25699-1-AP

antibody from Proteintech Group

Targeting: BDNF

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

25699-1-AP

Provider

Proteintech Group

Product name

BDNF antibody

Antibody type

Polyclonal

Description

KD/KO validated BDNF antibody (Cat. #25699-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Black mulberry anthocyanins induce antidepressant-like effects via the BDNF/TrkB signaling pathway.

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Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.

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NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.

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Journal of ethnopharmacology 2025 Jun 12;349:119960

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Probiotic L. reuteri treatment in stressed rats improves maternal care and corrects corticosterone-BDNF-oxytocin balance offering insights for maternal postpartum distress treatment.

Benlakehal R, Gaetano A, Charlet R, Bouwalerh H, Cogez V, Harduin-Lepers A, Sendid B, Nicoletti F, Maccari S, Morley-Fletcher S
Scientific reports 2025 Jul 2;15(1):23544

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Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats.

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Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mice.

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Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF.

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Stimulation of microglia leads to a rapid antidepressant effect by triggering astrocytic P2Y1Rs and promoting BDNF-mediated neurogenesis in the hippocampus.

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Frontiers in neuroscience 2024;18:1520710

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Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.

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Effects of Pain Relief Through Minimal Exercise Intervention in a Rat Model of Neuropathic Pain.

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Cureus 2024 Jun;16(6):e62897

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Light and classical music therapies attenuate chronic unpredictable mild stress-induced depression via BDNF signaling pathway in mice.

Cheng HY, Xie HX, Tang QL, Yi LT, Zhu JX
Heliyon 2024 Jul 15;10(13):e34196

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Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.

Zhang W, Zhong Y, Wang Z, Tang F, Zheng C
Scientific reports 2024 Jul 13;14(1):16215

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Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.

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Experimental and therapeutic medicine 2024 Feb;27(2):71

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Journal of psychiatric research 2024 Feb;170:262-276

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Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.

Xiaoyu L, Dandan L, Tianzhao O, Ziyou Z, Zhenlin L, Zhuang L, Mingrui L, Yusong H, Yangyang Z, Yanjiao L, Chun S, Siqi W, Tong L, Bensi Z
Scientific reports 2024 Dec 28;14(1):31447

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Spaccapaniccia E, Cazzorla T, Rossetti D, De Simone L, Antonangeli MI, Antonosante A, Galli F, Cattani F, Maffei M, Martin F
International journal of molecular sciences 2024 Dec 14;25(24)

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Yadav SK, Dhuri K, Gamiotea-Turro D, Cormier MK, Patel V, Yadawa AK, Pathuri M, Bahal R, Verma R
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Polygonatum sibiricum Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex.

Yuan ZY, Zhang X, Yu ZZ, Wang XY, Zeng ZH, Wei MX, Qiu MT, Wang J, Cheng J, Yi LT
Polymers 2024 Aug 20;16(16)

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CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.

Wu Y, Che J, Dong J, Zhang X, Deng Y, Chen W, Zhang J
Neuropharmacology 2024 Aug 15;254:109981

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The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.

Chen S, Xu Q, Zhao L, Zhang M, Xu H
Birth defects research 2024 Apr;116(4):e2336

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Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling.

Wang W, Li Y, Ma F, Sheng X, Chen K, Zhuo R, Wang C, Zheng H, Zhang YW, Bu G, Chen XF, Zhong L
Brain, behavior, and immunity 2023 Oct;113:275-288

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Ultrasound-targeted microbubbles destruction assists dual delivery of beta-amyloid antibody and neural stem cells to restore neural function in transgenic mice of Alzheimer's disease.

Zhu Q, Xu X, Chen B, Liao Y, Guan X, He Y, Cui H, Rong Y, Liu Z, Xu Y
Medical physics 2022 Mar;49(3):1357-1367

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CPEB3-dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice.

Lu WH, Chao HW, Lin PY, Lin SH, Liu TH, Chen HW, Huang YS
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1669-1679

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Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.

Srivastava P, Cronin CG, Scranton VL, Jacobson KA, Liang BT, Verma R
Experimental neurology 2020 Jul;329:113308

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Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression.

Zhu H, Wang Y, Yang X, Wan G, Qiu Y, Ye X, Gao Y, Wan D
American journal of translational research 2019;11(3):1311-1326

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Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.

Xia E, Xu F, Hu C, Kumal JPP, Tang X, Mao D, Li Y, Wu D, Zhang R, Wu S, Sun L
Neuroscience 2019 Oct 1;417:57-69

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Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE(-/-) mice via anti-inflammatory and BDNF-TrkB pathway.

