19968-1-AP

antibody from Proteintech Group

Targeting: LHCGR HHG, LCGR, LGR2, LHR, ULG5

Provider product page for 19968-1-AP

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Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]

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Product number: 19968-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19968-1-AP, RRID:AB_10697685
Product name: LHCGR antibody
Antibody type: Polyclonal
Description: LHCGR antibody (Cat. #19968-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LHCGR protein structure - 19968-1-AP shown in red.

Submitted references Circadian rhythm disruption induces PCOS-like phenotypes by interfering with ovarian steroid hormone synthesis pathways.

Feng C, Guo L, Gao X, Ji X, Liu Y, Liu J, Liu S, Liu Y, Ma L, He X
The Journal of steroid biochemistry and molecular biology 2026 May;259:106980

Human chorionic gonadotropin inhibits locomotion but not food intake independently of the area postrema and the nucleus tractus solitarius in female mice.

Anan M, Kagawa K, Okamatsu-Ogura Y, Yamaguchi S, Yano-Nashimoto S
Physiology & behavior 2026 Jan 1;303:115151

Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.

Tang Z, Zheng Y
Cells 2025 Sep 4;14(17)

Optimizing in vitro maturation outcomes of oocytes following gonadotropin priming in premenarcheal girls undergoing ovarian tissue cryopreservation.

Zhao W, Guo Y, Zhou C, Sun P, Li T, Zeng H, Li J, Fang C, Liang X
Fertility and sterility 2025 Nov 15;124(5 Pt 2):1082-1092

Characteristics of polycystic ovary syndrome rat models induced by letrozole, testosterone propionate and high-fat diets.

Hu R, Huang Y, Liu Z, Dong H, Ma W, Song K, Xu X, Wu X, Geng Y, Li F, Zhang M, Song Y
Reproductive biomedicine online 2025 Jan;50(1):104296

Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.

Li Y, Li F, Shu J, Meng C, Zhang J, Zhang J, Qian Y, Wang H, Ding Q, Cao S
Animal reproduction science 2025 Jan;272:107649

Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.

Shi L, Ying H, Dai Y, Rong Y, Chen J, Zhou F, Wang S, Xu S, Tong X, Zhang S
Human reproduction (Oxford, England) 2025 Jan 1;40(1):119-137

PTX3 impairs granulosa cell function by promoting the secretion of inflammatory cytokines in M1 macrophages via the JAK pathway.

Chen Y, Luo X, Li Y, Liu L, Liu Z, Tan Y, Chen Y
Steroids 2025 Feb;214:109541

GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.

Mou L, Sun D, Qu J, Tan X, Wang S, Zeng Q, Liu C
Journal of hazardous materials 2024 Sep 5;476:135101

Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.

Jamal MA, Cheng Y, Jiao D, Cheng W, Zou D, Wang X, Wei T, Guo J, Xu K, Zhao H, Pu S, Yang C, Qing Y, Jia B, Li H, Zhao R, Zhao HY, Wei HJ
Biological research 2024 Sep 4;57(1):60

Integrated single-cell and spatial transcriptomics reveal microenvironment disruptions by androgen in mouse ovary.

Luo M, Yang X, Zhou M, Zhang J, Yu B, Lian H, Ye J
iScience 2024 Oct 18;27(10):111028

Chronic exposure to polystyrene microplastics induced LHR reduction and decreased testosterone levels through NF-κB pathway.

Jin H, Ding J, Liu H, Yang L, Li D, Han X
Environmental pollution (Barking, Essex : 1987) 2024 Oct 1;358:124543

Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and are reproductive status dependent.

Mey M, Bhatta S, Suresh S, Labrador LM, Piontkivska H, Casadesus G
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167165

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats.

Yang G, Li S, Cai S, Zhou J, Ye Q, Zhang S, Chen F, Wang F, Zeng X
Food & function 2024 Jan 22;15(2):704-715

Phoenixin-14 as a novel direct regulator of porcine luteal cell functions†.

Mlyczyńska E, Kurowska P, Wachowska D, Grzesiak M, Dupont J, Rak A
Biology of reproduction 2024 Jan 13;110(1):154-168

miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.

Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17

Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication.

Hu R, Huang Y, Geng Y, Liu Z, Li F, Zhang Z, Ma W, Song K, Dong H, Song Y, Zhang M
Journal of ethnopharmacology 2024 Apr 6;323:117654

Enhancing endometrial receptivity: the roles of human chorionic gonadotropin in autophagy and apoptosis regulation in endometrial stromal cells.

