orb67138

antibody from Biorbyt

Targeting: DKK1 DKK-1, SK

Western blot (Data presented on provider website)

Antibody Data

Product number

orb67138

Provider

Biorbyt

Product name

DKK1 antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to DKK1.Dickkopf-related protein 1 (DKK1) belongs to the dickkopf family. DKK1 is a secreted protein thatinduces anterior development by antagonizing canonical Wnt signaling upstream of its effect on betacateninregulation. DKK1 inhibits LRP5/6 interaction with Wnt and by forming a ternary complex withthe transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play animportant role in vertebrate development, where they locally inhibit Wnt regulated processes such asantero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult,Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 ul

Storage

-20°C