Antibody data
- Antibody Data
- Antigen structure
- References [131]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14241-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14241-1-AP, RRID:AB_2107832
- Product name
- GCLM antibody
- Antibody type
- Polyclonal
- Description
- GCLM antibody (Cat. #14241-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia.
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination.
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Natural Variation in Age-Related Dopamine Neuron Degeneration is Glutathione-Dependent and Linked to Life Span.
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway.
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway.
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells.
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
IRF5 knockdown reverses TDP-related phenotypes partially by increasing TBK1 expression.
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Human hematopoietic stem cell vulnerability to ferroptosis.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells.
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes.
Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse.
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
PrP(Sc) Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways.
Cysteine is a limiting factor for glioma proliferation and survival.
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Action of the Nrf2/ARE signaling pathway on oxidative stress in choroid plexus epithelial cells following lanthanum chloride treatment.
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress.
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
hPMSCs inhibit the expression of PD-1 in CD4(+)IL-10(+) T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.
Blockade of Glutathione Metabolism in IDH1-Mutated Glioma.
Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.
FSHR ablation induces depression-like behaviors.
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
SIRT2, ERK and Nrf2 Mediate NAD(+) Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions.
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.
Characterization of natural melanin from Auricularia auricula and its hepatoprotective effect on acute alcohol liver injury in mice.
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Bioavailable Blueberry-Derived Phenolic Acids at Physiological Concentrations Enhance Nrf2-Regulated Antioxidant Responses in Human Vascular Endothelial Cells.
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells.
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Progesterone amplifies oxidative stress signal and promotes NO production via H2O2 in mouse kidney arterial endothelial cells.
15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.
Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver.
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Guan T, Li N, Xu X, Xiong D, Wang B, Xiao L, Yang W, Chu G, Yusuf A, Zhang J, Yue W
Archives of biochemistry and biophysics 2024 Mar;753:109928
Archives of biochemistry and biophysics 2024 Mar;753:109928
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Miao L, Wang ST, Wei QH, Ma RF, Zhang H
Phytochemistry 2024 Mar;219:113984
Phytochemistry 2024 Mar;219:113984
Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia.
Wang Y, Zhou X, Yao L, Hu Q, Liu H, Zhao G, Wang K, Zeng J, Sun M, Lv C
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2306916
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2306916
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Zhang H, Chen Q, Han H, Guo C, Jiang X, Xia Y, Zhang Y, Zhou L, Zhang J, Tian X, Mao L, Qiu J, Zou Z, Chen C
Journal of hazardous materials 2024 Jul 5;472:134440
Journal of hazardous materials 2024 Jul 5;472:134440
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Qi XY, Peng GC, Han QT, Yan J, Chen LZ, Wang T, Xu LT, Liu MJ, Xu ZP, Wang XN, Shen T
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Xiao Y, Duan C, Gong P, Zhao Q, Wang XH, Geng F, Zeng J, Luo T, Xu Y, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Li XN, Shang NY, Kang YY, Sheng N, Lan JQ, Tang JS, Wu L, Zhang JL, Peng Y
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination.
Mao M, Xia Q, Zhan G, Bing H, Zhang C, Wang J, Tian W, Lian H, Li X, Chu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155304
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155304
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Liu CX, Gao Y, Xu XF, Jin X, Zhang Y, Xu Q, Ding HX, Li BJ, Du FK, Li LC, Zhong MW, Zhu JK, Zhang GY
World journal of gastroenterology 2024 Feb 7;30(5):485-498
World journal of gastroenterology 2024 Feb 7;30(5):485-498
Natural Variation in Age-Related Dopamine Neuron Degeneration is Glutathione-Dependent and Linked to Life Span.
Coleman CR, Pallos J, Arreola-Bustos A, Wang L, Raftery D, Promislow DEL, Martin I
bioRxiv : the preprint server for biology 2024 Feb 14;
bioRxiv : the preprint server for biology 2024 Feb 14;
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70
Cell death discovery 2024 Feb 10;10(1):70
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway.
Qiu C, Li Z, Peng P
Regenerative therapy 2024 Dec;27:1-11
Regenerative therapy 2024 Dec;27:1-11
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T
Journal of gastroenterology 2024 Aug;59(8):682-698
Journal of gastroenterology 2024 Aug;59(8):682-698
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914
Mechanisms of ageing and development 2024 Apr;218:111914
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T
Journal of gastroenterology 2023 Sep;58(9):868-882
Journal of gastroenterology 2023 Sep;58(9):868-882
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Zhou W, He H, Wei Q, Che L, Zhao X, Liu W, Yan Y, Hu L, Du Y, Yin Z, Shuai Y, Yang L, Feng R
Food science & nutrition 2023 Oct;11(10):6604-6615
Food science & nutrition 2023 Oct;11(10):6604-6615
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;
bioRxiv : the preprint server for biology 2023 Oct 11;
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
Yuan Z, Li J, Zou X, Liu C, Lu J, Ni C, Tang L, Wu X, Yan F
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Yu H, Yan S, Jin M, Wei Y, Zhao L, Cheng J, Ding L, Feng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154746
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154746
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Zhang X, Cui K, Wang X, Tong Y, Liu C, Zhu Y, You Q, Jiang Z, Guo X
Antioxidants (Basel, Switzerland) 2023 May 8;12(5)
Antioxidants (Basel, Switzerland) 2023 May 8;12(5)
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Shao D, Shen W, Miao Y, Gao Z, Pan M, Wei Q, Yan Z, Zhao X, Ma B
Journal of animal science and biotechnology 2023 May 3;14(1):61
Journal of animal science and biotechnology 2023 May 3;14(1):61
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway.
Li Z, Gu Z, Wang L, Guan Y, Lyu Y, Zhang J, Wang Y, Wang X, Xiong J, Liu Y
International journal of molecular sciences 2023 May 27;24(11)
International journal of molecular sciences 2023 May 27;24(11)
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456
ACS central science 2023 Mar 22;9(3):440-456
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Qi H, Shi H, Yan M, Zhao L, Yin Y, Tan X, Qi H, Li H, Weng K, Tang Y, Dai Y
Cell death discovery 2023 Jul 25;9(1):259
Cell death discovery 2023 Jul 25;9(1):259
Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells.
Nguyen V, Kravitz J, Gao C, Hochman ML, Meng D, Chen D, Wang Y, Jegga AG, Nelson JS, Tan W
bioRxiv : the preprint server for biology 2023 Jul 19;
bioRxiv : the preprint server for biology 2023 Jul 19;
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Shao D, Gao Z, Zhao Y, Fan M, Zhao X, Wei Q, Pan M, Ma B
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
IRF5 knockdown reverses TDP-related phenotypes partially by increasing TBK1 expression.
Li Y, Yu L, Liu C, Duan W, Zhang S, Li Z, Yi L, Guo M, Bi Y, Li C, Liu Y
Brain research 2023 Jan 1;1798:148155
Brain research 2023 Jan 1;1798:148155
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Tang S, Zhang H, Xia Y, Luo S, Liu Y, Duan X, Zou Z, Chen C, Zhou L, Qiu J
Toxicology mechanisms and methods 2023 Feb;33(2):113-122
Toxicology mechanisms and methods 2023 Feb;33(2):113-122
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Huang B, Hu G, Zong X, Yang S, He D, Gao X, Liu D
International immunopharmacology 2023 Feb;115:109698
International immunopharmacology 2023 Feb;115:109698
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Zhang M, Zhang J, Zhu QM, Zhao WY, Lv X, Yi J, Huo XK, Wang MJ, Sun CP
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
Human hematopoietic stem cell vulnerability to ferroptosis.
Zhao J, Jia Y, Mahmut D, Deik AA, Jeanfavre S, Clish CB, Sankaran VG
Cell 2023 Feb 16;186(4):732-747.e16
Cell 2023 Feb 16;186(4):732-747.e16
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.
Yang Y, Liu Z, Wu J, Bao S, Wang Y, Li J, Song T, Sun Y, Pi J
Antioxidants (Basel, Switzerland) 2023 Dec 10;12(12)
Antioxidants (Basel, Switzerland) 2023 Dec 10;12(12)
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Wu N, Zhu D, Li J, Li X, Zhu Z, Rao Q, Hu B, Wang H, Zhu Y
Journal of endocrinological investigation 2023 Aug;46(8):1573-1587
Journal of endocrinological investigation 2023 Aug;46(8):1573-1587
Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells.
