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- Antigen structure
- References [23]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 21632-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21632-1-AP, RRID:AB_11182931
- Product name
- KIF5B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KIF5B antibody (Cat. #21632-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis.
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA(A) receptor transport in a murine model.
Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules.
Mast cell granule motility and exocytosis is driven by dynamic microtubule formation and kinesin-1 motor function.
Decreased mitochondrial function in UVA-irradiated dermal fibroblasts causes the insufficient formation of type I collagen and fibrillin-1 fibers.
GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.
Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.
Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
Transport of c-MYC by Kinesin-1 for proteasomal degradation in the cytoplasm.
Cuevas EP, Martinez-Gonzalez L, Gordillo C, Tosat-Bitrián C, Pérez de la Lastra C, Sáenz A, Gil C, Palomo V, Martin-Requero Á, Martinez A
Neurobiology of disease 2024 Mar;192:106430
Neurobiology of disease 2024 Mar;192:106430
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
Liu G, He M, Wu C, Lv P, Sun H, Wang H, Xin X, Liao H
Experimental neurology 2024 Feb;372:114618
Experimental neurology 2024 Feb;372:114618
Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
Zheng R, Xu FX, Zhou L, Xu J, Shen Y, Hao K, Wang XT, Deng J
The Journal of physiology 2023 Sep;601(17):3905-3920
The Journal of physiology 2023 Sep;601(17):3905-3920
LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.
Wu G, Su J, Zeng L, Deng S, Huang X, Ye Y, Li R, Bai R, Zhuang L, Li M, Zhou Q, Zheng Y, Deng J, Zhang S, Chen R, Lin D, Zhang J, Zheng J
Cell death and differentiation 2023 Oct;30(10):2213-2230
Cell death and differentiation 2023 Oct;30(10):2213-2230
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Zhu Z, Li X, Wang X, Zuo X, Ma Y, Gao X, Liang Z, Zhang Z, Song Z, Ding T, Ju C, Li P, Li K, Zhang J, Quan H, Wang Z, Hu X
Bioengineering & translational medicine 2023 May;8(3):e10473
Bioengineering & translational medicine 2023 May;8(3):e10473
Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA(A) receptor transport in a murine model.
Liu J, Ke P, Guo H, Gu J, Liu Y, Tian X, Wang X, Xiao F
Experimental & molecular medicine 2023 Jun;55(6):1159-1173
Experimental & molecular medicine 2023 Jun;55(6):1159-1173
Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules.
Lou JX, Liu YY, Bai JS, Cheng Y, Zhang J, Liu CC, Zhou B
Journal of virology 2023 Jan 31;97(1):e0192922
Journal of virology 2023 Jan 31;97(1):e0192922
Mast cell granule motility and exocytosis is driven by dynamic microtubule formation and kinesin-1 motor function.
Ibanga J, Zhang EL, Eitzen G, Guo Y
PloS one 2022;17(3):e0265122
PloS one 2022;17(3):e0265122
Decreased mitochondrial function in UVA-irradiated dermal fibroblasts causes the insufficient formation of type I collagen and fibrillin-1 fibers.
Katsuyama Y, Yamawaki Y, Sato Y, Muraoka S, Yoshida M, Okano Y, Masaki H
Journal of dermatological science 2022 Oct;108(1):22-29
Journal of dermatological science 2022 Oct;108(1):22-29
GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.
Bellio C, Emperador M, Castellano P, Gris-Oliver A, Canals F, Sánchez-Pla A, Zamora E, Arribas J, Saura C, Serra V, Tabernero J, Littlefield BA, Villanueva J
Cancers 2022 May 23;14(10)
Cancers 2022 May 23;14(10)
Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.
Wells KM, He K, Pandey A, Cabello A, Zhang D, Yang J, Gomez G, Liu Y, Chang H, Li X, Zhang H, Feng X, da Costa LF, Metz R, Johnson CD, Martin CL, Skrobarczyk J, Berghman LR, Patrick KL, Leibowitz J, Ficht A, Sze SH, Song J, Qian X, Qin QM, Ficht TA, de Figueiredo P
eLife 2022 May 19;11
eLife 2022 May 19;11
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
Chen XQ, Das U, Park G, Mobley WC
Alzheimer's research & therapy 2021 Mar 10;13(1):59
Alzheimer's research & therapy 2021 Mar 10;13(1):59
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Wang F, Chen X, Cheng H, Song L, Liu J, Caplan S, Zhu L, Wu JY
EMBO reports 2021 Jul 5;22(7):e52006
EMBO reports 2021 Jul 5;22(7):e52006
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Hou W, Kang W, Li Y, Shan Y, Wang S, Liu F
Virulence 2021 Dec;12(1):615-629
Virulence 2021 Dec;12(1):615-629
Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.
Zhou F, Xiong X, Li S, Liang J, Zhang X, Tian M, Li X, Gao M, Tang L, Li Y
Aging 2020 Jun 24;12(12):12142-12159
Aging 2020 Jun 24;12(12):12142-12159
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Olczak M, Poniatowski Ł, Kwiatkowska M, Samojłowicz D, Tarka S, Wierzba-Bobrowicz T
Folia neuropathologica 2019;57(1):51-62
Folia neuropathologica 2019;57(1):51-62
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Wang Q, Tian J, Chen H, Du H, Guo L
Neurobiology of disease 2019 Jul;127:410-418
Neurobiology of disease 2019 Jul;127:410-418
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Franchini DM, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, Scarlata CM, Lebras M, Rossi C, Ligat L, Pont F, Arimondo PB, Laurent C, Ayyoub M, Despas F, Lapeyre-Mestre M, Millevoi S, Fournié JJ
Cell reports 2019 Jan 2;26(1):94-107.e7
Cell reports 2019 Jan 2;26(1):94-107.e7
Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.
Adam F, Kauskot A, Kurowska M, Goudin N, Munoz I, Bordet JC, Huang JD, Bryckaert M, Fischer A, Borgel D, de Saint Basile G, Christophe OD, Ménasché G
Arteriosclerosis, thrombosis, and vascular biology 2018 May;38(5):1037-1051
Arteriosclerosis, thrombosis, and vascular biology 2018 May;38(5):1037-1051
Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.
Pesaresi M, Giatti S, Spezzano R, Romano S, Diviccaro S, Borsello T, Mitro N, Caruso D, Garcia-Segura LM, Melcangi RC
Biology of sex differences 2018 Jan 19;9(1):6
Biology of sex differences 2018 Jan 19;9(1):6
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera-Salcedo IK, Huang JD, Fischer A, González-Espinosa C, de Saint Basile G, Blank U, Ménasché G
The Journal of cell biology 2016 Oct 24;215(2):203-216
The Journal of cell biology 2016 Oct 24;215(2):203-216
Transport of c-MYC by Kinesin-1 for proteasomal degradation in the cytoplasm.
Lee CM
Biochimica et biophysica acta 2014 Sep;1843(9):2027-36
Biochimica et biophysica acta 2014 Sep;1843(9):2027-36
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KIF5B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human KIF5B. This antibody recognizes human,mouse,rat antigen. The KIF5B antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21632-1-AP(KIF5B antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21632-1-AP(KIF5B antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
