BS2926

antibody from Bioworld Technology, Inc

Targeting: GCLC GCS, GLCL, GLCLC

Western blot (Data presented on provider website)

Antibody Data

Product number

BS2926

Provider

Bioworld Technology, Inc

Product name

GCSc ÎÛ (E315) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 300-350 of Human GCSc-ÎÛ.

Description

The GCLC gene consists of 16 exons and encodes the 636 amino acid protein ÎÛ-GCSc (ÎÛ-glutamylcysteine synthetase heavy subunit), also designated ÎÛ-Lglutamate- L-cysteine ligase catalytic subunit (GLCLC). ÎÛ-GCSc is expressed in hemocytes, brain, liver and kidney. ÎÛ-GCSc associates with a regulatory or modifier subunit, ÎÛ-GCSm (ÎÛ-glutamylcysteine synthetase light subunit), to form a heterodimer, ÎÛ-GCS. ÎÛ-GCS is the first enzyme involved and the rate determining step in glutathione iosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of ÎÛ-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of ÎÛ-GCS.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.