Nguyen V, Kravitz J, Gao C, Hochman ML, Meng D, Chen D, Wang Y, Jegga AG, Nelson JS, Tan W
Metabolites 2023 Aug 31;13(9)
Metabolites 2023 Aug 31;13(9)
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.
Xu Z, Zhang M, Wang W, Zhou S, Yu M, Qiu X, Jiang S, Wang X, Tang C, Li S, Wang CH, Zhu R, Peng WX, Zhao L, Fu X, Patzak A, Persson PB, Zhao L, Mao J, Shu Q, Lai EY, Zhang G
Toxicology and applied pharmacology 2023 Aug 15;473:116595
Toxicology and applied pharmacology 2023 Aug 15;473:116595
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Miao B, Zheng J, Zheng G, Tian X, Zhang W, Yuan F, Yang Z
Frontiers in nutrition 2022;9:798708
Frontiers in nutrition 2022;9:798708
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Baogui XU, Jiawen Z, Xiaoxiao T, Falei Y, Zhongliang L, Zuisu Y, Xianjun D
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes.
Wijaya LS, Rau C, Braun TS, Marangoz S, Spegg V, Vlasveld M, Albrecht W, Brecklinghaus T, Kamp H, Beltman JB, Hengstler JG, van de Water B, Leist M, Schildknecht S
Cell biology and toxicology 2022 Oct;38(5):847-864
Cell biology and toxicology 2022 Oct;38(5):847-864
Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse.
Koike S, Sato K, Sawa M, Inaba Y, Hattori K, Nakadate K, Ushiyama A, Ogasawara Y
Antioxidants (Basel, Switzerland) 2022 Nov 25;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 25;11(12)
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, Zhao X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
PrP(Sc) Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways.
Yang W, Chen C, Chen J, Xia Y, Hu C, Wang L, Wu YZ, Shi Q, Chen ZB, Dong XP
Molecular neurobiology 2022 May;59(5):3310-3321
Molecular neurobiology 2022 May;59(5):3310-3321
Cysteine is a limiting factor for glioma proliferation and survival.
Ruiz-Rodado V, Dowdy T, Lita A, Kramp T, Zhang M, Jung J, Dios-Esponera A, Zhang L, Herold-Mende CC, Camphausen K, Gilbert MR, Larion M
Molecular oncology 2022 May;16(9):1777-1794
Molecular oncology 2022 May;16(9):1777-1794
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Li J, Gao Y, Cui L, He H, Zheng J, Mo S, Zhou X, Chu S, Sun X, Chen N, Wang H
The Journal of pharmacy and pharmacology 2022 May 20;74(5):730-739
The Journal of pharmacy and pharmacology 2022 May 20;74(5):730-739
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Rom O, Liu Y, Finney AC, Ghrayeb A, Zhao Y, Shukha Y, Wang L, Rajanayake KK, Das S, Rashdan NA, Weissman N, Delgadillo L, Wen B, Garcia-Barrio MT, Aviram M, Kevil CG, Yurdagul A Jr, Pattillo CB, Zhang J, Sun D, Hayek T, Gottlieb E, Mor I, Chen YE
Redox biology 2022 Jun;52:102313
Redox biology 2022 Jun;52:102313
Action of the Nrf2/ARE signaling pathway on oxidative stress in choroid plexus epithelial cells following lanthanum chloride treatment.