Wang B, Gao M, Yao Y, Shen H, Li H, Sun J, Wang L, Zhang X
Reproductive biology and endocrinology : RB&E 2024 Apr 4;22(1):37

Effects of chronic dichlorodiphenyldichloroethylene exposure on testosterone secretion and steroidogenic pathway in the male gonad.

Molina EM, Kavazis AN, Mendonça MT, Akingbemi BT
Biology of reproduction 2023 Jul 11;109(1):65-72

Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats.

Wang H, Feng X, Wang T, Pan J, Zheng Z, Su Y, Weng H, Zhang L, Chen L, Zhou L, Zheng L
General and comparative endocrinology 2023 Jan 1;330:114138

miR-143-3p Promotes Ovarian Granulosa Cell Senescence and Inhibits Estradiol Synthesis by Targeting UBE2E3 and LHCGR.

Deng J, Tang Y, Li L, Huang R, Wang Z, Ye T, Xiao Z, Hu M, Wei S, Wang Y, Yang Y, Huang Y
International journal of molecular sciences 2023 Aug 8;24(16)

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.

Geng T, Sun Y, Cheng L, Cao Y, Zhang M, Hong Z, Ma L, Zhang Y
Frontiers in endocrinology 2022;13:853563

Acute hypoxia induced dysregulation of clock-controlled ovary functions.

Ding M, Lu Y, Huang X, Xing C, Hou S, Wang D, Zhang Y, Wang W, Zhang C, Zhang M, Meng F, Liu K, Liu G, Zhao J, Song L
Frontiers in physiology 2022;13:1024038

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.

Zheng S, Ma M, Chen Y, Li M
Basic & clinical pharmacology & toxicology 2022 Feb;130(2):240-253

Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.

Jin H, Yan M, Pan C, Liu Z, Sha X, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Particle and fibre toxicology 2022 Feb 17;19(1):13

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα.

Wang YM, Wu Y, Zheng YF, Wang HY
Cell death & disease 2021 Oct 25;12(11):999

Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells.

Su Y, Tian Z, Qi X, Luo D, Liu L, Liu S, Zheng D, Wei F, He Z, Guan Q
Nutrition & metabolism 2021 May 26;18(1):53

Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.

Wan YT, Liu S, Zhao SK, Luo YY, Lv YS, Qu DN, Liu MH, Li Y
Journal of assisted reproduction and genetics 2021 Apr;38(4):809-824

La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431

Evaluation of carvacrol on pituitary and sexual hormones and their receptors in the testicle of male diabetic rats.

Shoorei H, Khaki A, Shokoohi M, Khaki AA, Alihemmati A, Moghimian M, Abtahi-Eivary SH
Human & experimental toxicology 2020 Aug;39(8):1019-1030

β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway.

Wu W, Gao H, Li X, Peng S, Yu J, Liu N, Zhan G, Zhu Y, Wang K, Guo X
Cell cycle (Georgetown, Tex.) 2019 Jan;18(1):46-59

Placental biology of Down syndrome in relation to increased gene dosage.

Wong OGW, Ngan HYS, Cheung ANY
Hong Kong medical journal = Xianggang yi xue za zhi 2019 Aug;25 Suppl 5(4):33-35

Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization.

Wong OGW, Cheung CLY, Ip PPC, Ngan HYS, Cheung ANY
The American journal of pathology 2018 Oct;188(10):2307-2317

Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring.

Wang X, Sheng N, Cui R, Zhang H, Wang J, Dai J
Chemosphere 2017 Apr;172:260-267

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

Liu Y, Su X, Hao J, Chen M, Liu W, Liao X, Li G
International journal of molecular sciences 2016 Jan 13;17(1)

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

Ball CB, Rodriguez KF, Stumpo DJ, Ribeiro-Neto F, Korach KS, Blackshear PJ, Birnbaumer L, Ramos SB
PloS one 2014;9(5):e97324

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.

Nozawa K, Nagaoka K, Zhang H, Usuda K, Okazaki S, Taya K, Yoshida M, Watanabe G
Reproductive toxicology (Elmsford, N.Y.) 2014 Jul;46:77-84

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The LHCGR antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LHCGR. This antibody recognizes human,mouse,rat antigen. The LHCGR antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19968-1-AP.pdf

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