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- Antibody Data
- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 24529-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- HPSE antibody
- Antibody type
- Polyclonal
- Description
- HPSE antibody (Cat. #24529-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.
Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS.
Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1/NF-κB/HPSE pathway.
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study.
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Artesunate inhibits macrophage-like phenotype switching of vascular smooth muscle cells and attenuates vascular inflammatory injury in atherosclerosis via NLRP3.
In Vitro and In Vivo Analyses Reveal Tumor-Derived Exosome miR-558 Promotes Angiogenesis in Tongue Squamous Cell Carcinoma by Targeting Heparinase.
Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1.
Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice.
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.
Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.
Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)
Nucleic acids research 2026 Feb 5;54(4)
Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS.
Chen Z, He Y, Zhang J, Ge Q, Du T, Fan Z, Zhou J, Yang X, Shen B, Wei Z
PloS one 2025;20(5):e0321730
PloS one 2025;20(5):e0321730
Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1/NF-κB/HPSE pathway.
Xu W, Ou D, Zhao Y, Liu Y, Yan P, Li S, Sun Q, Zhang X, Liu H, Huang J, Fang Y
Cellular signalling 2025 Oct;134:111909
Cellular signalling 2025 Oct;134:111909
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
Zhang K, Wu G, Chen Y, Hu Q, Li Y, Jiang X, Gu C, Zhang N, Zhao F
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study.
Packialakshmi B, Limerick E, Ackerman HC, Lin X, Nekhai S, Oliver JD 3rd, Stewart IJ, Knepper MA, Fitzhugh C, Zhou X
Frontiers in physiology 2024;15:1300667
Frontiers in physiology 2024;15:1300667
Weighted gene co-expression network analysis and single-cell sequence analysis uncover immune landscape and reveal hub genes of necroptosis in macrophages in myocardial ischaemia-reperfusion injury.
Ma X, Xie J, Li B, Shan H, Jia Z, Liu W, Dong Y, Han S, Jin Q
International immunopharmacology 2024 Oct 25;140:112761
International immunopharmacology 2024 Oct 25;140:112761
Artesunate inhibits macrophage-like phenotype switching of vascular smooth muscle cells and attenuates vascular inflammatory injury in atherosclerosis via NLRP3.
Liu P, Wang Y, Tian K, Bai X, Wang Y, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116255
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116255
In Vitro and In Vivo Analyses Reveal Tumor-Derived Exosome miR-558 Promotes Angiogenesis in Tongue Squamous Cell Carcinoma by Targeting Heparinase.
Ding B, Chen Q, Wu Z, Li X, Ding Y, Wu Q, Han L, Wu H
Technology in cancer research & treatment 2024 Jan-Dec;23:15330338241261615
Technology in cancer research & treatment 2024 Jan-Dec;23:15330338241261615
Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1.
Li X, Xu SJ, Jin B, Lu HS, Zhao SK, Ding XF, Xu LL, Li HJ, Liu SC, Chen J, Chen G
Oncology letters 2024 Feb;27(2):83
Oncology letters 2024 Feb;27(2):83
Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice.
O'Shea TM, Ao Y, Wang S, Ren Y, Cheng AL, Kawaguchi R, Shi Z, Swarup V, Sofroniew MV
Nature neuroscience 2024 Aug;27(8):1505-1521
Nature neuroscience 2024 Aug;27(8):1505-1521
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liang X, Yang Y, Huang C, Ye Z, Lai W, Luo J, Li X, Yi X, Fan JB, Wang Y, Wang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.
Yang C, Zhang S, Chang X, Huang Y, Cui D, Liu Z
Experimental and therapeutic medicine 2021 Jun;21(6):659
Experimental and therapeutic medicine 2021 Jun;21(6):659
Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.
Zhan YA, Qiu XL, Wang XZ, Zhao N, Qian KJ
Neural regeneration research 2021 Jul;16(7):1288-1293
Neural regeneration research 2021 Jul;16(7):1288-1293
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.
Li Y, Zheng F, Xiao X, Xie F, Tao D, Huang C, Liu D, Wang M, Wang L, Zeng F, Jiang G
EMBO reports 2017 Sep;18(9):1646-1659
EMBO reports 2017 Sep;18(9):1646-1659
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.
Xu G, Qin Q, Yang M, Qiao Z, Gu Y, Niu J
Diabetes research and clinical practice 2017 Feb;124:30-40
Diabetes research and clinical practice 2017 Feb;124:30-40
Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.
Wang X, Zuo D, Chen Y, Li W, Liu R, He Y, Ren L, Zhou L, Deng T, Wang X, Ying G, Ba Y
British journal of cancer 2014 Nov 11;111(10):1965-76
British journal of cancer 2014 Nov 11;111(10):1965-76
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 24529-1-AP( HPSE Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HPSE antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HPSE. This antibody recognizes human, mouse antigen. The HPSE antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
