : the preprint server for health sciences 2024 Jan 2;
Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome.
Han S, Bian R, Chen Y, Liang J, Zhao P, Gu Y, Zhang D
Molecular neurobiology 2024 Dec;61(12):10500-10516
Molecular neurobiology 2024 Dec;61(12):10500-10516
SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy.
Wang J, Dai L, Deng M, Xiao T, Zhang Z, Zhang Z
Molecular neurobiology 2024 Apr;61(4):2446-2458
Molecular neurobiology 2024 Apr;61(4):2446-2458
GDF1 ameliorates cognitive impairment induced by hearing loss.
Pan L, Li C, Meng L, Zhang G, Zou L, Tian Y, Chen S, Sun Y, Su D, Zhang X, Xiong M, Xiao T, Xia D, Hong Z, Zhang Z
Nature aging 2024 Apr;4(4):568-583
Nature aging 2024 Apr;4(4):568-583
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974
Nature communications 2024 Apr 6;15(1):2974
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Hu Y, Hu C, Yin J, Zhong J, Deng Y, Yang G
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells.
Liu Z, Xu K, Pan S, Zhang N, Wang D, Chen Y, Zhao Y, Wang S, Li J, Tong X
Brain research bulletin 2023 Nov;204:110795
Brain research bulletin 2023 Nov;204:110795
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
Meng L, Liu C, Li Y, Chen G, Xiong M, Yu T, Pan L, Zhang X, Zhou L, Guo T, Yuan X, Liu C, Zhang Z, Zhang Z
Science advances 2023 Nov 3;9(44):eadj1092
Science advances 2023 Nov 3;9(44):eadj1092
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Meng L, Liu C, Liu M, Chen J, Liu C, Zhang Z, Chen G, Zhang Z
Cell reports 2023 Nov 28;42(11):113342
Cell reports 2023 Nov 28;42(11):113342
Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice.
Wang Z, Niu M, Zheng N, Meng J, Jiang Y, Yang D, Yao P, Yao T, Luo H, Xu H, Ge Y, Zhang YW, Zhang X
Journal of cellular and molecular medicine 2023 May;27(9):1214-1226
Journal of cellular and molecular medicine 2023 May;27(9):1214-1226
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway.
Zong Q, Pan Y, Liu Y, Wu Z, Huang Z, Zhang Y, Ma K
International immunopharmacology 2023 Mar;116:109727
International immunopharmacology 2023 Mar;116:109727
Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation.
Liang J, Han S, Ye C, Zhu H, Wu J, Nie Y, Chai G, Zhao P, Zhang D
Brain sciences 2023 Mar 19;13(3)
Brain sciences 2023 Mar 19;13(3)
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
Meng L, Li Y, Liu C, Zhang G, Chen J, Xiong M, Pan L, Zhang X, Chen G, Xiong J, Liu C, Xu X, Bu L, Zhang Z, Zhang Z
Progress in neurobiology 2023 Jul;226:102462
Progress in neurobiology 2023 Jul;226:102462
Identification of residues critical for the extension of Munc18-1 domain 3a.
Wang X, Gong J, Zhu L, Chen H, Jin Z, Mo X, Wang S, Yang X, Ma C
BMC biology 2023 Jul 13;21(1):158
BMC biology 2023 Jul 13;21(1):158
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.
Li B, Lu Y, Wang R, Xu T, Lei X, Jin H, Gao X, Xie Y, Liu X, Zeng J
Neurochemical research 2023 Feb;48(2):519-536
Neurochemical research 2023 Feb;48(2):519-536
Cofilin promotes tau pathology in Alzheimer's disease.
Yan M, Tang L, Dai L, Lei C, Xiong M, Zhang X, He M, Tian Y, Xiong J, Ke W, Zhang Z, Zhang C, Deng X, Zhang Z
Cell reports 2023 Feb 28;42(2):112138
Cell reports 2023 Feb 28;42(2):112138
Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
Ma Z, Liu K, Zhang RF, Xie ZX, Liu W, Deng Y, Li X, Xu B
The Science of the total environment 2023 Feb 1;858(Pt 1):159753
The Science of the total environment 2023 Feb 1;858(Pt 1):159753
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
Zhang R, Mao W, Niu L, Bao W, Wang Y, Wang Y, Zhu Y, Yang Z, Chen J, Dong J, Cai M, Yuan Z, Song H, Li G, Zhang M, Xiong N, Wei J, Dong Z
eLife 2023 Apr 27;12
eLife 2023 Apr 27;12
Ursolic Acid Ameliorates Spinal Cord Injury in Mice by Regulating Gut Microbiota and Metabolic Changes.
Rong ZJ, Cai HH, Wang H, Liu GH, Zhang ZW, Chen M, Huang YL
Frontiers in cellular neuroscience 2022;16:872935
Frontiers in cellular neuroscience 2022;16:872935
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug design, development and therapy 2022;16:843-861
Drug design, development and therapy 2022;16:843-861
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice.
Xu Q, Xiong J, Xu L, Wu Y, Li M, Li Q, Jiang T, Luo A, Zhang Y
Frontiers in neuroscience 2022;16:824871
Frontiers in neuroscience 2022;16:824871
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity.
