12894-1-AP

antibody from Proteintech Group

Targeting: RPN1 OST1

Provider product page for 12894-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
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Validations
Western blot [1]

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Product number: 12894-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12894-1-AP, RRID:AB_2170474
Product name: RPN1 antibody
Antibody type: Polyclonal
Description: RPN1 antibody (Cat. #12894-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RPN1 protein structure - 12894-1-AP shown in red.

Submitted references Based on disulfide accumulation, leveraging a THBS1-signature to improve the outcome of head and neck carcinoma patients.

Jin Y, Wang Z, Zhou C, Wen M, Zhou Y, Huang S
International journal of biological macromolecules 2025 Sep 15;328(Pt 2):147679

CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1.

Chen W, Zhai Y, Yang X, Zhang W, Gao D, Zhao X, Zhao N, Zhang Y, Yuan Q, Zhao Z, Wu Q, Xie Y, Zhao J, Dong Z, Liu K, Jiang Y
Cell death discovery 2025 Nov 7;11(1):512

Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction.

Tatekoshi Y, Mahmoodzadeh A, Shapiro JS, Liu M, Bianco GM, Tatekoshi A, Camp SD, De Jesus A, Koleini N, De La Torre S, Wasserstrom JA, Dillmann WH, Thomson BR, Bedi KC, Margulies KB, Weinberg SE, Ardehali H
Cell metabolism 2025 Jul 1;37(7):1584-1600.e10

Integrative Disulfidptosis-Based Risk Assessment for Prognostic Stratification and Immune Profiling in Glioma.

Niu X, Li G, Kahlert UD, Ding L, Zheng J, Li C, Shi W, Huang L, Yu Z
Journal of cellular and molecular medicine 2025 Feb;29(4):e70429

Chemical Glycoproteomic Profiling in Rice Seedlings Reveals N-glycosylation in the ERAD-L Machinery.

Lei C, Li X, Li W, Chen Z, Liu S, Cheng B, Hu Y, Song Q, Qiu Y, Zhou Y, Meng X, Yu H, Zhou W, Chen X, Li J
Molecular & cellular proteomics : MCP 2025 Feb;24(2):100883

Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.

Wang S, Li W, Wen J, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
mBio 2025 Dec 10;16(12):e0293025

RPN1 Is Associated With Immunosuppression in Pan-Cancer and Affects the Malignant Phenotype of Tumor.

Lin S, Wu C, Liu Q, Luo F, Tan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70978

Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.

Qin L, Liang T, Zhang H, Gong X, Wei M, Song X, Hu Y, Zhu X, Hu W, Li J, Wang J
Frontiers in immunology 2024;15:1512445

Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.

Zhao L, Zhang J, Song Q, Dai C, Qin Y, Li A
Frontiers in cell and developmental biology 2024;12:1516898

RPN1: a pan-cancer biomarker and disulfidptosis regulator.

Wang X, Zhu HQ, Lin SM, Xia BY, Xu B
Translational cancer research 2024 May 31;13(5):2518-2534

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.

Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
bioRxiv : the preprint server for biology 2024 May 3;

Multi-Omics Insights into Disulfidptosis-Related Genes Reveal RPN1 as a Therapeutic Target for Liver Cancer.

He Y, Hu Y, Cheng Y, Li X, Chen C, Zhang S, He H, Cao F
Biomolecules 2024 Jun 10;14(6)

RPN1 promotes the proliferation and invasion of breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway.

Shen WJ, Zhang Y
Discover oncology 2024 Feb 1;15(1):25

Construction and experimental validation of a signature for predicting prognosis and immune infiltration analysis of glioma based on disulfidptosis-related lncRNAs.

Guo Y, Jiang Z, Chen Q, Xie D, Zhou Y, Yin W, Wang Z, Wang B, Ren C, Jiang X
Frontiers in immunology 2023;14:1291385

Manganese regulation of COPII condensation controls circulating lipid homeostasis.

Wang X, Huang R, Wang Y, Zhou W, Hu Y, Yao Y, Cheng K, Li X, Xu B, Zhang J, Xu Y, Zeng F, Zhu Y, Chen XW
Nature cell biology 2023 Nov;25(11):1650-1663

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.

Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B
Nature cell biology 2023 Mar;25(3):404-414

Signal recognition particle receptor-β (SR-β) coordinates cotranslational N-glycosylation.

Phoomak C, Rinis N, Baro M, Shrimal S, Bennett D, Shaffer SA, Lehrman M, Gilmore R, Contessa JN
Science advances 2023 Mar 17;9(11):eade8079

[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.

Tatekoshi Y, Shapiro JS, Liu M, Bianco GM, Tatekoshi A, De Jesus A, Koleini N, Wasserstrom JA, Dillmann WH, Weinberg SE, Ardehali H
Research square 2023 Jan 25;

Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.

Sicking M, Živná M, Bhadra P, Barešová V, Tirincsi A, Hadzibeganovic D, Hodaňová K, Vyleťal P, Sovová J, Jedličková I, Jung M, Bell T, Helms V, Bleyer AJ, Kmoch S, Cavalié A, Lang S
Life science alliance 2022 Apr;5(4)

The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress.

Phoomak C, Cui W, Hayman TJ, Yu SH, Zhao P, Wells L, Steet R, Contessa JN
Science advances 2021 Jan;7(3)

Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.

Zhang W, Huang B, Gao L, Huang C
International journal of molecular sciences 2021 Apr 21;22(9)

Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action.

Wang Y, Park D, Galermo AG, Gao D, Liu H, Lebrilla CB
Proteomics 2016 Dec;16(23):2977-2988

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN
Nature chemical biology 2016 Dec;12(12):1023-1030

Reconfiguration of the proteasome during chaperone-mediated assembly.

Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D
Nature 2013 May 23;497(7450):512-6

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RPN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RPN1. This antibody recognizes human, mouse, rat antigen. The RPN1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12894-1-AP.pdf

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