ADD3

gene product
ADDL
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
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185 antibodies from 27 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
3 antibodies
Atlas Antibodies
1 antibody
antibodies-online
75 antibodies
Invitrogen Antibodies
3 antibodies
Bioworld Technology, Inc
1 antibody
Proteintech Group
1 antibody
NovoPro Bioscience Inc.
3 antibodies
OriGene
4 antibodies
Biorbyt
10 antibodies
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
30 antibodies
Aviva Systems Biology
4 antibodies
Bethyl Laboratories
2 antibodies
Boster Biological Technology
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
1 antibody
Affinity Biosciences
1 antibody
Abnova Corporation
3 antibodies
GeneTex
2 antibodies
United States Biological
25 antibodies
St John's Laboratory
1 antibody
MyBioSource
4 antibodies
Creative Diagnostics
3 antibodies
Abgent
1 antibody
EMD Millipore
1 antibody
ProSci
1 antibody
Sigma-Aldrich
1 antibody