Li Y, Zhang Q, Yan W, Wang X, Yu J, Yin C, Zhou Q, Hou Z, Wang Q
Frontiers in aging neuroscience 2022;14:996223
Frontiers in aging neuroscience 2022;14:996223
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
Jin H, Yang C, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Environmental health perspectives 2022 Oct;130(10):107002
Environmental health perspectives 2022 Oct;130(10):107002
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
Zhang GJ, Zheng D, Yu H, Luo XP, Wu W
Current medical science 2022 Jun;42(3):474-482
Current medical science 2022 Jun;42(3):474-482
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Sun Z, Zhao S, Suo X, Dou Y
BMC neuroscience 2022 Jun 6;23(1):33
BMC neuroscience 2022 Jun 6;23(1):33
Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.
Ren Z, Wang M, Aldhabi M, Zhang R, Liu Y, Liu S, Tang R, Chen Z
Neurobiology of stress 2022 Jan;16:100422
Neurobiology of stress 2022 Jan;16:100422
sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway.
Lu L, Liu X, Fu J, Liang J, Hou Y, Dou H
Scientific reports 2022 Apr 29;12(1):7047
Scientific reports 2022 Apr 29;12(1):7047
Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury.
Luo W, Yang Z, Zhang W, Zhou D, Guo X, Wang S, He F, Wang Y
Frontiers in molecular neuroscience 2021;14:785938
Frontiers in molecular neuroscience 2021;14:785938
Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties.
Yu Z, Li D, Zhai S, Xu H, Liu H, Ao M, Zhao C, Jin W, Yu L
Food & function 2021 Oct 4;12(19):9211-9228
Food & function 2021 Oct 4;12(19):9211-9228
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Lu C, Liu X, Li J, Huang Y, Huang X, Dai G, Wu L
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
Electroacupuncture improves neuronal plasticity through the A2AR/cAMP/PKA signaling pathway in SNL rats.
Wu Q, Chen J, Yue J, Ying X, Zhou Y, Chen X, Tu W, Lou X, Yang G, Zhou K, Jiang S
Neurochemistry international 2021 May;145:104983
Neurochemistry international 2021 May;145:104983
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Xia B, Huang X, Sun G, Tao W
Journal of ethnopharmacology 2021 Mar 25;268:113665
Journal of ethnopharmacology 2021 Mar 25;268:113665
Hippocampal alpha-synuclein mediates depressive-like behaviors.
Du T, Li G, Luo H, Pan Y, Xu Q, Ma K
Brain, behavior, and immunity 2021 Jul;95:226-237
Brain, behavior, and immunity 2021 Jul;95:226-237
Proteomics Analysis of Brain Tissue in a Rat Model of Ischemic Stroke in the Acute Phase.
Zheng F, Zhou YT, Zeng YF, Liu T, Yang ZY, Tang T, Luo JK, Wang Y
Frontiers in molecular neuroscience 2020;13:27
Frontiers in molecular neuroscience 2020;13:27
Control the fate of human umbilical cord mesenchymal stem cells with dual-enzymatically cross-linked gelatin hydrogels for potential applications in nerve regeneration.
Li J, Gao F, Ma S, Zhang Y, Zhang J, Guan F, Yao M
Journal of tissue engineering and regenerative medicine 2020 Sep;14(9):1261-1271
Journal of tissue engineering and regenerative medicine 2020 Sep;14(9):1261-1271
Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease.
Yan M, Meng L, Dai L, Zhang X, Chen G, Zheng Y, Zha Y, Zeng Y, Zhang Z
Biochemical and biophysical research communications 2020 Sep 3;529(4):1053-1060
Biochemical and biophysical research communications 2020 Sep 3;529(4):1053-1060
Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.
Xie Q, Cheng J, Pan G, Wu S, Hu Q, Jiang H, Wang Y, Xiong J, Pang Q, Chen X
Experimental neurology 2019 Mar;313:60-78
Experimental neurology 2019 Mar;313:60-78
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
Wang Y, Liu Y, Li Y, Liu B, Wu P, Xu S, Shi H
Acta histochemica 2019 Jan;121(1):56-63
Acta histochemica 2019 Jan;121(1):56-63
iTRAQ-Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke.
Lin X, Liu T, Li P, He Z, Zhong Y, Cui H, Luo J, Wang Y, Tang T
BioMed research international 2018;2018:6920213
BioMed research international 2018;2018:6920213
High glucose-induced defective thrombospondin-1 release from astrocytes via TLR9 activation contributes to the synaptic protein loss.
Zhao Y, Pu D, Sun Y, Chen J, Luo C, Wang M, Zhou J, Lv A, Zhu S, Liao Z, Zhao K, Xiao Q
Experimental cell research 2018 Feb 15;363(2):171-178
Experimental cell research 2018 Feb 15;363(2):171-178
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SYN1-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SYN1-Specific. This antibody recognizes human, mouse antigen. The SYN1-Specific antibody has been validated for the following applications: ELISA, WB analysis.