14552-1-AP

antibody from Proteintech Group

Targeting: MMP14 MT1-MMP

Provider product page for 14552-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [43]
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Validations
Western blot [1]

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Product number: 14552-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14552-1-AP, RRID:AB_2250751
Product name: MT1-MMP antibody
Antibody type: Polyclonal
Description: MT1-MMP antibody (Cat. #14552-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MMP14 protein structure - 14552-1-AP shown in red.

Submitted references CD48 is a novel immune checkpoint on tumour-associated macrophages in hepatocellular carcinoma.

Shi G, Xiao Y, Li Z, Qiu Y, Zhou Y, Zhang J, Li W, He L, Xie F, Cao H, Yu D, Du H, Li G, Zhang W, Wang S, Lei X, Zhang K, Zhang Y, Gao Y, Wang Z, Li M
Gut 2026 Jan 2;

The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.

Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L, Li F, Chen M, Chen Q, Wei W, Li H, Shen Y
Cellular & molecular biology letters 2026 Feb 11;31(1):22

ST7 binds YBX1 to suppress MMP14 expression and inhibit metastasis in non-small cell lung cancer.

Qin Y, Chen Y, Cao Q, Zhang B, Wan Y
Cellular signalling 2026 Aug;144:112554

TMED9: a potential therapeutic target and prognostic marker in glioma and its implications across pan-cancer contexts.

Mi B, Li C
Frontiers in immunology 2025;16:1558881

Matrix metalloproteinases are hallmark early biomarkers and therapeutic targets in FSHD.

Jung U, Wei E, Ahsan H, Mitanoska A, Chen K, Kyba M, Bosnakovski D
JCI insight 2025 Nov 10;10(21)

Ethyl caffeate alleviates inflammatory response and promotes recovery in septic-acute lung injury via the TNF-α/NF-κB/MMP9 Axis.

Huang Y, Li G, Li D, Liu C, Chen M, Cai L, Sun M, Xu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156700

Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.

Huang Z, Jiang Q, Zhang Q, Lu N, Rui X, Chen R, Wang Y, Wang Y, Xu X, Huang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501149

Dentin tubules as a long-term sustained release carrier to accelerate bone repair by loading FTY720.

Xie J, Huang H, Xu S, Zhou K, Chen X, Fang J, Zhao F
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:446-457

Network pharmacology and in vitro experiments reveal the potential therapeutic effects of Scrophularia ningpoensis Hemsl in the treatment of ameloblastoma.

Yi JR, Zeng B, Liu B, Li RF, Che YF, Man QW
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6):102146

Distinct immunophenotypic profiles and neutrophil heterogeneity in colorectal cancer.

Bai M, Jin Y, Jin Z, Xie Y, Chen J, Zhong Q, Wang Z, Zhang Q, Cai Y, Qun F, Yuki N, Xin C, Shen X, Zhu J
Cancer letters 2025 Apr 28;616:217570

Basement membrane-related MMP14 predicts poor prognosis and response to immunotherapy in bladder cancer.

Zhang X, Hong B, Li H, Zhao J, Li M, Wei D, Wang Y, Zhang N
BMC cancer 2024 Jun 19;24(1):746

FOLR1-stabilized β-catenin promotes laryngeal carcinoma progression through EGFR/AKT/GSK-3β pathway.

Tuo H, Li X, Du H, Li M, Xu C, Yu Z, Zhao H
Molecular carcinogenesis 2024 Jan;63(1):34-44

The association between activation of the ERK1/2-NF-κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model.

Chen T, Wu S, Feng L, Long S, Liu Y, Zhang C, Lu W, Shen Y, Jiang S, Chen W, Hong G, Zhou L, Wang F, Luo Y, Zou H
Transplant immunology 2024 Feb;82:101984

SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury.

Wang C, Xu Y, Xu M, Sun C, Zhang X, Tao X, Song T
Journal of neuroinflammation 2024 Feb 22;21(1):57

KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.

Yuan Q, Wu Y, Xue C, Zhao D, Wang H, Shen Y
Biochemical and biophysical research communications 2024 Aug 30;722:150156

Calreticulin regulates the expression of MMP14 and ADAR1 through EIF2AK2 signaling to promote the proliferation and progression of malignant melanoma cells.

Liang L, Wang J, Guo T, Huang L, Wu Y, Xu R, Huang T, Ma B
Neoplasma 2024 Apr;71(2):180-192

Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway.

Li B, Chen J, Wu Y, Luo H, Ke Y
International journal of biological sciences 2022;18(13):5123-5135

Heat Shock Proteins 70 Regulate Cell Motility and Invadopodia-Associated Proteins Expression in Oral Squamous Cell Carcinoma.

Ding LX, Zhang J, Yang SS, Wu J, Su T, Wang WM
Frontiers in endocrinology 2022;13:890218

ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14.

Guo D, Zhang X, Cui H, Yu D, Zhang H, Shi X, Pang C, Li J, Guo W, Zhang S
Frontiers in oncology 2022;12:821484

PLOD2 Is a Prognostic Marker in Glioblastoma That Modulates the Immune Microenvironment and Tumor Progression.

Kreße N, Schröder H, Stein KP, Wilkens L, Mawrin C, Sandalcioglu IE, Dumitru CA
International journal of molecular sciences 2022 May 27;23(11)

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Ferrand N, Fert A, Morichon R, Radosevic-Robin N, Zaoui M, Sabbah M
Cancers 2022 Mar 14;14(6)

miR-520d-3p/MIG-7 axis regulates vasculogenic mimicry formation and metastasis in osteosarcoma.

Yao N, Zhou J, Song J, Jiang Y, Zhang J
Neoplasma 2022 Jul;69(4):764-775

LOXL1-AS1 communicating with TIAR modulates vasculogenic mimicry in glioma via regulation of the miR-374b-5p/MMP14 axis.

Yi B, Li H, Cai H, Lou X, Yu M, Li Z
Journal of cellular and molecular medicine 2022 Jan;26(2):475-490

Dual VEGF/PDGF knockdown suppresses vasculogenic mimicry formation in choroidal melanoma cells via the Wnt5a/β-catenin/AKT signaling pathway.

Yuan Y, Geng B, Xu X, Zhao H, Bai J, Dou Z, Jia S, Yu X, Luo W
Acta histochemica 2022 Jan;124(1):151842

METTL3-mediated m(6)A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy.

Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, Huang Y, Zhu W, Wang J, Wen J, Meng X, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1721-1740

Urinary peptidomics reveals proteases involved in idiopathic membranous nephropathy.

Lin B, Liu J, Zhang Y, Wu Y, Chen S, Bai Y, Liu Q, Qin X
BMC genomics 2021 Nov 24;22(1):852

LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.

Ogoyama M, Ohkuchi A, Takahashi H, Zhao D, Matsubara S, Takizawa T
International journal of molecular sciences 2021 Jan 27;22(3)

GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.

Liu Y, Wang D, Lei M, Gao J, Cui Y, Jin X, Yu Q, Jiang Y, Guo Y, Liu Y, Cai L, Chen X
Aging 2021 Feb 11;13(4):5858-5874

SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.

Ren F, Wang D, Wang Y, Chen P, Guo C
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jul;27(7):1391-1399

Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.

Balabiyev A, Podolnikova NP, Mursalimov A, Lowry D, Newbern JM, Roberson RW, Ugarova TP
Molecular biology of the cell 2020 Aug 15;31(18):2002-2020

Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway.

Liu G, Ren F, Song Y
PeerJ 2019;7:e7163

VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.

Xu X, Zong Y, Gao Y, Sun X, Zhao H, Luo W, Jia S
BioMed research international 2019;2019:3909102

SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.

Ren F, Wang D, Wang Y, Chen P, Guo C
Reproductive sciences (Thousand Oaks, Calif.) 2019 Mar 4;:1933719119834341

NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.

Choi SY, Oh SY, Kang SH, Kang SM, Kim J, Lee HJ, Kwon TG, Kim JW, Hong SH
Cancers 2019 Mar 19;11(3)

Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis.

Wang D, Zheng J, Liu X, Xue Y, Liu L, Ma J, He Q, Li Z, Cai H, Liu Y
Molecular therapy. Nucleic acids 2019 Mar 1;14:465-482

MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells.

Fu X, Halim A, Tian B, Luo Q, Song G
Journal of cellular physiology 2019 Aug;234(8):14133-14144

Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.

Wang Y, Wang Y, Liu Z, Dong W, Yang B, Xia X, Song E, Song Y
Chemical research in toxicology 2018 Sep 17;31(9):954-963

MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells.

Duan Y, Dong Y, Dang R, Hu Z, Yang Y, Hu Y, Cheng J
Cell biology international 2018 Nov;42(11):1564-1574

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

Zhang XH, Zhang HY, Lu S, Jiang LL, Wu J, Yang YL, Zhang SA
European review for medical and pharmacological sciences 2018 Mar;22(5):1209-1215

Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.

Guo J, Cai H, Liu X, Zheng J, Liu Y, Gong W, Chen J, Xi Z, Xue Y
Molecular therapy. Nucleic acids 2018 Mar 2;10:170-186

Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.

Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P
International journal of molecular sciences 2018 Feb 15;19(2)

Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis.

Li Y, Wu Z, Yuan J, Sun L, Lin L, Huang N, Bin J, Liao Y, Liao W
Cancer letters 2017 Jun 1;395:31-44

Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.

Chen B, He T, Xing Y, Cao T
Experimental and therapeutic medicine 2017 Dec;14(6):6022-6026

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MMP14 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MMP14. This antibody recognizes human, mouse, rat, zebrafish antigen. The MMP14 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14552-1-AP.pdf

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