Li L, Yu AL, Wang ZL, Chen K, Zheng W, Zhou JJ, Xie Q, Yan HB, Ren P, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893

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Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure mice through targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways.

Tang Q, Ke H, Wu C, Zeng J, Li Z, Liu Y, Feng S, Xue Q, Xu X
Journal of ethnopharmacology 2019 Jul 15;239:111925

---

Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.

Sun C, Fu J, Qu Z, Li D, Si P, Qiao Q, Zhang W, Xue Y, Zhen J, Wang W
Brain research 2019 Jul 1;1714:88-98

---

Ascorbic Acid Attenuates Lead-Induced Alterations in the Synapses in the Developing Rat Cerebellum.

Nam SM, Cho IS, Seo JS, Go TH, Kim JH, Nahm SS, Chang BJ, Lee JH
Biological trace element research 2019 Jan;187(1):142-150

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Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.

Belviranlı M, Okudan N
Neuromolecular medicine 2018 Sep;20(3):386-400

---

Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats.

Lu Y, Ho CS, McIntyre RS, Wang W, Ho RC
Brain research bulletin 2018 Sep;142:1-7

---

Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.

Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97

---

Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus.

Lu Y, Ho CS, McIntyre RS, Wang W, Ho RC
Life sciences 2018 Oct 1;210:177-184

---

Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.

Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G
Cellular and molecular life sciences : CMLS 2018 Jul;75(13):2473-2488

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miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway.

Gu X, Fu C, Lin L, Liu S, Su X, Li A, Wu Q, Jia C, Zhang P, Chen L, Zhu X, Wang X
Journal of cellular physiology 2018 Jan;233(1):673-687

---

Long-term moderate exercise enhances specific proteins that constitute neurotrophin signaling pathway: A TMT-based quantitative proteomic analysis of rat plasma.

Wei Y, Fang CL, Liu SJ, Yang WQ, Wei LS, Lei XJ, Hu F, Huang HY, Li W, Chen W, Li LM, Long YS
Journal of proteomics 2018 Aug 15;185:39-50

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MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.

Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH
Gene therapy 2018 Apr;25(2):104-114

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Astrocytes mediated the nootropic and neurotrophic effects of Sarsasapogenin-AA13 via upregulating brain-derived neurotrophic factor.

Dong D, Mao Y, Huang C, Jiao Q, Pan H, Ma L, Wang R
American journal of translational research 2017;9(9):4015-4025

---

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds.

Zhang X, Zheng W, Wang T, Ren P, Wang F, Ma X, Wang J, Huang X
Frontiers in pharmacology 2017;8:452

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Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.

Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z
BioMed research international 2017;2017:7464872

---

Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis.

Cui M, Xiao H, Li Y, Dong J, Luo D, Li H, Feng G, Wang H, Fan S
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2333-2341

---

The Role of Endogenous Neurogenesis in Functional Recovery and Motor Map Reorganization Induced by Rehabilitative Therapy after Stroke in Rats.

Shiromoto T, Okabe N, Lu F, Maruyama-Nakamura E, Himi N, Narita K, Yagita Y, Kimura K, Miyamoto O
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Feb;26(2):260-272

---

Human Umbilical Cord Mesenchymal Stem Cells Overexpressing Nerve Growth Factor Ameliorate Diabetic Cystopathy in Rats.

WenBo W, Fei Z, YiHeng D, Wei W, TingMang Y, WenHao Z, QianRu L, HaiTao L
Neurochemical research 2017 Dec;42(12):3537-3547

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Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury.

Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski MH
Journal of neurotrauma 2016 Jun 15;33(12):1103-14

---

Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.

Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR
PloS one 2015;10(8):e0136255

---

SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.

Hong ZY, Yu SS, Wang ZJ, Zhu YZ
International journal of molecular sciences 2015 Aug 7;16(8):18544-63

---

Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.

Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X, Zhao J
Neuropharmacology 2014 Apr;79:282-9

---

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.

Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 25;33(39):15596-602

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

fetal human brain tissue were subjected to SDS PAGE followed by western blot with 25699-1-AP( BDNF Antibody) at dilution of 1:300

Other comments

WB

Appendix

25699-1-AP.pdf

Show more

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemistry of paraffin-embedded human testis tissue slide using 25699-1-AP( BDNF Antibody) at dilution of 1:50 (under 10x lens)

Other comments

IHC

Appendix

25699-1-AP.pdf

Show more