CABT-B4843

antibody from Creative Diagnostics

Targeting: BDNF

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-B4843

Provider

Creative Diagnostics

Product name

Anti-BDNF monoclonal antibody, clone 37141

Antibody type

Monoclonal

Description

Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer.BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor.

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

37141

Vial size

100_g

Storage

12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution.6 months, -20 to -70°C under sterile conditions after reconstitution.