RA0183

antibody from Oursmab

Targeting: DKK1 DKK-1, SK

Western blot (Supportive data in Antibodypedia)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0183

Provider

Oursmab

Product name

Sirexatamab (Biosimilar Reference Antibody) (DKK1)

Antibody type

Monoclonal

Description

Sirexatamab is a humanized IgG4 monoclonal antibody targeting Dickkopf-related protein 1 (DKK1), a secreted inhibitor of the Wnt/¦Â-catenin signaling pathway. By binding to and neutralizing DKK1, it restores Wnt pathway activity, promoting bone formation and potentially modulating tumor microenvironment signaling. It is being developed for the treatment of bone metastatic cancers (e.g., prostate, breast cancer) and osteolytic bone diseases.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Sirexatamab (Biosimilar Reference Antibody) (DKK1)-RA0183-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.