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- Antibody Data
- Antigen structure
- References [4]
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- Flow cytometry [1]
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- Product number
- MAB9181-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human MMP-14/MT1-MMP Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human MMP-14/MT1-MMP in direct ELISAs and Western blots. Does not detect E. coli-expressed recombinant human MMP-14 catalytic domain (aa 112-284).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P50281- Isotype
- IgG
- Antibody clone number
- 128527
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer.
Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion.
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.
Morgan RL, Behbahani-Nejad N, Endres J, Amin MA, Lepore NJ, Du Y, Urquhart A, Chung KC, Fox DA
PloS one 2016;11(9):e0162008
PloS one 2016;11(9):e0162008
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer.
Kaimal R, Aljumaily R, Tressel SL, Pradhan RV, Covic L, Kuliopulos A, Zarwan C, Kim YB, Sharifi S, Agarwal A
Cancer research 2013 Apr 15;73(8):2457-2467
Cancer research 2013 Apr 15;73(8):2457-2467
Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion.
Mierke CT, Bretz N, Altevogt P
The Journal of biological chemistry 2011 Oct 7;286(40):34858-71
The Journal of biological chemistry 2011 Oct 7;286(40):34858-71
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.
Mierke CT, Frey B, Fellner M, Herrmann M, Fabry B
Journal of cell science 2011 Feb 1;124(Pt 3):369-83
Journal of cell science 2011 Feb 1;124(Pt 3):369-83
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of MMP-14/MT1-MMP in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP Monoclonal Antibody (Catalog # MAB9181, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).
