BS7817

antibody from Bioworld Technology, Inc
Targeting: HPSE HPA, HPSE1, HSE1
Provider product page for BS7817
Western blot
Immunohistochemistry

Antibody data

Product number
BS7817 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HPSE polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HPSE.
Description
Heparanases (HPA) degrade heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and play animportant role in the extravasation of blood-borne tumor cells and inflammatory leukocytes. HPA1 dismantles the subendothelial basal membrane and facilitates the metastasis of blood-borne tumor cells. Furthermore, HPA1 induces angiogenesis and likely promotes the vascularization of tumors. Upon degradation, HPAs free growth factors and cytokines that stimulate cell proliferation and chemotaxis. Fibroblasts endocytose extracellular HPA1 for cytoplasmic accumulation in vitro. Proteolytic processing at the cell surface of a precursor begets an active form of HPA1.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HPSE protein structure - BS7817 shown in red.