HPA023696

antibody from Atlas Antibodies

Targeting: GCLM GLCLR

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA023696

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA023696, RRID:AB_1849560

Product name

Anti-GCLM

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human GCLM, Gene description: glutamate-cysteine ligase, modifier subunit, Alternative Gene Names: GLCLR, Validated applications: ICC, IHC, WB, Uniprot ID: P48507, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.

Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB
Nature communications 2022 Feb 8;13(1):745

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Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma

DEQUANTER D, VAN DE VELDE M, BAR I, NUYENS V, ROUSSEAU A, NAGY N, VANHAMME L, VANHAEVERBEEK M, BROHÉE D, DELRÉE P, BOUDJELTIA K, LOTHAIRE P, UZUREAU P
Oncology Letters 2016;11(6):3660-3668

Immunocytochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.

Sample type

Human