Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BAF1096 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Dkk-1 Biotinylated Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Dkk-1 in ELISAs and Western blots. In sandwich immunoassays, approximately 85% cross-reactivity with rmDkk-1 is observed and less than 0.2% cross-reactivity with rhDkk-4 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Biotin
- Antigen sequence
O94907- Isotype
- IgG
- Vial size
- 50 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells.
Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis.
Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.
Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.
Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.
Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women.
Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone.
Dickkopf-1 is a master regulator of joint remodeling.
Jumpertz S, Hennes T, Asare Y, Schütz AK, Bernhagen J
Cellular signalling 2017 Jun;34:38-46
Cellular signalling 2017 Jun;34:38-46
Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis.
Gustafson B, Eliasson B, Smith U
Diabetologia 2010 Mar;53(3):536-40
Diabetologia 2010 Mar;53(3):536-40
Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.
Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WE
Bone 2009 Oct;45(4):726-35
Bone 2009 Oct;45(4):726-35
Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.
Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, Braendle E, Stover D, Sezer O
European journal of haematology 2009 Jan;82(1):31-8
European journal of haematology 2009 Jan;82(1):31-8
Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.
Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD Jr
Blood 2008 Jul 1;112(1):196-207
Blood 2008 Jul 1;112(1):196-207
Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women.
Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M, Study of Osteoporotic Fractures Research Group.
Arthritis and rheumatism 2007 Oct;56(10):3319-25
Arthritis and rheumatism 2007 Oct;56(10):3319-25
Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone.
Naot D, Bava U, Matthews B, Callon KE, Gamble GD, Black M, Song S, Pitto RP, Cundy T, Cornish J, Reid IR
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Feb;22(2):298-309
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Feb;22(2):298-309
Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G
Nature medicine 2007 Feb;13(2):156-63
Nature medicine 2007 Feb;13(2):156-63
No comments: Submit comment
No validations: Submit validation data