Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations [0]
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- Product number
- 28205-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BDNF antibody
- Antibody type
- Polyclonal
- Description
- BDNF antibody (Cat. #28205-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.
Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice.
Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota.
Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice.
The protective function of taurine on pesticide-induced permanent neurodevelopmental toxicity in juvenile rats.
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Meranzin hydrate elicits antidepressant effects and restores reward circuitry.
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes.
Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro.
Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.
IRF8 is crucial for the nicotine withdrawal-induced hyperalgesia in mice.
PKA-Dependent Membrane Surface Recruitment of CI-AMPARs Is Crucial for BCP-Mediated Protection Against Post-acute Ischemic Stroke Cognitive Impairment.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation.
Colocalization of dopamine receptors in BDNF-expressing peptidergic neurons in the paraventricular nucleus of rats.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus.
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.
Apelin-13 ameliorates chronic water-immersion restraint stress-induced memory performance deficit through upregulation of BDNF in rats.
Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.
Improvement of motor function induced by skeletal muscle contraction in spinal cord-injured rats.
Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models.
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions.
Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Zhang L, Zhang Y, Zhu M, Pei L, Deng F, Chen J, Zhang S, Cong Z, Du W, Xiao X
Frontiers in pharmacology 2021;12:590602
Frontiers in pharmacology 2021;12:590602
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Lu C, Liu X, Li J, Huang Y, Huang X, Dai G, Wu L
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Guo H, Deji C, Peng H, Zhang J, Chen Y, Zhang Y, Wang Y
Genes, brain, and behavior 2021 Nov;20(8):e12765
Genes, brain, and behavior 2021 Nov;20(8):e12765
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Zhang Y, Zhou L, Lian H, Zhang Y, Tong S, Wang Z
Journal of chemical neuroanatomy 2021 Nov;117:102016
Journal of chemical neuroanatomy 2021 Nov;117:102016
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Yao H, Shen H, Yu H, Wang C, Ding R, Lan X, Tash D, Wu X, Wang X, Zhang G
Physiology & behavior 2021 May 15;234:113387
Physiology & behavior 2021 May 15;234:113387
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.
Verhaeghe R, Gao V, Morley-Fletcher S, Bouwalerh H, Van Camp G, Cisani F, Nicoletti F, Maccari S
GeroScience 2021 May 13;
GeroScience 2021 May 13;
Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice.
Luong H, Singh S, Patil M, Krishnamurthy P
American journal of physiology. Heart and circulatory physiology 2021 May 1;320(5):H2044-H2057
American journal of physiology. Heart and circulatory physiology 2021 May 1;320(5):H2044-H2057
Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota.
Lin S, Li Q, Jiang S, Xu Z, Jiang Y, Liu L, Jiang J, Tong Y, Wang P
Journal of ethnopharmacology 2021 Mar 25;268:113608
Journal of ethnopharmacology 2021 Mar 25;268:113608
Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice.
Liu X, Hou M, Zhang S, Zhao Y, Wang Q, Jiang M, Du M, Shao Z, Yuan H
Cell death & disease 2021 Jun 15;12(6):613
Cell death & disease 2021 Jun 15;12(6):613
The protective function of taurine on pesticide-induced permanent neurodevelopmental toxicity in juvenile rats.
Liu F, Yuan M, Li C, Guan X, Li B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21273
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21273
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, Li JF, Shi SQ, Ren P, Huang X
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Ying X, Xie Q, Yu X, Li S, Wu Q, Chen X, Yue J, Zhou K, Tu W, Jiang S
Neurochemistry international 2021 Feb;143:104945
Neurochemistry international 2021 Feb;143:104945
Meranzin hydrate elicits antidepressant effects and restores reward circuitry.
Liu X, Zhou J, Zhang T, Chen K, Xu M, Wu L, Liu J, Huang Y, Nie B, Shen X, Ren P, Huang X
Behavioural brain research 2021 Feb 1;398:112898
Behavioural brain research 2021 Feb 1;398:112898
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Huang S, Tan Z, Cai J, Wang Z, Tian Y
Pharmaceutical biology 2021 Dec;59(1):584-593
Pharmaceutical biology 2021 Dec;59(1):584-593
Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes.
Fu X, Zhou G, Wu X, Xu C, Zhou H, Zhuang J, Peng Y, Cao Y, Zeng H, Li Y, Li J, Gao L, Chen G, Wang L, Yan F
Journal of neuroinflammation 2021 Aug 23;18(1):184
Journal of neuroinflammation 2021 Aug 23;18(1):184
Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro.
Sun J, Yuan B, Wu Y, Gong Y, Guo W, Fu S, Luan Y, Wang W
Mediators of inflammation 2020;2020:7605160
Mediators of inflammation 2020;2020:7605160
Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.
Xu L, Zheng YL, Yin X, Xu SJ, Tian D, Zhang CY, Wang S, Ma JZ
Frontiers in molecular neuroscience 2020;13:7
Frontiers in molecular neuroscience 2020;13:7
IRF8 is crucial for the nicotine withdrawal-induced hyperalgesia in mice.