Sun J, Zhang Y, Yan L, Liu S, Wang W, Zhu Y, Wang W, Li S, He B, Wu L, Zhang L
Journal of inorganic biochemistry 2022 Jun;231:111792
Journal of inorganic biochemistry 2022 Jun;231:111792
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
Zhang L, Zhang Y, Qin X, Jiang X, Zhang J, Mao L, Jiang Z, Jiang Y, Liu G, Qiu J, Chen C, Qiu F, Zou Z
Critical care (London, England) 2022 Jun 9;26(1):171
Critical care (London, England) 2022 Jun 9;26(1):171
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
Carreño M, Pires MF, Woodcock SR, Brzoska T, Ghosh S, Salvatore SR, Chang F, Khoo NKH, Dunn M, Connors N, Yuan S, Straub AC, Wendell SG, Kato GJ, Freeman BA, Ofori-Acquah SF, Sundd P, Schopfer FJ, Vitturi DA
Science advances 2022 Jul;8(26):eabm9138
Science advances 2022 Jul;8(26):eabm9138
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Zhang J, Zhang M, Zhang WH, Zhu QM, Huo XK, Sun CP, Ma XC, Xiao HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Zhang J, Zhang M, Zhang WH, Zhu QM, Ning J, Huo XK, Xiao HT, Sun CP
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Wu XY, Wang T, Hu HX, Zhang K, Zhao Y, Zhao BB, Lou HX, Wang XN, Shen T
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Guo T, Fang X, Liu Y, Ruan Y, Hu Y, Wang X, Hu Y, Wang G, Xu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
CREB1 and ATF1 Negatively Regulate Glutathione Biosynthesis Sensitizing Cells to Oxidative Stress.
Zhao L, Xia W, Jiang P
Frontiers in cell and developmental biology 2021;9:698264
Frontiers in cell and developmental biology 2021;9:698264
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Liao ZQ, Jiang YN, Su ZL, Bi HL, Li JT, Li CL, Yang XL, Zhang Y, Xie X
Frontiers in cardiovascular medicine 2021;8:809689
Frontiers in cardiovascular medicine 2021;8:809689
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S, Zhang G
Oxidative medicine and cellular longevity 2021;2021:8869908
Oxidative medicine and cellular longevity 2021;2021:8869908
Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats.
Hu X, Mu L, Zhu L, Chang X, Nie L, Wang L, Li G
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
hPMSCs inhibit the expression of PD-1 in CD4(+)IL-10(+) T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Zhang A, Zhang J, Li X, Zhang H, Xiong Y, Wang Z, Zhao N, Wang F, Luan X
Stem cell research & therapy 2021 Jun 29;12(1):368
Stem cell research & therapy 2021 Jun 29;12(1):368
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Zhu Z, Hu R, Li J, Xing X, Chen J, Zhou Q, Sun J
International immunopharmacology 2021 Jul;96:107660
International immunopharmacology 2021 Jul;96:107660
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Martinez R 3rd, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Deng J, Huang M, Wu H
Bioengineered 2021 Dec;12(1):7975-7984
Bioengineered 2021 Dec;12(1):7975-7984
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Feng X, Jiang T, Yang C, Pang S, Ding Z, Hu H, Wang H, Dong L, Yang N
Cell death & disease 2021 Dec 17;13(1):6
Cell death & disease 2021 Dec 17;13(1):6
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Guo S, Yang J, Qin J, Qazi IH, Pan B, Zang S, Lv T, Deng S, Fang Y, Zhou G
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Wang M, Liu CY, Wang T, Yu HM, Ouyang SH, Wu YP, Gong HB, Ma XH, Jiao GL, Fu LL, Wu QS, Kurihara H, Li YF, Shen T, He RR
Cell death & disease 2020 Sep 19;11(9):781
Cell death & disease 2020 Sep 19;11(9):781
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW, Reddy SP
Scientific reports 2020 Nov 4;10(1):19034
Scientific reports 2020 Nov 4;10(1):19034
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.
Hou X, Xu H, Chen W, Zhang N, Zhao Z, Fang X, Zhang X, Chen H, Xu Y
Annals of translational medicine 2020 Mar;8(6):375
Annals of translational medicine 2020 Mar;8(6):375
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Wang S, Cheng H, Wang L, Zhao R, Guan D
International journal of molecular sciences 2020 Mar 16;21(6)
International journal of molecular sciences 2020 Mar 16;21(6)
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.
Lu M, Zhang X, Zhao J, You Q, Jiang Z
Redox biology 2020 Jul;34:101565
Redox biology 2020 Jul;34:101565
Blockade of Glutathione Metabolism in IDH1-Mutated Glioma.
Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C
Molecular cancer therapeutics 2020 Jan;19(1):221-230
Molecular cancer therapeutics 2020 Jan;19(1):221-230
Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.
Lee JJ, Ishihara K, Notomi S, Efstathiou NE, Ueta T, Maidana D, Chen X, Iesato Y, Caligiana A, Vavvas DG
Biochemical and biophysical research communications 2020 Jan 8;521(2):414-419
Biochemical and biophysical research communications 2020 Jan 8;521(2):414-419
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Liu Y, Pang Y, Caisova V, Ding J, Yu D, Zhou Y, Huynh TT, Ghayee H, Pacak K, Yang C
Cancers 2020 Jan 23;12(2)
Cancers 2020 Jan 23;12(2)
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.
Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, Yao H, Song N, Ding X, Ding J, Xiao M, Hu G
Nature communications 2020 Feb 18;11(1):941
Nature communications 2020 Feb 18;11(1):941
FSHR ablation induces depression-like behaviors.
Bi WK, Shao SS, Li ZW, Ruan YW, Luan SS, Dong ZH, Wang J, Wu SS, Guo T, Ma SZ, Gao L, Zhao JJ, He Z
Acta pharmacologica Sinica 2020 Aug;41(8):1033-1040
Acta pharmacologica Sinica 2020 Aug;41(8):1033-1040
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Yang WJ, Chen XM, Wang SQ, Hu HX, Cheng XP, Xu LT, Ren DM, Wang XN, Zhao BB, Lou HX, Shen T
Journal of natural products 2020 Apr 24;83(4):1217-1228
Journal of natural products 2020 Apr 24;83(4):1217-1228
SIRT2, ERK and Nrf2 Mediate NAD(+) Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions.
Zhang J, Hong Y, Cao W, Yin S, Shi H, Ying W
Frontiers in molecular neuroscience 2019;12:108
Frontiers in molecular neuroscience 2019;12:108
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Lu MC, Zhao J, Liu YT, Liu T, Tao MM, You QD, Jiang ZY
Redox biology 2019 Sep;26:101266
Redox biology 2019 Sep;26:101266
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
Zheng J, Tian X, Zhang W, Zheng P, Huang F, Ding G, Yang Z
Marine drugs 2019 Sep 27;17(10)
Marine drugs 2019 Sep 27;17(10)
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Yang WJ, He JX, Zhou MX, Huang M, Wang SQ, Wang XN, Lou HX, Ren DM, Shen T
Free radical research 2019 Mar;53(3):348-358
Free radical research 2019 Mar;53(3):348-358
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Peng L, Zhao Y, Li Y, Zhou Y, Li L, Lei S, Yu S, Zhao Y
Journal of molecular medicine (Berlin, Germany) 2019 Feb;97(2):189-199
Journal of molecular medicine (Berlin, Germany) 2019 Feb;97(2):189-199
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.
Jobbagy S, Vitturi DA, Salvatore SR, Turell L, Pires MF, Kansanen E, Batthyany C, Lancaster JR Jr, Freeman BA, Schopfer FJ
Redox biology 2019 Feb;21:101050
Redox biology 2019 Feb;21:101050
Characterization of natural melanin from Auricularia auricula and its hepatoprotective effect on acute alcohol liver injury in mice.
Hou R, Liu X, Yan J, Xiang K, Wu X, Lin W, Chen G, Zheng M, Fu J
Food & function 2019 Feb 20;10(2):1017-1027
Food & function 2019 Feb 20;10(2):1017-1027
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Betharia S, Rondόn-Ortiz AN, Brown DA
Neurochemical research 2019 Aug;44(8):1878-1892
Neurochemical research 2019 Aug;44(8):1878-1892
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Li YR, Li GH, Sun L, Li L, Liu Y, Kong DG, Wang SQ, Ren DM, Wang XN, Lou HX, Shen T
Oxidative medicine and cellular longevity 2018;2018:7616852
Oxidative medicine and cellular longevity 2018;2018:7616852
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Wei X, Mo X, An F, Ji X, Lu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Sep;119:252-259
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Sep;119:252-259
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Richardson BG, Jain AD, Potteti HR, Lazzara PR, David BP, Tamatam CR, Choma E, Skowron K, Dye K, Siddiqui Z, Wang YT, Krunic A, Reddy SP, Moore TW
Journal of medicinal chemistry 2018 Sep 13;61(17):8029-8047
Journal of medicinal chemistry 2018 Sep 13;61(17):8029-8047
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Bioavailable Blueberry-Derived Phenolic Acids at Physiological Concentrations Enhance Nrf2-Regulated Antioxidant Responses in Human Vascular Endothelial Cells.
