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- Antigen structure
- References [14]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55306-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55306-1-AP, RRID:AB_11182279
- Product name
- PDE2A antibody
- Antibody type
- Polyclonal
- Description
- PDE2A antibody (Cat. #55306-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Anacardic Acid Inhibits Pde2a to Enhance Colonic Epithelial Barrier Integrity in the Improvement of Diabetic Cardiomyopathy.
Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury.
Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure.
Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
Artesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.
Impaired Platelet Function and Thrombus Formation in PDE5A-Deficient Mice.
Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.
Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress.
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.
17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Ge R, Yin J, Meng H, Huang X, Sun L, Zheng Y, Yang J, Wu H
Molecular nutrition & food research 2026 Apr;70(8):e70464
Molecular nutrition & food research 2026 Apr;70(8):e70464
Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury.
Yang WJ, Han J, Cao ZX, Yang L, Wang JN, Sun T
ACS chemical neuroscience 2025 Jul 16;16(14):2629-2638
ACS chemical neuroscience 2025 Jul 16;16(14):2629-2638
Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure.
Kamel R, Bourcier A, Margaria JP, Jin V, Varin A, Hivonnait A, Mercier-Nomé F, Mika D, Ghigo A, Charpentier F, Algalarrondo V, Hirsch E, Fischmeister R, Vandecasteele G, Leroy J
Journal of the American Heart Association 2025 Feb 4;14(3):e037343
Journal of the American Heart Association 2025 Feb 4;14(3):e037343
Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
Chen SC, Chen YH, Song Y, Zong SH, Wu MX, Wang W, Wang H, Zhang F, Zhou YM, Yu HY, Zhang HT, Zhang FF
The international journal of neuropsychopharmacology 2024 Oct 1;27(10)
The international journal of neuropsychopharmacology 2024 Oct 1;27(10)
Artesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.
Wu Y, Shi B, He Y, Wang S, Zhou J, Qi J, Ding J, Wang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70225
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70225
Impaired Platelet Function and Thrombus Formation in PDE5A-Deficient Mice.
Gui X, Chu X, Du Y, Wang Y, Zhang S, Ding Y, Tong H, Xu M, Li Y, Ju W, Sun Z, Li Z, Zeng L, Xu K, Qiao J
Thrombosis and haemostasis 2023 Feb;123(2):207-218
Thrombosis and haemostasis 2023 Feb;123(2):207-218
Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.
Chen L, Zhou J, Zhao Z, Zhu Y, Xing J, An J, Guo X
Cells 2022 Dec 23;12(1)
Cells 2022 Dec 23;12(1)
Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress.
Zhu X, Li T, Hu E, Duan L, Zhang C, Wang Y, Tang T, Yang Z, Fan R
Frontiers in pharmacology 2021;12:791097
Frontiers in pharmacology 2021;12:791097
Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
Lobo MJ, Reverte-Salisa L, Chao YC, Koschinski A, Gesellchen F, Subramaniam G, Jiang H, Pace S, Larcom N, Paolocci E, Pfeifer A, Zanivan S, Zaccolo M
Communications biology 2020 Oct 21;3(1):596
Communications biology 2020 Oct 21;3(1):596
RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.
Eshraghi M, Ramírez-Jarquín UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S
Science advances 2020 May;6(18):eaaz7001
Science advances 2020 May;6(18):eaaz7001
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.
Pignatti E, Leng S, Yuchi Y, Borges KS, Guagliardo NA, Shah MS, Ruiz-Babot G, Kariyawasam D, Taketo MM, Miao J, Barrett PQ, Carlone DL, Breault DT
Cell reports 2020 Apr 21;31(3):107524
Cell reports 2020 Apr 21;31(3):107524
17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.
Pozdniakova S, Guitart-Mampel M, Garrabou G, Di Benedetto G, Ladilov Y, Regitz-Zagrosek V
British journal of pharmacology 2018 Oct;175(20):3876-3890
British journal of pharmacology 2018 Oct;175(20):3876-3890
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.
Liu K, Li D, Hao G, McCaffary D, Neely O, Woodward L, Ioannides D, Lu CJ, Brescia M, Zaccolo M, Tandri H, Ajijola OA, Ardell JL, Shivkumar K, Paterson DJ
JCI insight 2018 May 3;3(9)
JCI insight 2018 May 3;3(9)
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Módis K, Panopoulos P, Coletta C, Papapetropoulos A, Szabo C
Biochemical pharmacology 2013 Nov 1;86(9):1311-9
Biochemical pharmacology 2013 Nov 1;86(9):1311-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 55306-1-AP(PDE2A antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 55306-1-AP(PDE2A antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDE2A antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PDE2A. This antibody recognizes human,mouse,rat antigen. The PDE2A antibody has been validated for the following applications: ELISA, WB, IHC analysis.