Guo L, Zhang Y, Wang J, Qi Y, Zhang Z
Translational neuroscience 2020;11(1):283-293
Translational neuroscience 2020;11(1):283-293
PKA-Dependent Membrane Surface Recruitment of CI-AMPARs Is Crucial for BCP-Mediated Protection Against Post-acute Ischemic Stroke Cognitive Impairment.
Chen S, Wang Y, Wang X, He M, Zhang L, Dong Z
Frontiers in neurology 2020;11:566067
Frontiers in neurology 2020;11:566067
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation.
Zhang B, Zhao J, Wang Z, Xu L, Liu A, Du G
International immunopharmacology 2020 Sep;86:106729
International immunopharmacology 2020 Sep;86:106729
Colocalization of dopamine receptors in BDNF-expressing peptidergic neurons in the paraventricular nucleus of rats.
Zhou L, Zhang Y, Lian H, Li Y, Wang Z
Journal of chemical neuroanatomy 2020 Jul;106:101794
Journal of chemical neuroanatomy 2020 Jul;106:101794
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204
Scientific reports 2020 Dec 17;10(1):22204
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug design, development and therapy 2019;13:4145-4157
Drug design, development and therapy 2019;13:4145-4157
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
He Z, Yu L, Luo S, Li Q, Huang S, An Y
OncoTargets and therapy 2019;12:8701-8714
OncoTargets and therapy 2019;12:8701-8714
Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus.
Kim W, Hahn KR, Jung HY, Kwon HJ, Nam SM, Kim JW, Park JH, Yoo DY, Kim DW, Won MH, Yoon YS, Hwang IK
Brain and behavior 2019 Sep;9(9):e01388
Brain and behavior 2019 Sep;9(9):e01388
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet.
Xu J, Gao H, Zhang L, Rong S, Yang W, Ma C, Chen M, Huang Q, Deng Q, Huang F
Journal of pineal research 2019 Sep;67(2):e12584
Journal of pineal research 2019 Sep;67(2):e12584
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.
Buck JM, O'Neill HC, Stitzel JA
Biochemical pharmacology 2019 Oct;168:438-451
Biochemical pharmacology 2019 Oct;168:438-451
Apelin-13 ameliorates chronic water-immersion restraint stress-induced memory performance deficit through upregulation of BDNF in rats.
Shen P, Yue Q, Fu W, Tian SW, You Y
Neuroscience letters 2019 Mar 23;696:151-155
Neuroscience letters 2019 Mar 23;696:151-155
Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.
Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ, Yang GY
CNS neuroscience & therapeutics 2019 Jun;25(6):748-758
CNS neuroscience & therapeutics 2019 Jun;25(6):748-758
Improvement of motor function induced by skeletal muscle contraction in spinal cord-injured rats.
Hayashi N, Himi N, Nakamura-Maruyama E, Okabe N, Sakamoto I, Hasegawa T, Miyamoto O
The spine journal : official journal of the North American Spine Society 2019 Jun;19(6):1094-1105
The spine journal : official journal of the North American Spine Society 2019 Jun;19(6):1094-1105
Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models.
Kim GH, Lim K, Yang HS, Lee JK, Kim Y, Park SK, Kim SH, Park S, Kim TH, Moon JS, Hwang IK, Yoon YS, Seo HS, Nam SM, Kim MY, Yoon SG, Seong JK, Yi SS
Journal of chemical neuroanatomy 2019 Jul;98:27-40
Journal of chemical neuroanatomy 2019 Jul;98:27-40
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
Ying X, Tu W, Li S, Wu Q, Chen X, Zhou Y, Hu J, Yang G, Jiang S
Life sciences 2019 Jul 15;229:187-199
Life sciences 2019 Jul 15;229:187-199
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
Wang Y, Liu Y, Li Y, Liu B, Wu P, Xu S, Shi H
Acta histochemica 2019 Jan;121(1):56-63
Acta histochemica 2019 Jan;121(1):56-63
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
Gong Q, Yan XJ, Lei F, Wang ML, He LL, Luo YY, Gao HW, Feng YL, Yang SL, Li J, Du LJ
Molecular brain 2019 Dec 30;12(1):118
Molecular brain 2019 Dec 30;12(1):118
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A
Autophagy 2019 Apr;15(4):631-651
Autophagy 2019 Apr;15(4):631-651
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Zhang X, Li X, Liu N, Zheng P, Ma L, Guo F, Sun T, Zhou R, Yu J
Molecules (Basel, Switzerland) 2019 Apr 24;24(8)
Molecules (Basel, Switzerland) 2019 Apr 24;24(8)
Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions.
Dai TT, Wang B, Xiao ZY, You Y, Tian SW
Neuroscience 2018 Oct 15;390:151-159
Neuroscience 2018 Oct 15;390:151-159
Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus.
Kwon HJ, Jung HY, Hahn KR, Kim W, Kim JW, Yoo DY, Yoon YS, Hwang IK, Kim DW
Laboratory animal research 2018 Dec;34(4):239-247
Laboratory animal research 2018 Dec;34(4):239-247
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