10833-1-AP

antibody from Proteintech Group

Targeting: EPHX2 ABHD20

Provider product page for 10833-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 10833-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10833-1-AP, RRID:AB_2098246
Product name: EPHX2 antibody
Antibody type: Polyclonal
Description: KD/KO validated EPHX2 antibody (Cat. #10833-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EPHX2 protein structure - 10833-1-AP shown in red.

Submitted references Integrated bioinformatics to identify and validate the role of oxidative stress-related gene EPHX2 in laryngeal cancer.

Liu X, Qiao W, Zhao Y, Liu A, He J, Xie Z, XinBai, Tang J
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2026 Jan;283(1):303-316

CYP4X1/sEH-Dependent Endocannabinoid Metabolism Drives Fibroblast-Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer.

Mo M, Chen X, Liu Y, Wang C, Chen X, Zhang N, He N, Li Y, Wang J, Chen H, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e07695

Time-of-Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins.

Liu Y, Lu M, Du Y, Xu J, Fan M, Xue C, Liu Y
Exploration (Beijing, China) 2026 Feb;6(1):20240073

Alterations in mitochondria and cellular senescence in aged sEH null female kidneys.

Yousef A, Fang L, Heidari M, Huang A, Kondraciuk P, Yee KA, Mengel M, Seubert JM
GeroScience 2026 Apr;48(2):2707-2725

EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming.

Guan B, Huang C, He J, Shan W, Cui D, Li X, Liang C, Hao Z
Frontiers in oncology 2025;15:1541429

Epoxide hydrolases are involved in the metabolism of 5(6)-epoxyeicosatrienoic acid.

Zhou X, Liu YN, Yin HH, Liu JY
Biochemical and biophysical research communications 2025 Sep 8;778:152394

CYP2C18-EETs-mediated arachidonic acid metabolism results in ferroptosis in arsenic-induced hepatic insulin resistance.

Zhang J, Liu Z, Wang Q, Luo H, Li H, Ding X, Qiu T, Yao X, Bai J, Wang N, Yang G, Sun X
Ecotoxicology and environmental safety 2025 Oct 1;304:119064

Inhibiting Soluble Epoxide Hydrolase Suppresses NF-κB p65 Signaling and Reduces CXCL10 Expression as a Potential Therapeutic Target in Hashimoto's Thyroiditis.

Feng J, Xu X, Cai W, Yang X, Niu R, Han Z, Tian L
The Journal of clinical endocrinology and metabolism 2024 Sep 16;109(10):2579-2588

Gasdermin D-mediated metabolic crosstalk promotes tissue repair.

Chi Z, Chen S, Yang D, Cui W, Lu Y, Wang Z, Li M, Yu W, Zhang J, Jiang Y, Sun R, Yu Q, Hu T, Lu X, Deng Q, Yang Y, Zhao T, Chang M, Li Y, Zhang X, Shang M, Xiao Q, Ding K, Wang D
Nature 2024 Oct;634(8036):1168-1177

Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.

Wu H, Li D, Zhang CY, Huang LL, Zeng YJ, Chen TG, Yu K, Meng JW, Lin YX, Guo R, Zhou Y, Gao G
European journal of pharmacology 2024 Nov 15;983:176824

SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.

Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294

Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2.

Dang W, Li F, Gao R, Zhang C, Cheng H, Wu Z, Yang T, Pan J, Tang X, Gao Y
International journal of molecular sciences 2024 Dec 13;25(24)

Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex.

Qin Y, Liu Q, Wang S, Wang Q, Du Y, Yao J, Chen Y, Yang Q, Wu Y, Liu S, Zhao M, Wei G, Yang L
ACS pharmacology & translational science 2024 Apr 12;7(4):1002-1012

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.

Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC
International journal of biological sciences 2023;19(1):294-310

Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.

Su R, Cao W, Ma G, Li W, Li Z, Liu Y, Chen L, Chen Z, Li X, Cui P, Huang G
Frontiers in pharmacology 2023;14:1326245

The effect of acupuncture on lateral habenular nucleus and intestinal microflora in depression model rats.

Chen W, Chen Y, Aslam MS, Shen J, Tong T, Yan S, Cheng W, Huang Z, Li J, Liu S, Li J, Zeng J, Li M, You Z, Meng X
Behavioural brain research 2023 Oct 18;455:114627

L-theanine regulates the immune function of SD rats fed high-protein diets through the FABP5/IL-6/STAT3/PPARα pathway.

Zhang Y, Song Y, Zhang J, Li L, He L, Bo J, Gong Z, Xiao W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114095

Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.

Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456

Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids.

Zhao C, Jiang X, Peng L, Zhang Y, Li H, Zhang Q, Wang Y, Yang F, Wu J, Wen Z, He Z, Shen J, Chen C, Wang DW
Journal of molecular and cellular cardiology 2023 Dec;185:13-25

Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.

Zhou Y, Wang XC, Wei JH, Xue HM, Sun WT, He GW, Yang Q
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166643

EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation.

Zhou Y, Li X, Guan A, Zhou H, Zhu Y, Wang R, Li R
Frontiers in oncology 2022;12:870721

Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats.

Zhu X, Li K, Gao Y
Biochemical and biophysical research communications 2022 May 28;606:121-127

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification.

Lu S, Meng Z, Tan Y, Wu C, Huang Z, Huang J, Fu C, Stalin A, Guo S, Liu X, You L, Li X, Zhang J, Zhou W, Zhang X, Wang M, Wu J
BMC complementary medicine and therapies 2022 Mar 2;22(1):54

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma.

Zhan K, Bai Y, Liao S, Chen H, Kuang L, Luo Q, Lv L, Qiu L, Mei Z
Molecular medicine reports 2021 Sep;24(3)

Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.

Labitzke EM, Diani-Moore S, Rifkind AB
Archives of biochemistry and biophysics 2007 Dec 1;468(1):70-81

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10833-1-AP(EPHX2 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EPHX2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human EPHX2. This antibody recognizes human antigen. The EPHX2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10833-1-AP.pdf

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