Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS2927 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GCSm ÎÛ (V91) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 50-100 of Human GCSm-ÎÛ.
- Description
- Gamma-glutamylcysteine synthetase (ÎÛ-GCS) is the rate limiting enzyme for glutathione (L-ÎÛ-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. ÎÛ-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines. The human ÎÛ-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human ÎÛ-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of ÎÛ-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of GCSm-¦Ã (V91) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate