BAF1096

antibody from Novus Biologicals

Targeting: DKK1 DKK-1, SK

Western blot (Data presented on provider website)

Antibody Data

Product number

BAF1096

Provider

Novus Biologicals

Product name

Goat Polyclonal Dkk-1 Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human Dkk-1 in ELISAs and Western blots. In sandwich immunoassays, approximately 85% cross-reactivity with rmDkk-1 is observed and less than 0.2% cross-reactivity with rhDkk-4 is observed.

Reactivity

Human

Host

Goat

Conjugate

Biotin

Isotype

IgG

Vial size

50 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells.

Jumpertz S, Hennes T, Asare Y, Schütz AK, Bernhagen J
Cellular signalling 2017 Jun;34:38-46

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Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis.

Gustafson B, Eliasson B, Smith U
Diabetologia 2010 Mar;53(3):536-40

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Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WE
Bone 2009 Oct;45(4):726-35

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Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.

Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, Braendle E, Stover D, Sezer O
European journal of haematology 2009 Jan;82(1):31-8

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Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD Jr
Blood 2008 Jul 1;112(1):196-207

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Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women.

Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M, Study of Osteoporotic Fractures Research Group.
Arthritis and rheumatism 2007 Oct;56(10):3319-25

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Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone.

Naot D, Bava U, Matthews B, Callon KE, Gamble GD, Black M, Song S, Pitto RP, Cundy T, Cornish J, Reid IR
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Feb;22(2):298-309

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Dickkopf-1 is a master regulator of joint remodeling.

Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G
Nature medicine 2007 Feb;13(2):156-63