SSTR1

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Description

Somatostatin receptor 1

Tissue specificity

Tissue enhanced (brain, intestine, stomach)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

14 (38207904 - 38213067)

Ensembl ID

ENSG00000139874  (ver. 103.38)

Orthologs

Mouse Sstr1: ENSMUSG00000035431

UniProt

P30872

neXtProt

NX_P30872

Human splice variants
Mouse splice variants

Protein structure