Tang JS, Vissers MCM, Anderson RF, Sreebhavan S, Bozonet SM, Scheepens A, Melton LD
Molecular nutrition & food research 2018 Mar;62(5)
Molecular nutrition & food research 2018 Mar;62(5)
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Sun Y, Li TY, Song L, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury.
Lv W, Deng B, Duan W, Li Y, Liu Y, Li Z, Xia W, Li C
Neuroscience 2018 Jul 1;382:1-13
Neuroscience 2018 Jul 1;382:1-13
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.
Yuan XH, Yang CR, Wang XN, Zhang LL, Gao XR, Shi ZY
Journal of cellular physiology 2018 Jan;234(1):709-720
Journal of cellular physiology 2018 Jan;234(1):709-720
3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells.
Tomiyama R, Takakura K, Takatou S, Le TM, Nishiuchi T, Nakamura Y, Konishi T, Matsugo S, Hori O
Journal of cellular physiology 2018 Feb;233(2):1671-1684
Journal of cellular physiology 2018 Feb;233(2):1671-1684
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Yang WJ, Li YR, Gao H, Wu XY, Wang XL, Wang XN, Xiang L, Ren DM, Lou HX, Shen T
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, Zhao L, Wang X, Chen Z
Free radical research 2016;50(11):1200-1213
Free radical research 2016;50(11):1200-1213
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, Chen Y
Journal of hematology & oncology 2016 Sep 6;9(1):83
Journal of hematology & oncology 2016 Sep 6;9(1):83
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093
Scientific reports 2016 May 19;6:26093
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Yu G, Deng A, Tang W, Ma J, Yuan C, Ma J
Neurochemistry international 2016 Jun;96:113-20
Neurochemistry international 2016 Jun;96:113-20
SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells.
Cao W, Hong Y, Chen H, Wu F, Wei X, Ying W
FEBS letters 2016 Jul;590(14):2241-55
FEBS letters 2016 Jul;590(14):2241-55
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Progesterone amplifies oxidative stress signal and promotes NO production via H2O2 in mouse kidney arterial endothelial cells.
Yuan XH, Fan YY, Yang CR, Gao XR, Zhang LL, Hu Y, Wang YQ, Jun H
The Journal of steroid biochemistry and molecular biology 2016 Jan;155(Pt A):104-11
The Journal of steroid biochemistry and molecular biology 2016 Jan;155(Pt A):104-11
15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.
Snyder NW, Golin-Bisello F, Gao Y, Blair IA, Freeman BA, Wendell SG
Chemico-biological interactions 2015 Jun 5;234:144-53
Chemico-biological interactions 2015 Jun 5;234:144-53
Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver.
Ma Q, Zhao J, Cao W, Liu J, Cui S
American journal of physiology. Gastrointestinal and liver physiology 2015 Feb 15;308(4):G277-86
American journal of physiology. Gastrointestinal and liver physiology 2015 Feb 15;308(4):G277-86
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L
Longevity & healthspan 2014;3(1):10
Longevity & healthspan 2014;3(1):10
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
Gunjima K, Tomiyama R, Takakura K, Yamada T, Hashida K, Nakamura Y, Konishi T, Matsugo S, Hori O
Journal of cellular biochemistry 2014 Jan;115(1):151-60
Journal of cellular biochemistry 2014 Jan;115(1):151-60
Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner.
Ravuri C, Svineng G, Huseby NE
Free radical research 2013 May;47(5):394-403
Free radical research 2013 May;47(5):394-403
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77
Cell reports 2013 May 30;3(5):1663-77
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 14241-1-AP(GCLM antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using GCLM antibody 14241-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 14241-1-AP(GCLM antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 14241-1-AP(GCLM antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue