21002-1-AP

antibody from Proteintech Group

Targeting: OTUD5 DKFZp761A052, DUBA

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

21002-1-AP

Provider

Proteintech Group

Product name

OTUD5 antibody

Antibody type

Polyclonal

Description

OTUD5 antibody (Cat. #21002-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Proteasome activity maintains cell-type-specific gene expression.

Lu X, Osei-Amponsa V, Michelis G, Castelino RE, Negi H, Das S, Turner JL, King JC, Martin D, Wang Y, Andresson T, Chari R, Werner A, Walters KJ
Cell reports 2026 Feb 24;45(2):116973

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Saquinavir induces pyroptosis through the OTUD5-JAK1-GSDME axis in hepatocellular carcinoma.

Yao L, Yao Y, He W, Xue Z, Zheng K, Lei Q, Deng Y, Liu Q, Shao Z, Liao Y
Free radical biology & medicine 2026 Apr;247:361-377

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OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38/JNK pathway.

Gu X, Zhu T, Hang G, Chen W, Chen H
Tissue & cell 2025 Oct;96:103008

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p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer.

Zhang J, Tian T, Li X, Xu K, Lu Y, Li X, Zhao X, Cui Z, Wang Z, Zhou Y, Xu Y, Li H, Zhang Y, Du Y, Lv L, Xu Y
Clinical and translational medicine 2025 Mar;15(3):e70271

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OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.

Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao C, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700

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OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1(S824).

Lam SY, van der Lugt R, Cerutti A, Yalçin Z, Thouin AM, Simonetta M, Jacobs JJL
Nature communications 2024 Oct 17;15(1):8960

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Dapagliflozin suppressed gastric cancer growth via regulating OTUD5 mediated YAP1 deubiquitination.

Ren K, Wang X, Ma R, Chen H, Min T, Ma Y, Xie X, Wang W, Deng X, Zhou Z, Li K, Zhu K, Hao N, Dang C, Sun T, Zhang H
European journal of pharmacology 2024 Nov 15;983:177002

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Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.

Zhao Y, Fan S, Zhu H, Zhao Q, Fang Z, Xu D, Lin W, Lin L, Hu X, Wu G, Min J, Liang G
Nature communications 2024 Jun 27;15(1):5441

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USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.

Tang Y, Wang T, Gu L, Xu Y, Yang Z, Zhu W, Zhang Q, Luo J, Cao J, Jiao Y
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1261-1274

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CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5.

Bai M, Lu K, Che Y, Fu L
Carcinogenesis 2024 Aug 12;45(8):595-606

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Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Meng Y, Zhang J, Long Y, Su J, Chen G, Li Y, Hu G, Liao X, Chen Q, Zhu Y
eLife 2022 Aug 1;11